Browsing by Keyword "G-Protein Signaling"
Now showing items 1-4 of 4
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Endothelial Differentiation Gene-1, a New Downstream Gene Is Involved in RTEF-1 Induced Angiogenesis in Endothelial Cells
(Public Library of Science, 2014)Related Transcriptional Enhancer Factor-1 (RTEF-1) has been suggested to induce angiogenesis through regulating target genes. Whether RTEF-1 has a direct role in angiogenesis and what specific genes are involved in RTEF-1 ... -
Gq/11-Mediated Signaling and Hypertrophy in Mice with Cardiac-Specific Transgenic Expression of Regulator of G-Protein Signaling 2
(Public Library of Science, 2012)Cardiac hypertrophy is a well-established risk factor for cardiovascular morbidity and mortality. Activation of \(G_{q/11}\)-mediated signaling is required for pressure overload-induced cardiomyocyte (CM) hypertrophy to ... -
\(Leu128^{3.43}\) (L128) and \(Val247^{6.40}\) (V247) of CXCR1 Are Critical Amino Acid Residues for G Protein Coupling and Receptor Activation
(Public Library of Science, 2012)CXCR1, a classic GPCR that binds IL-8, plays a key role in neutrophil activation and migration by activating phospholipase C (PLC)β through \(G\alpha_{15}\) and \(G\alpha_i\) which generates diacylglycerol and inositol ... -
The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist
(Public Library of Science, 2013)Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting ...