Browsing by FAS Department "Other Research Unit"

Now showing items 1-20 of 421

    • Acceptance of Mobile Technology by Older Adults: A Preliminary Study 

      Kim, Sunyoung; Gajos, Krzysztof Z; Muller, Michael; Grosz, Barbara J. (2016)
      Mobile technologies offer the potential for enhanced healthcare, especially by supporting self-management of chronic care. For these technologies to impact chronic care, they need to work for older adults, because the ...

    • Accurate Path Integration in Continuous Attractor Network Models of Grid Cells 

      Burak, Yoram; Fiete, Ila R. (Public Library of Science, 2009)
      Grid cells in the rat entorhinal cortex display strikingly regular firing responses to the animal's position in 2-D space and have been hypothesized to form the neural substrate for dead-reckoning. However, errors ...

    • Activation of the Immune Response is a Key Feature of Aging in Mice 

      Brink, Thore C.; Regenbrecht, Christian; Demetrius, Lloyd A.; Lehrach, Hans; Adjaye, James (Springer Netherlands, 2009)
      The process of aging is complex involving numerous factors centered on transcriptional changes with advanced age. This study was aimed at elucidating mechanisms involved in mouse aging by conducting both gene expression ...

    • Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations 

      Fulco, Charles P.; Nasser, Joseph; Jones, Thouis; Munson, Glen; Bergman, Drew T.; Subramanian, Vidya; Grossman, Sharon; Anyoha, Rockwell; Doughty, Benjamin; Patwardhan, Tejal A.; Nguyen, Tung H.; Kane, Michael; Perez, Elizabeth; Durand, Neva C.; Lareau, Caleb; Stamenova, Elena K.; Aiden, Erez Lieberman; Lander, Eric; Engreitz, Jesse (Cold Spring Harbor Laboratory, 2019-01-26)
      Mammalian genomes harbor millions of noncoding elements called enhancers that quantitatively regulate gene expression, but it remains unclear which enhancers regulate which genes. Here we describe an experimental approach, ...

    • Adaptation of CRISPR nucleases for eukaryotic applications 

      Ran, Fei Ann (Elsevier BV, 2016)
      Glucan phosphatases are essential for normal starch degradation in plants and glycogen metabolism in mammals. Here we develop two chromogenic methods for the detection of glucan phosphatase activity in situ after non ...

    • Adaptive Use of Bubble Wrap for Storing Liquid Samples and Performing Analytical Assays 

      Bwambok, David K.; Christodouleas, Dionysios; Morin, Stephen A.; Lange, Heiko; Phillips, Scott T.; Whitesides, George McClelland (American Chemical Society (ACS), 2014)
      This paper demonstrates that the gas-filled compartments in the packing material commonly called “bubble wrap” can be repurposed in resource-limited regions as containers to store liquid samples, and to perform bioanalyses. ...

    • Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging 

      Brink, Thore C.; Demetrius, Lloyd A.; Lehrach, Hans; Adjaye, James (Springer Netherlands, 2008)
      Individual differences in the rate of aging are determined by the efficiency with which an organism transforms resources into metabolic energy thus maintaining the homeostatic condition of its cells and tissues. This ...

    • Aggressive Parental Leave Incentivizing: A Statutory Proposal Toward Gender Equalization in the Workplace 

      Ayanna, Ariel (University of Pennsylvannia Law School, 2007)

    • Analogy Exercises for Teaching Legal Reasoning 

      Suber, Peter (Jefferson Law Book Co., 1988)

    • Ancient and Recent Adaptive Evolution of Primate Non-Homologous End Joining Genes 

      Demogines, Ann; East, Alysia M.; Lee, Ji-Hoon; Grossman, Sharon Rachel; Sabeti, Pardis Christine; Paull, Tanya T.; Sawyer, Sara L. (Public Library of Science, 2010)
      In human cells, DNA double-strand breaks are repaired primarily by the non-homologous end joining (NHEJ) pathway. Given their critical nature, we expected NHEJ proteins to be evolutionarily conserved, with relatively little ...

    • Anti-MUC1 Antibodies and Ovarian Cancer Risk: Prospective Data from the Nurses' Health Studies 

      Pinheiro, S. P.; Hankinson, Susan Elizabeth; Tworoger, Shelley Slate; Rosner, Bernard Alfred; McKolanis, J. R.; Finn, O. J.; Cramer, Daniel William (American Association for Cancer Research (AACR), 2010)
      The surface epithelial glycoprotein MUC1 becomes overexpressed and hypoglycosylated in adenocarcinomas; similar changes occur during nonmalignant inflammatory events. Antibodies developed against tumor-like MUC1 in response ...

    • Antidumping: The Third Rail of Trade Policy 

      Mankiw, N; Swagel, Phillip (Council on Foreign Relations, 2005)
      Although few U.S. politicians will admit it, antidumping policy has strayed far from its original purpose of guarding against predatory foreign firms. It is now little more than an excuse for a few powerful industries to ...

    • Application of Protein Microarrays for Multiplexed Detection of Antibodies to Tumor Antigens in Breast Cancer 

      Anderson, Karen S.; Ramachandran, Niroshan; Wong, Jessica; Raphael, Jacob V.; Hainsworth, Eugenie; Demirkan, Gokhan; Cramer, Daniel William; Aronzon, Dina; Hodi, Frank Stephen; Harris, Lyndsay; Logvinenko, Tanya; LaBaer, Joshua (American Chemical Society (ACS), 2008)
      There is strong preclinical evidence that cancer, including breast cancer, undergoes immune surveillance. This continual monitoring, by both the innate and the adaptive immune systems, recognizes changes in protein expression, ...

    • Applying GIS Methods to Public Health Research at Harvard University 

      Blossom, Jeffrey C.; Finkelstein, Julia; Guan, Wendy; Burns, Bonnie A. (Informa UK Limited, 2011)
      The Center for Geographic Analysis (CGA) at Harvard University supports research and teaching that relies on geographic information. This includes supporting geographic analysis for public health research at Harvard. This ...

    • Are Large-Scale Dams Environmentally Detrimental? Life-Cycle Environmental Consequences of Mega-Hydropower Plants in Myanmar 

      Aung, Thiri Shwesin; Fischer, Thomas B.; Azmi, Azlin Suhaida (Springer Science and Business Media LLC, 2020-07-21)
      Purpose: Rivers control biophysical processes that underpin essential ecosystem services. Myanmar’s rivers provide great opportunities for increasing energy supply at low costs from hydropower plants and make important ...

    • Are Testers Also Admitters? Comparing Emergency Physician Resource Utilization and Admitting Practices 

      Hodgson, Nicole; Saghafian, Soroush; Mi, Lanyu; Buras, Matthew; Katz, Eric; Pines, Jesse; Sanchez, Leon; Silvers, Scott; Maher, Steven; Traub, Stephen (Elsevier BV, 2018-10)
      Objective: To describe the relationship between emergency department resource utilization and admission rate at the level of the individual physician. Methods: Retrospective observational study of physician resource ...

    • Are you Going to Do That? Contingent-Payment Mechanisms to Improve Coordination 

      Ma, Hongyao; Meir, Reshef; Parkes, David C.; Zou, James (2015)
      In this extended abstract, we consider simple coordination problems, such as allocating the right to use a shared sports facility in a way that maximizes its usage, or picking the time of a meeting in a way that maximizes ...

    • Assessment of Residents’ Attitudes and Satisfaction Before and After Implementation of a Smoke-Free Policy in Boston Multiunit Housing 

      Rokicki, Slawa; Adamkiewicz, Gary; Fang, Shona C; Rigotti, Nancy Ann; Winickoff, Jonathan Philip; Levy, Douglas Edward (Oxford University Press (OUP), 2015)
      Introduction: In 2012, the Boston Housing Authority (BHA) in Massachusetts implemented a smoke-free policy prohibiting smoking within its residences. We sought to characterize BHA resident experiences before and after the ...

    • Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk 

      Lee, Alice W.; Ness, Roberta B.; Roman, Lynda D.; Terry, Kathryn Lynne; Schildkraut, Joellen M.; Chang-Claude, Jenny; Doherty, Jennifer A.; Menon, Usha; Cramer, Daniel William; Gayther, Simon A.; Risch, Harvey; Gentry-Maharaj, Aleksandra; Goodman, Marc T.; Modugno, Francesmary; Eilber, Ursula; Moysich, Kirsten B.; Berchuck, Andrew; Rossing, Mary Anne; Jensen, Allan; Wicklund, Kristine G.; Cushing-Haugen, Kara L.; Hogdall, Estrid; Rudolph, Anja; Thompson, Pamela J.; Wilkens, Lynne R.; Kjaer, Susanne K.; Carney, Michael E.; Stram, Daniel O.; Ramus, Susan J.; Wu, Anna H.; Pike, Malcolm C.; Pearce, Celeste Leigh (Ovid Technologies (Wolters Kluwer Health), 2016)
      OBJECTIVE: To describe the association between postmenopausal estrogen-only therapy use and risk of ovarian carcinoma, specifically with regard to disease histotype and duration and timing of use. METHODS: We conducted a ...

    • The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies 

      Præstegaard, Camilla; Kjaer, Susanne K.; Nielsen, Thor S.S.; Jensen, Signe M.; Webb, Penelope M.; Nagle, Christina M.; Høgdall, Estrid; Risch, Harvey A.; Rossing, Mary Anne; Doherty, Jennifer A.; Wicklund, Kristine G.; Goodman, Marc T.; Modugno, Francesmary; Moysich, Kirsten; Ness, Roberta B.; Edwards, Robert P.; Goode, Ellen L.; Winham, Stacey J.; Fridley, Brooke L.; Cramer, Daniel William; Terry, Kathryn Lynne; Schildkraut, Joellen M.; Berchuck, Andrew; Bandera, Elisa V.; Paddock, Lisa; Kiemeney, Lambertus A.; Massuger, Leon F.; Wentzensen, Nicolas; Pharoah, Paul; Song, Honglin; Whittemore, Alice S.; McGuire, Valerie; Sieh, Weiva; Rothstein, Joseph; Anton-Culver, Hoda; Ziogas, Argyrios; Menon, Usha; Gayther, Simon A.; Ramus, Susan J.; Gentry-Maharaj, Aleksandra; Wu, Anna H.; Pearce, Celeste L.; Pike, Malcolm C.; Lee, Alice W.; Chang-Claude, Jenny; Jensen, Allan (Elsevier BV, 2016)
      PURPOSE: Socioeconomic status (SES) is a known predictor of survival for several cancers and it has been suggested that SES differences affecting tumour stage at diagnosis may be the most important explanatory factor for ...