Browsing by FAS Department "Epidemiology"
Now showing items 1-9 of 9
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Determinants of Global Maternal and Neonatal Morbidity and Mortality
(2015-04-23)In 2013, approximately 289,000 women died from pregnancy-related causes and 2.8 million newborns died within the first 28 days of life. The vast majority of these deaths occur in resource-limited settings. This work examines ... -
Dietary and Reproductive Risk Factors for Breast Cancer in the Nurses' Health Studies
(2015-04-27)Breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death among US women. Several hormonal, anthropometric, lifestyle, and genetic factors are known to be associated with breast ... -
Mechanisms and Risk Factors of Cognitive Aging
(2015-04-21)This dissertation explores the role of biologic factors and a novel method of measuring cognitive function in investigating mechanisms and risk factors of cognitive aging. With a rapidly increasing aging population, the ... -
Mediation Analysis in Understanding Mechanism of Alzheimer’s Disease Risk
(2015-04-27)Although studies often show reduced risk of dementia with late-life cognitive activity, concerns about residual confounding and reverse causation cast doubt on these findings. In Chapter 1 of this dissertation, we review ... -
Meta-Analysis of a Multi-Ethnic, Breast Cancer Case-Control Targeted Sequencing Study
(2015-05-01)Breast cancer, the most commonly diagnosed cancer in American women, is a heritable disease with nearly one hundred known genetic risk factors. Using next generation sequencing, we explored the contribution of genetics at ... -
Metabolomics in Obesity and Methods for Analyzing Multiple Phenotypes
(2015-04-23)In this dissertation, we first assess the associations between circulating metabolites and body mass index in two U.S. prospective cohorts. Then, we propose several methods to analyze multiple phenotypes in genetic association ... -
Mitochondrial DNA Copy Number, Lifestyle and Cancer Risk
(2015-05-01)Mitochondria are membrane-bound organelles found in the cytoplasm of almost all eukaryotic cells. Their main functions include energy metabolism, free radical production, calcium homeostasis and apoptosis. Located closely ... -
Predictive Genetic Testing Using Common Variants: Evidence and Translation
(2015-04-28)Starting with the publication of the first genome-wide association study (GWAS) in 2005, the last decade has seen the identification of thousands of novel genetic susceptibility loci. These common, low-penetrance single ... -
Psychosocial Factors, Lifestyle and Risk of Ovarian Cancer
(2015-04-23)Current prevention recommendations for ovarian cancer are limited, and the underlying etiology is not fully elucidated. The associations of common modifiable factors, such as psychosocial and lifestyle factors, with ovarian ...