Browsing by Title
Now showing items 50229-50248 of 57074
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Systematic approaches to overcoming limitations of MAPK pathway inhibition in melanoma
(2013-10-15)Metastatic melanoma is an aggressive, incurable cancer with historically few therapeutic options. The discovery that 60% of melanomas harbor the oncogenic BRAF_V600E mutation, which constitutively activates the MAPK ... -
Systematic assessment of pharmaceutical prescriptions in association with cancer risk: a method to conduct a population-wide medication-wide longitudinal study
(Nature Publishing Group, 2016)It is a public health priority to identify the adverse and non-adverse associations between pharmaceutical medications and cancer. We search for and evaluate associations between all prescribed medications and longitudinal ... -
Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer
(National Academy of Sciences, 2016)Scleroderma is a chronic autoimmune rheumatic disease associated with widespread tissue fibrosis and vasculopathy. Approximately two-thirds of all patients with scleroderma present with three dominant autoantibody subsets. ... -
Systematic Bias and Nontransparency in US Social Security Administration Forecasts
(American Economic Association, 2015)We offer an evaluation of the Social Security Administration demographic and financial forecasts used to assess the long-term solvency of the Social Security Trust Funds. This same forecasting methodology is also used in ... -
Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction
(Public Library of Science, 2015)A fundamental challenge to contemporary genetics is to distinguish rare missense alleles that disrupt protein functions from the majority of alleles neutral on protein activities. High-throughput experimental tools to ... -
A Systematic Comparison of Motion Artifact Correction Techniques for Functional Near-Infrared Spectroscopy
(Frontiers Media S.A., 2012)Near-infrared spectroscopy (NIRS) is susceptible to signal artifacts caused by relative motion between NIRS optical fibers and the scalp. These artifacts can be very damaging to the utility of functional NIRS, particularly ... -
Systematic Consequences of Incumbency Advantage in the U.S. House Elections
(Wiley-Blackwell, 1991) -
Systematic Curation of miRBase Annotation Using Integrated Small RNA High-Throughput Sequencing Data for C. elegans and Drosophila
(Frontiers Research Foundation, 2011)MicroRNAs (miRNAs) are a class of 20–23 nucleotide small RNAs that regulate gene expression post-transcriptionally in animals and plants. Annotation of miRNAs by the miRNA database (miRBase) has largely relied on computational ... -
Systematic Differences in Impact across Publication Tracks at PNAS
(Public Library of Science, 2009)Background: Citation data can be used to evaluate the editorial policies and procedures of scientific journals. Here we investigate citation counts for the three different publication tracks of the Proceedings of the ... -
Systematic Dissection of Roles for Chromatin Regulators in a Yeast Stress Response
(Public Library of Science, 2012)Packaging of eukaryotic genomes into chromatin has wide-ranging effects on gene transcription. Curiously, it is commonly observed that deletion of a global chromatin regulator affects expression of only a limited subset ... -
Systematic evaluation and tuning of diazirine chemistry used in photoaffinity labeling
(2023-03-14)Photoaffinity labeling (PAL) is one of the few biochemical techniques that can give direct evidence of biomolecular interactions in cells. Several photoactivatable functional groups have been adapted for use in PAL since ... -
Systematic Evaluation of Factors Influencing ChIP-Seq Fidelity
(Nature Publishing Group, 2012)We performed a systematic evaluation of how variations in sequencing depth and other parameters influence interpretation of Chromatin immunoprecipitation (ChIP) followed by sequencing (ChIP-seq) experiments. Using Drosophila ... -
A Systematic Experimental and Computational Approach to Investigating Phosphotyrosine Signaling Networks
(2013-09-24)Mutation and over-expression of Receptor Tyrosine Kinases (RTKs) or the proteins they regulate serve as oncogenic drivers in diverse cancers. RTKs catalyze the transfer of phosphate from ATP to the hydroxyl group on tyrosine. ... -
Systematic Exploration of Synergistic Drug Pairs
(Nature Publishing Group, 2011)Drug synergy allows a therapeutic effect to be achieved with lower doses of component drugs. Drug synergy can result when drugs target the products of genes that act in parallel pathways (‘specific synergy’). Such cases of ... -
Systematic genetic nomenclature for type VII secretion systems
(Public Library of Science, 2009) -
Systematic Identification of Edited microRNAs in the Human Brain
(Cold Spring Harbor Laboratory, 2012-08)Adenosine-to-inosine (A-to-I) editing modifies RNA transcripts from their genomic blueprint. A prerequisite for this process is a double-stranded RNA (dsRNA) structure. Such dsRNAs are formed as part of the microRNA (miRNA) ... -
Systematic Identification of Synergistic Drug Pairs Targeting HIV
(2012)The systematic identification of effective drug combinations has been hindered by the unavailability of methods that can explore the large combinatorial search space of drug interactions. Here we present a multiplex screening ... -
Systematic Interrogation of CBP/p300 Dependency in Cancer
(2023-12-12)CBP and p300 are closely related paralogs that function as versatile transcriptional co-activator proteins. These paralogs function as histone acetyltransferases (HATs) and mediate canonical signaling programs by acetylating ... -
Systematic interrogation of tumor cell resistance to CAR T cell therapy in pancreatic cancer
(2022-06-06)Chimeric antigen receptor (CAR) T cell therapy has been highly successful in the treatment of B cell malignancies, with response rates ranging from 50 to 90% and many patients achieving durable complete responses. This ... -
Systematic Investigation into EndoRiftia Flagellar System Suggests Possibility of System Co-Option for Additional Functionality
(2021-08-20)The overarching goal of this study is to contribute to the development of the Candidatus Endoriftia persephone-Riftia pachyptila symbiotic association as a biological model system with a more specific goal being to ...