Now showing items 41668-41687 of 57074

    • Punctuated copy number evolution and clonal stasis in triple-negative breast cancer 

      Gao, Ruli; Davis, Alexander; McDonald, Thomas; Sei, Emi; Shi, Xiuqing; Wang, Yong; Tsai, Pei-Ching; Casasent, Anna; Waters, Jill; Zhang, Hong; Meric-Bernstam, Funda; Michor, Franziska L.; Navin, Nicholas E. (Springer Nature, 2016)
      Aneuploidy is a hallmark of breast cancer; however, our knowledge of how these complex rearrangements evolve during tumorigenesis is limited. In this study we developed a highly-multiplexed single-nucleus-sequencing ...
    • Punctuated Shutdown of Atlantic Meridional Overturning Circulation during Greenland Stadial 1 

      Hogg, Alan; Southon, John; Turney, Chris; Palmer, Jonathan; Bronk Ramsey, Christopher; Fenwick, Pavla; Boswijk, Gretel; Friedrich, Michael; Helle, Gerhard; Hughen, Konrad; Jones, Richard; Kromer, Bernd; Noronha, Alexandra; Reynard, Linda; Staff, Richard; Wacker, Lukas (Nature Publishing Group, 2016)
      The Greenland Stadial 1 (GS-1; ~12.9 to 11.65 kyr cal BP) was a period of North Atlantic cooling, thought to have been initiated by North America fresh water runoff that caused a sustained reduction of North Atlantic ...
    • Punctures for theories of class SΓ 

      Heckman, Jonathan J.; Jefferson, Patrick; Rudelius, Tom; Vafa, Cumrun (Springer Verlag, 2017)
      With the aim of understanding compactifications of 6D superconformal field theories to four dimensions, we study punctures for theories of class S?. The class S? theories arise from M5-branes probing C-2/Gamma, an ADE ...
    • Punishment’s Place: The Local Concentration of Mass Incarceration 

      Sampson, Robert J.; Loeffler, Charles (American Academy of Arts and Sciences, 2010)
    • The purchases of a seventeenth-century librarian 

      Salem, Adriana R. (Harvard Library, 1947)
    • Pure and conformal CVD nickel and nickel monosilicide in high-aspect-ratio structures analyzed by atom probe tomography 

      Li, Kecheng; Feng, Jun; Kwak, Junkeun; Yang, Jing; Gordon, Roy Gerald (AIP Publishing, 2017)
      Low-resistance and uniform contacts are needed for modern 3-D silicon transistors. The formation of high-quality and conformal nickel silicide at the interface between silicon and metal contacts is a possible solution. ...
    • Pure Samples of Quark and Gluon Jets at the LHC 

      Gallicchio, Jason; Schwartz, Matthew D (Springer Verlag, 2011)
      Having pure samples of quark and gluon jets would greatly facilitate the study of jet properties and substructure, with many potential standard model and new physics applications. To this end, we consider multijet and ...
    • Purification and characterization of checkpoint blockade enhancing molecules from Coprobacillus cateniformis. 

      Daugherty, Jason (2023-12-19)
      Checkpoint blockade treatment enhancement is one of the frontline areas of study in cancer treatment, however it comes with two large drawbacks, the limited number of cancer lines in which efficacy is shown and the difficulty ...
    • Purification and characterization of heparin-binding endothelial cell growth factors. 

      Lobb, Roy; Sasse, Joachim; Sullivan, Robert; Shing, Yuen; D'Amore, Patricia Ann; Jacobs, Jeffrey; Klagsbrun, Michael (American Society for Biochemistry and Molecular Biology, 1986)
    • Purification of germline stem cells from adult mammalian ovaries: a step closer towards control of the female biological clock? 

      Tilly, Jonathan Lee; Telfer, Evelyn E. (Oxford University Press, 2009)
      For decades it was believed that a non-renewable pool of oocyte-containing follicles is established in female mammals at birth. This cornerstone of reproductive biology was challenged 5 years ago by a study reporting on ...
    • Purification of Mammalian Vimentin via the Reassembly of BJ5TAa IF Method 

      Puck, Elizabeth A (2023-04-28)
      The protein vimentin is an intermediate filament and is part of the cytoskeleton in cells and tissues. The cytoskeleton is comprised of three total protein-based components that undergo liquid-liquid phase separation ...
    • Purification of α-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity 

      Luth, Eric S.; Bartels, Tim; Dettmer, Ulf; Kim, Nora C.; Selkoe, Dennis J. (American Chemical Society, 2014)
      Despite two decades of research, the structure–function relationships of endogenous, physiological forms of α-synuclein (αSyn) are not well understood. Most in vitro studies of this Parkinson’s disease-related protein have ...
    • A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates 

      Blin, Guillaume; Nury, David; Stefanovic, Sonia; Neri, Tui; Guillevic, Oriane; Brinon, Benjamin; Bellamy, Valérie; Rücker-Martin, Catherine; Barbry, Pascal; Bel, Alain; Bruneval, Patrick; Cowan, Chad A.; Pouly, Julia; Mitalipov, Shoukhrat; Gouadon, Elodie; Binder, Patrice; Hagège, Albert; Desnos, Michel; Renaud, Jean-François; Menasché, Philippe; Pucéat, Michel (American Society for Clinical Investigation, 2010)
      Cell therapy holds promise for tissue regeneration, including in individuals with advanced heart failure. However, treatment of heart disease with bone marrow cells and skeletal muscle progenitors has had only marginal ...
    • Purine and pyrimidine metabolism: Convergent evidence on chronic antidepressant treatment response in mice and humans 

      Park, Dong Ik; Dournes, Carine; Sillaber, Inge; Uhr, Manfred; Asara, John M.; Gassen, Nils C.; Rein, Theo; Ising, Marcus; Webhofer, Christian; Filiou, Michaela D.; Müller, Marianne B.; Turck, Christoph W. (Nature Publishing Group, 2016)
      Selective Serotonin Reuptake Inhibitors (SSRIs) are commonly used drugs for the treatment of psychiatric diseases including major depressive disorder (MDD). For unknown reasons a substantial number of patients do not show ...
    • Purinergic P2Y12 Receptor Activation in Eosinophils and the Schistosomal Host Response 

      Muniz, Valdirene S.; Baptista-dos-Reis, Renata; Benjamim, Claudia F.; Mata-Santos, Hilton A.; Pyrrho, Alexandre S.; Strauch, Marcelo A.; Melo, Paulo A.; Vicentino, Amanda R. R.; Silva-Paiva, Juliana; Bandeira-Melo, Christianne; Weller, Peter F.; Figueiredo, Rodrigo T.; Neves, Josiane S. (Public Library of Science, 2015)
      Identifying new target molecules through which eosinophils secrete their stored proteins may reveal new therapeutic approaches for the control of eosinophilic disorders such as host immune responses to parasites. We have ...
    • The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity 

      Kook, S H; Cho, J S; Morrison, A; Wiener, E; Lee, S B; Scadden, D; Lee, B-C (Nature Publishing Group, 2013)
      In utero exposure of the embryo and fetus to radiation has been implicated in malformations or fetal death, and often produces lifelong health consequences such as cancers and mental retardation. Here we demonstrate that ...
    • Purinergic Signaling as a Regulator of Th17 Cell Plasticity 

      Fernández, Dominique; Flores-Santibáñez, Felipe; Neira, Jocelyn; Osorio-Barrios, Francisco; Tejón, Gabriela; Nuñez, Sarah; Hidalgo, Yessia; Fuenzalida, Maria Jose; Meza, Daniel; Ureta, Gonzalo; Lladser, Alvaro; Pacheco, Rodrigo; Acuña-Castillo, Claudio; Guixé, Victoria; Quintana, Francisco J.; Bono, Maria Rosa; Rosemblatt, Mario; Sauma, Daniela (Public Library of Science, 2016)
      T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving ...
    • The Puritan Art World 

      LaFountain, Jason David (2013-09-04)
      In this dissertation, I argue that the iconoclastic and anti-materialistic "art of living to God" is the central theoretical preoccupation of English and American Puritan intellectuals. I call attention to a wealth of ...
    • Puromycin-sensitive Aminopeptidase Protects Against Aggregation-prone Proteins via Autophagy 

      Menzies, Fiona M.; Hourez, Raphael; Imarisio, Sara; Raspe, Marcel; Sadiq, Oana; Chandraratna, Dhia; O'Kane, Cahir; Rock, Kenneth L.; Reits, Eric; Rubinsztein, David C.; Goldberg, Alfred L. (Oxford University Press, 2010)
      A major function of proteasomes and macroautophagy is to eliminate misfolded potentially toxic proteins. Mammalian proteasomes, however, cannot cleave polyglutamine (polyQ) sequences and seem to release polyQ-rich peptides. ...
    • Purple Displaces Crimson: The Wakan Dialectic as Polemic 

      McCormick, Melissa
      The cultural phenomenon known as wakan, the creative juxtaposition of Japanese (wa) and Chinese (kan) elements, can be difficult to articulate given the ambiguity involved in defining the boundaries of what makes something ...