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Now showing items 37447-37466 of 57070
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Overcoming Rational Manipulation in Distributed Mechanism Implementations
(2003)Distributed systems are increasingly made up of nodes governed by disparate self-interested parties. These parties can be modeled as rational (in a game theoretic sense) utility-maximizing players that participate in a ... -
Overcoming Remoteness in the Peruvian Amazonia: A Growth Diagnostic of Loreto
(Center for International Development at Harvard University, 2022-10)Is there a tradeoff between environmental sustainability and economic development? If there is a place where that question can be approximated, that is Loreto. Located on the western flank of the Amazon jungle, Loreto is ... -
Overcoming the Challenges to the Implementation of Green Chemistry
(Center for International Development at Harvard University, 2007)The Harvard-Yale-ACS GCI Green Chemistry Project is investigating the overall question of the circumstances under which firms can enact innovations that have both economic and environmental benefits, through a focused ... -
Overcoming the Curse: Statistical Theory and Methods in High Dimensions
(2021-05-07)Battling the curse of dimensionality is a common theme in modern statistics. This dissertation contributes to this effort by surveying theory and methods in high-dimensinonal statistics developed by the author and ... -
Overcoming the fear of lethal injury: Evaluating suicidal behavior in the military through the lens of the Interpersonal–Psychological Theory of Suicide
(Elsevier BV, 2010)Suicide rates have been increasing in military personnel since the start of Operation Enduring Freedom and Operation Iraqi Freedom, and it is vital that efforts be made to advance suicide risk assessment techniques and ... -
Overcoming the Global Despondency Trap: Strengthening Corporate Accountability in Supply Chains
(Center for International Development at Harvard University, 2019-10)This paper re-examines why global collective action problems persist, and how to overcome them. Drawing on 140 interviews with campaigners, politicians, and businesses in 10 European countries, it suggests that many activists ... -
Overcoming the limits of institutional reform in Uganda
(Center for International Development at Harvard University, 2013-10)This paper begins by noting that Uganda has been a public sector reform leader in Africa. It has pursued reforms actively and consistently for three decades now, and has produced many laws, processes and structures that ... -
Overcoming Trivialities: Gossiping, Note-Taking, and the Problem of Information in Thirteenth-century China
(2021-09-10)This dissertation studies the social and cultural history of information collection and circulation in Song China (960-1276). Focusing on literati’s writing of the notebook (biji) genre in the thirteenth century, this ... -
Overdose rescues by trained and untrained participants and change in opioid use among substance-using participants in overdose education and naloxone distribution programs: a retrospective cohort study
(BioMed Central, 2014)Background: One approach to preventing opioid overdose, a leading cause of premature, preventable mortality, is to provide overdose education and naloxone distribution (OEND). Two outstanding issues for OEND implementation ... -
Overestimates of Survival after HAART: Implications for Global Scale-Up Efforts
(Public Library of Science, 2008)Background: Monitoring the effectiveness of global antiretroviral therapy scale-up efforts in resource-limited settings is a global health priority, but is complicated by high rates of losses to follow-up after treatment ... -
Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation
(Oxford University Press, 2016)ATF4 is a pro-oncogenic transcription factor whose translation is activated by eIF2 phosphorylation through delayed re-initiation involving two uORFs in the mRNA leader. However, in yeast, the effect of eIF2 phosphorylation ... -
Overexpression of heterogeneous nuclear ribonucleoprotein F stimulates renal Ace-2 gene expression and prevents TGF-β1-induced kidney injury in a mouse model of diabetes
(Springer Berlin Heidelberg, 2015)Aims/hypothesis We investigated whether heterogeneous nuclear ribonucleoprotein F (hnRNP F) stimulates renal ACE-2 expression and prevents TGF-β1 signalling, TGF-β1 inhibition of Ace-2 gene expression and induction of ... -
Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma
(Impact Journals LLC, 2015)Melanoma harboring BRAF mutations frequently develop resistance to BRAF inhibitors, limiting the impact of treatment. Here, we establish a mechanism of resistance and subsequently identified a suitable drug combination to ... -
Overexpression of N-Myc Downstream-Regulated Gene 2 (NDRG2) Regulates the Proliferation and Invasion of Bladder Cancer Cells In Vitro and In Vivo
(Public Library of Science, 2013)N-Myc downstream-regulated gene 2 (NDRG2) is a candidate tumor suppressor gene, which plays an important role in controlling tumor growth. The aim of this study was to investigate the expression of NDRG2 gene in bladder ... -
Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level
(National Academy of Sciences, 2006)Rad is a low molecular weight GTPase that is overexpressed in skeletal muscle of some patients with type 2 diabetes mellitus and/or obesity. Overexpression of Rad in adipocytes and muscle cells in culture results in ... -
Overinvestment, Collateral Lending, and Economic Crisis
(1999-03)This paper presents a model in which a high growth economy becomes susceptible to a sudden financial crisis. In the model firms are motivated to over-invest because of government subsidies and then bear the burden of the ... -
The Overlap Syndrome of Depression and Delirium in Older Hospitalized Patients
(Wiley-Blackwell, 2009)OBJECTIVES: To measure the prevalence, predictors, and posthospitalization outcomes associated with the overlap syndrome of coexisting depression and incident delirium in older hospitalized patients. DESIGN: Secondary ... -
An Overlapping Generations Model of Electoral Competition
(Elsevier, 1988) -
Overlapping representations for grip type and reach direction
(Elsevier, 2014) -
Overlapping Splicing Regulatory Motifs—Combinatorial Effects on Splicing
(Oxford University Press, 2010)Regulation of splicing in eukaryotes occurs through the coordinated action of multiple splicing factors. Exons and introns contain numerous putative binding sites for splicing regulatory proteins. Regulation of splicing ...