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Now showing items 35923-35942 of 57070
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Nuclear spin singlet states as a contrast mechanism for NMR spectroscopy
(Wiley-Blackwell, 2013)Nuclear magnetic resonance (NMR) spectra of complex chemical mixtures often contain unresolved or hidden spectral components, especially when strong background signals overlap weaker peaks. In this article we demonstrate ... -
Nuclear Terrorism Fact Sheet
(Belfer Center for Science and International Affairs - Harvard Kennedy School, 2010) -
Nuclear Terrorism: Threat Briefing. How Serious is the Threat?
(Belfer Center for Science and International Affairs - Harvard Kennedy School, 2010) -
Nuclear war between Israel and Iran: lethality beyond the pale
(Springer Nature, 2013)Background: The proliferation of nuclear technology in the politically volatile Middle East greatly increases the likelihood of a catastrophic nuclear war. It is widely accepted, while not openly declared, that Israel has ... -
Nuclear War in the Middle East: Where is the Voice of Medicine and Public Health?
(Cambridge University Press (CUP), 2011)Once again, the politically volatile Middle East and accompanying rhetoric has escalated the risk of a major nuclear exchange. Diplomatic efforts have failed to make the medical consequences of such an exchange a leading ... -
The Nuclear Weapons Complexes: Meeting the Conversion Challenge -- A Proposal for Expanded Action
(Russian-American Nuclear Security Advisory Council., 1997)Since the end of the Cold War, the United States and Russia have undertaken a serious effort to convert their nuclear complexes to non-weapons work. However, it has been difficult to achieve significant progress toward ... -
Nucleation and Growth of HNO3.3H2O Particles in the Polar Stratosphere
(American Meteorological Society, 1990)Growth of nitric acid trihydrate (NAT) particles on background stratospheric aerosols is examined for an isolated air parcel cooled at a uniform rate. The free energy barrier against nucleation and rates of cooling are ... -
Nucleation and Transport Organize Microtubules in Metaphase Spindles
(Elsevier BV, 2012)Spindles are arrays of microtubules that segregate chromosomes during cell division. It has been difficult to validate models of spindle assembly due to a lack of information on the organization of microtubules in these ... -
Nucleation behavior of melted Bi films at cooling rates from 101 to 104K/s studied by combining scanning AC and DC nano-calorimetry techniques
(Elsevier BV, 2015)We study the nucleation behavior of undercooled liquid Bi at cooling rates ranging from 101 to 104 K/s using a combination of scanning DC and AC nano-calorimetry techniques. Upon initial melting, the Bi thin-film sample ... -
Nucleation of Slip-Weakening Rupture Instability in Landslides by Localized Increase of Pore Pressure
(American Geophysical Union, 2012)We model landslide initiation as slip surface growth driven by local elevated pore pressure, with particular reference to submarine slides. Assuming an elastic medium and friction that weakens with slip, solutions exist ... -
The Nucleoid Binding Protein H-NS Biases Genome-Wide Transposon Insertion Landscapes
(American Society for Microbiology, 2016)ABSTRACT Transposon insertion sequencing (TIS; also known as TnSeq) is a potent approach commonly used to comprehensively define the genetic loci that contribute to bacterial fitness in diverse environments. A key presumption ... -
Nucleolin Associates with the Human Cytomegalovirus DNA Polymerase Accessory Subunit UL44 and Is Necessary for Efficient Viral Replication
(American Society for Microbiology, 2010)In the eukaryotic cell, DNA replication entails the interaction of multiple proteins with the DNA polymerase processivity factor PCNA. As the structure of the presumptive human cytomegalovirus (HCMV) DNA polymerase ... -
Nucleolin Interacts with Telomerase
(American Society for Biochemistry and Molecular Biology, 2004)Telomerase is a specialized reverse transcriptase composed of core RNA and protein subunits which plays essential roles in maintaining telomeres in actively dividing cells. Recent work indicates that telomerase shuttles ... -
Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity
(Public Library of Science, 2013)Lentiviruses can infect non-dividing cells, and various cellular transport proteins provide crucial functions for lentiviral nuclear entry and integration. We previously showed that the viral capsid (CA) protein mediated ... -
Nucleoside and RNA Triphosphatase Activities of Orthoreovirus Transcriptase Cofactor μ2
(American Society for Biochemistry and Molecular Biology, 2004)The mammalian Orthoreovirus (mORV) core particle is an icosahedral multienzyme complex for viral mRNA synthesis and provides a delimited system for mechanistic studies of that process. Previous genetic results have identified ... -
Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming
(2014)Chromatin structure determines DNA accessibility. We compare nucleosome occupancy in mouse and human embryonic stem cells (ESCs), induced-pluripotent stem cells (iPSCs), and differentiated cell types using MNase-seq. To ... -
Nucleosome Assembly Is Required for Nuclear Pore Complex Assembly in Mouse Zygotes
(Springer Nature, 2014)Packaging of DNA into nucleosomes not only helps to store genetic information but also creates diverse means for regulating DNA-templated processes. Attempts to reveal additional functions of the nucleosome have been ... -
Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains
(2013)The ISWI family of ATP-dependent chromatin remodelers represses transcription by changing nucleosome positioning. The interactions with extranucleosomal DNA and the requirement of a minimal length of extranucleosomal DNA ... -
Nucleotide Modifications of RNA Suppress RIG-I Antiviral Signaling by Unique Mechanisms
(2016-05-02)In order to counter pathogen infection while preventing autoimmune responses, the human innate immune system must be precisely regulated to distinguish “self” from “non-self”. Pattern recognition receptors detect “non-self” ... -
Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities
(American Society for Microbiology, 2009)Cytoplasmic viral RNAs with 5' triphosphates (5'ppp) are detected by the RNA helicase RIG-I, initiating downstream signaling and alpha/beta interferon (IFN-alpha/beta) expression that establish an antiviral state. We ...