Browsing by Title

Now showing items 30231-30250 of 57116

    • Low’s Subleading Soft Theorem as a Symmetry of QED 

      Lysov, Vyacheslav; Pasterski, Sabrina; Strominger, Andrew E. (American Physical Society (APS), 2014)
      It was shown by F. Low in the 1950s that the subleading terms of soft photon S-matrix elements obey a universal linear relation. In this paper we give a new interpretation to this old relation, for the case of massless ...

    • Lp-PLA 2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative MacrophagesCLINICAL PERSPECTIVE 

      He, Shun; Chousterman, Benjamin; Fenn, Ashley Margaret; Anzai, Atsushi; Nairz, Manfred; Brandt, Martin; Hilgendorf, Ingo; Sun, Yuan; Ye, Yu-Xiang; Iwamoto, Yoshiko; Tricot, Benoit; Weissleder, Ralph; Macphee, Colin; Libby, Peter; Nahrendorf, Matthias; Swirski, Filip K. (Ovid Technologies (Wolters Kluwer Health), 2015)
      Background—Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6Chigh and reparative Ly-6Clow monocytes/macrophages. Excessive inflammation disrupts the balance between the 2 ...

    • Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages 

      He, Shun; Chousterman, Benjamin G.; Fenn, Ashley; Anzai, Atsushi; Nairz, Manfred; Brandt, Martin; Hilgendorf, Ingo; Sun, Yuan; Ye, Yu-Xiang; Iwamoto, Yoshiko; Tricot, Benoit; Weissleder, Ralph; Macphee, Colin; Libby, Peter; Nahrendorf, Matthias; Swirski, Filip K. (Lippincott Williams & Wilkins, 2015)
      Background— Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6Chigh and reparative Ly-6Clow monocytes/macrophages. Excessive inflammation disrupts the balance between the 2 ...

    • LPA5 Is Abundantly Expressed by Human Mast Cells and Important for Lysophosphatidic Acid Induced MIP-1β Release 

      Lundequist, Anders; Boyce, Joshua A. (Public Library of Science, 2011)
      Background: Lysophosphatidic acid (LPA) is a bioactive lipid inducing proliferation, differentiation as well as cytokine release by mast cells through G-protein coupled receptors. Recently GPR92/LPA5 was identified as an ...

    • Lpt-protein dynamics reveal that Lipopolysaccharide promotes trans-envelope bridge formation 

      Toerk, Lisa (2022-09-09)
      Gram-negative bacteria have two lipid bilayers, the inner membrane and the outer membrane as part of their cell envelope structure.1 A special feature of the outer layer is its asymmetric membrane structure, comprised of ...

    • LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair 

      Liu, Xue-Song; Chandramouly, Gurushankar; Rass, Emilie; Guan, Yinghua; Wang, Guocan; Hobbs, Robin M.; Rajendran, Anbazhagan; Xie, Anyong; Shah, Jagesh V.; Davis, Anthony J.; Scully, Ralph; Lunardi, Andrea; Pandolfi, Pier Paolo (Nature Pub. Group, 2015)
      Leukemia/lymphoma-related factor (LRF) is a POZ/BTB and Krüppel (POK) transcriptional repressor characterized by context-dependent key roles in cell fate decision and tumorigenesis. Here we demonstrate an unexpected ...

    • Lrf suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion 

      Wang, Guocan; Lunardi, Andrea; Zhang, Jiangwen; Chen, Zhenbang; Ala, Ugo; Webster, Kaitlyn A.; Tay, Yvonne; Gonzalez-Billalabeitia, Enrique; Egia, Ainara; Shaffer, David R.; Carver, Brett; Liu, Xue-Song; Taulli, Riccardo; Kuo, Winston Patrick; Nardella, Caterina; Signoretti, Sabina; Cordon-Cardo, Carlos; Gerald, William L.; Pandolfi, Pier Paolo (2013)
      Lrf has been previously described as a powerful proto-oncogene. Here we surprisingly demonstrate that Lrf plays a critical oncosuppressive role in the prostate. Prostate specific inactivation of Lrf leads to a dramatic ...

    • LRP1 Is a Master Regulator of Tau Uptake and Spread 

      Rauch, Jennifer; Luna, Gabriel; Guzman, Elmer; Andouard, Morgane; Challis, Collin; Sibih, Youssef; LeShuk, Carolina; Wegmann, Susanna; Hyman, Bradley; Gradinaru, Viviana; Kampmann, Martin; Kosik, Kenneth S. (Wiley, 2020-04-16)
      The spread of protein aggregates during disease progression is a common theme underlying many neurodegenerative diseases. The microtubule-associated protein tau (MAPT) plays a central role in the pathogenesis of several ...

    • LRP5 Regulates Development of Lung Microvessels and Alveoli through the Angiopoietin-Tie2 Pathway 

      Mammoto, Tadanori; Jiang, Amanda Rose; Jiang, Elizabeth Qingyu; Mammoto, Akiko; Chen, Jing; Smith, Lois Elaine Hodgson; Ingber, Donald Elliott (Public Library of Science, 2012)
      Angiogenesis is crucial for lung development. Although there has been considerable exploration, the mechanism by which lung vascular and alveolar formation is controlled is still not completely understood. Here we show ...

    • LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice 

      Kim, Jeesun; Singh, Anup Kumar; Takata, Yoko; Lin, Kevin; Shen, Jianjun; Lu, Yue; Kerenyi, Marc A.; Orkin, Stuart H.; Chen, Taiping (Nature Publishing Group, 2015)
      Mammalian oocytes are arrested at prophase I until puberty when hormonal signals induce the resumption of meiosis I and progression to meiosis II. Meiotic progression is controlled by CDK1 activity and is accompanied by ...

    • LSD1-mediated Grob-like fragmentation as a novel drug resistance mechanism 

      Tuttle-Vasseur, Paloma (2023-09-11)
      Small molecules are powerful tools to illuminate biological functions and have played an instrumental role in making seminal discoveries in chromatin biology. Dysregulation of epigenetic states has been directly implicated ...

    • Lspm J1112+7626: Detection of a 41 Day M-dwarf Eclipsing Binary From the Mearth Transit Survey 

      Irwin, Jonathan M.; Quinn, Samuel N.; Berta, Zachory K.; Latham, David W.; Torres, Guillermo; Burke, Christopher J.; Charbonneau, David; Dittmann, Jason; Esquerdo, Gilbert A.; Stefanik, Robert P.; Oksanen, Arto; Buchhave, Lars A.; Nutzman, Philip; Berlind, Perry; Calkins, Michael L.; Falco, Emilio E. (American Astronomical Society, 2011)
      We report the detection of eclipses in LSPM J1112+7626, which we find to be a moderately bright (I-C = 12.14 +/- 0.05) very low mass binary system with an orbital period of 41.03236 +/- 0.00002 days, and component masses ...

    • LSTM Networks Can Perform Dynamic Counting 

      Suzgun, Mirac; Gehrmann, Sebastian; Belinkov, Yonatan; Shieber, Stuart (2019-06-09)
      In this paper, we systematically assess the ability of standard recurrent networks to perform dynamic counting and to encode hierarchical representations. All the neural models in our experiments are designed to be small-sized ...

    • LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma 

      Kazani, Shamsah; Arm, Jonathan P; Boyce, Joshua; Chhay, Heng; Dutile, Stefanie; Wechsler, Michael E; Govindarajulu, Usha; Ivester, Priscilla; Ainsworth, Hannah C; Sergeant, Susan; Chilton, Floyd H; Israel, Elliot (Springer International Publishing, 2014)
      Botanical seed oils reduce the generation of leukotrienes in patients with asthma. Our objective was to determine the efficacy of a botanical seed oil combination against airflow obstruction in asthma, and to determine the ...

    • Lubiprostone Increases Small Intestinal Smooth Muscle Contractions Through a Prostaglandin E Receptor 1 (EP1)-mediated Pathway 

      Chan, Walter W; Mashimo, Hiroshi (Korean Society of Neurogastroenterology and Motility, 2013)
      Background/Aims Lubiprostone, a chloride channel type 2 (ClC-2) activator, was thought to treat constipation by enhancing intestinal secretion. It has been associated with increased intestinal transit and delayed gastric ...

    • Lubricant-infused micro/nano-structured surfaces with tunable dynamic omniphobicity at high temperatures 

      Daniel, Dan; Mankin, Max Nathan; Belisle, Rebecca A.; Wong, Tak-Sing; Aizenberg, Joanna (AIP Publishing, 2013)
      Omniphobic surfaces that can repel fluids at temperatures higher than 100 °C are rare. Most state-of-the-art liquid-repellent materials are based on the lotus effect, where a thin air layer is maintained throughout ...

    • Lubricant-Infused Nanoparticulate Coatings Assembled by Layer-by-Layer Deposition 

      Sunny, Steffi; Vogel, Nicolas; Howell, Caitlin; Vu, Thy L.; Aizenberg, Joanna (Wiley, 2014)
      Omniphobic coatings are designed to repel a wide range of liquids without leaving stains on the surface. A practical coating should exhibit stable repellency, show no interference with color or transparency of the underlying ...

    • Lubricated Immersed Boundary Method in Two Dimensions 

      Fai, Thomas; Rycroft, Christopher (Elsevier BV, 2018-03)
      Many biological examples of fluid–structure interaction, including the transit of red blood cells through the narrow slits in the spleen and the intracellular trafficking of vesicles into dendritic spines, involve the ...

    • Lubricin Distribution in the Menisci and Labra of Human Osteoarthritic Joints 

      Zhang, Dafang; Cheriyan, Thomas; Martin, Scott D.; Schmid, Thomas M.; Spector, Myron (SAGE Publications, 2012)
      Objective: Lubricin is the principal boundary lubricant on articular cartilage. We aimed to describe the distribution of lubricin in the other articulating structures in the human knee and hip—menisci and labra—and to ...

    • Lubricin Protects the Temporomandibular Joint Surfaces from Degeneration 

      Hill, Adele; Duran, Juanita; Purcell, Patricia (Public Library of Science, 2014)
      The temporomandibular joint (TMJ) is a specialized synovial joint essential for the mobility and function of the mammalian jaw. The TMJ is composed of the mandibular condyle, the glenoid fossa of the temporal bone, and a ...