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Now showing items 28417-28436 of 57070
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Kinetics of Facultative Heterochromatin and Polycomb Group Protein Association with the Herpes Simplex Viral Genome during Establishment of Latent Infection
(American Society of Microbiology, 2013)ABSTRACT The herpes simplex virus (HSV) genome is associated with heterochromatic histone modifications, including trimethylation of the lysine 27 residue of histone H3 (H3K27me3), during latent infection of neurons. Here ... -
Kinetics of Hydrogen Atom Abstraction from Substrate by an Active Site Thiyl Radical in Ribonucleotide Reductase
(American Chemical Society, 2014)Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides in all organisms. Active E. coli class Ia RNR is an α2β2 complex that undergoes reversible, long-range proton-coupled electron ... -
Kinetics of Hydrogen Atom Abstraction from Substrate by an Active Site Thiyl Radical in Ribonucleotide Reductase
(American Chemical Society, 2014)Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides in all organisms. Active E. coli class Ia RNR is an α2β2 complex that undergoes reversible, long-range proton-coupled electron ... -
Kinetics of Proton Transport into Influenza Virions by the Viral M2 Channel
(Public Library of Science, 2012)M2 protein of influenza A viruses is a tetrameric transmembrane proton channel, which has essential functions both early and late in the virus infectious cycle. Previous studies of proton transport by M2 have been limited ... -
Kinetics of solid-gas reactions characterized by scanning AC nano-calorimetry with application to Zr oxidation
(AIP Publishing, 2014)Scanning AC nano-calorimetry is a recently developed experimental technique capable of measuring the heat capacity of thin-film samples of a material over a wide range of temperatures and heating rates. Here, we describe ... -
The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes
(BMJ Publishing Group, 2015)Background: Mutations in microtubule-regulating genes are associated with disorders of neuronal migration and microcephaly. Regulation of centriole length has been shown to underlie the pathogenesis of certain ciliopathy ... -
The King's Theatre: Ballet and Italian Opera in London, 1706-1883
(Harvard Library, Houghton Library, 2003) -
Kingly Exchange: The Silk Road and the East Eurasian World in the Age of Fragmentation (850-1000)
(2017-05-13)This dissertation is a cultural history of travel on the Silk Road in East Eurasia in the ninth and tenth centuries from the vantage point of Dunhuang, an oasis town situated between China proper and Central Asia. Following ... -
Kinked p–n Junction Nanowire Probes for High Spatial Resolution Sensing and Intracellular Recording
(American Chemical Society, 2012)Semiconductor nanowires and other semiconducting nanoscale materials configured as field-effect transistors have been studied extensively as biological/chemical (bio/chem) sensors. These nanomaterials have demonstrated ... -
Kino-Eye, Kino-Bayonet: The Avant-Garde Documentary in Japan, France, and the USSR
(2017-09-08)This dissertation considers a grouping of films in the former USSR, France, and Japan from the perspective of the political aesthetics they aim to create. These films, usually considered avant-garde documentaries, provide ... -
Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy
(BioMed Central, 2014)Background: High-grade osteosarcoma is a primary malignant bone tumor mostly occurring in adolescents and young adults, with a second peak at middle age. Overall survival is approximately 60%, and has not significantly ... -
Kinship Asymmetries and the Divided Self
(Cambridge University Press, 2008)Imprinted genes are predicted to affect interactions among relatives. Therefore, variant alleles at imprinted loci are promising candidates for playing a causal role in disorders of social behavior. The effects of imprinted ... -
Kirigami-inspired stents for sustained local delivery of therapeutics
(Springer Science and Business Media LLC, 2021-06-14)Implantable drug depots have the capacity to locally meet therapeutic requirements by maximizing local drug efficacy and minimizing potential systemic side effects. Tubular organs including the gastrointestinal tract, ... -
Kirill Borisovich Tolpygo: Teacher, Advisor and Scientist
(American Institute of Physics, 2016) -
Kirkuk, 1918-1968: Oil and the Politics of Identity in an Iraqi City
(2012-11-07)In this dissertation, I use methodological approaches from studies of urbanism, oil modernity, nation building, and identity formation to analyze the relationships between urban change, oil, state integration, and the ... -
Kisaeng: A Sociopolitical History of Entertainment Labor in Korea, 1900–1950
(2023-06-01)This dissertation is a labor history of the early-twentieth-century kisaeng, a class of women entertainers in Korea whose labor comprised a fluid combination of musical performance and sexual commerce. While the figure of ... -
KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma
(Massachusetts Medical Society, 2017-05-17)BACKGROUND: Mast cells are present in the airways of patients who have severe asthma despite glucocorticoid treatment; these cells are associated with disease characteristics including poor quality of life and inadequate ... -
The Kitaev–Feynman Clock for Open Quantum Systems
(IOP Publishing, 2014)We show that Kitaevʼs construction of Feynmanʼs clock, in which the time-evolution of a closed quantum system is encoded as a ground state problem, can be extended to open quantum systems. In our formalism, the ground ... -
Kitāb al-Rimāḥ of ‘Umar Fūtī Tāl: Sealing Muhammadan Sainthood in Nineteenth Century West Africa
(2022-03-17)This dissertation offers an in-depth exploration of the key themes, sources and contributions of Kitāb Rimāḥ ḥizb al-Raḥīm ‘alā nūḥūr ḥizb al-rajīm; West Africa’s “most widely circulated text” written by Shaykh ‘Umar Fūtī ... -
The kitchen as a physics classroom
(IOP Publishing, 2014-09)Cooking is a tangible, familiar, and delicious tool for teaching physics, which is easy to implement in a university setting. Through our courses at Harvard and UCLA, each year we are engaging hundreds of undergraduate ...