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Now showing items 24355-24374 of 57070
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Hypertrophic cardiomyopathy: Translating cellular cross talk into therapeutics
(The Rockefeller University Press, 2012)Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with serious adverse outcomes, including heart failure, arrhythmias, and sudden cardiac death. The discovery that mutations in sarcomere protein genes ... -
Hypertrophic Pachymeningitis and Cerebral Venous Sinus Thrombosis in Inflammatory Bowel Disease
(Elsevier BV, 2010-11)Hypertrophic pachymeningitis is rarely observed in inflammatory bowel disease. We report a woman with ulcerative colitis whose biopsy-confirmed hypertrophic pachymeningitis was complicated by cerebral venous sinus thrombosis ... -
Hypervelocity collisions of binary stars at the Galactic Centre
(Oxford University Press, 2007)Recent surveys have identified seven hypervelocity stars (HVSs) in the halo of the Milky Way. Most of these stars may have originated from the breakup of binary star systems by the nuclear black hole SgrA*. In some instances, ... -
Hypervelocity planets and transits around hypervelocity stars
(Oxford University Press, 2012)The disruption of a binary star system by the massive black hole at the Galactic Centre, SgrA*, can lead to the capture of one star around SgrA* and the ejection of its companion as a hypervelocity star (HVS). We consider ... -
Hypervelocity stars from the Andromeda galaxy
(Oxford University Press, 2008)Hypervelocity stars (HVSs) discovered in the Milky Way (MW) halo are thought to be ejected from near the massive black hole (MBH) at the Galactic centre. In this paper, we investigate the spatial and velocity distributions ... -
Hyphen - American: The Making of Hybrid Identities
(2021-05-24)ON BELONGING – DISPLACEMENT We seek to feel “in place.” However, one cannot feel a sense of belonging if there is nowhere to belong. In the 21st century, globalization has increased the mobility of people, information, ... -
Hyphenated Housing: Healthcare-Housing for those Experiencing Homelessness in LA
(2021-05-20)Hospitals are the most expensive form of housing. New research suggests that it is far more cost-effective to purchase dedicated housing for homeless patients for an entire year than to house them in a hospital bed for a ... -
Hypofractionated Radiotherapy and Stereotactic Boost with Concurrent and Adjuvant Temozolamide for Glioblastoma in Good Performance Status Elderly Patients – Early Results of a Phase II Trial
(Frontiers Media S.A., 2012)Glioblastoma Multiforme (GBM) is an aggressive primary brain neoplasm with dismal prognosis. Based on successful phase III trials, 60 Gy involved-field radiotherapy in 30 fractions over 6 weeks [Standard radiation therapy ... -
Hypoglycemia and Clinical Outcomes in Patients With Diabetes Hospitalized in the General Ward
(American Diabetes Association, 2009)OBJECTIVE: Hypoglycemia is associated with adverse outcomes in mixed populations of patients in intensive care units. It is not known whether the same risks exist for diabetic patients who are less severely ill. In this ... -
Hypoglycemia, With or Without Insulin Therapy, Is Associated With Increased Mortality Among Hospitalized Patients
(American Diabetes Association, 2013)OBJECTIVE Hypoglycemia is associated with increased mortality in hospitalized patients. We investigated the relationship between spontaneous hypoglycemia versus insulin-associated hypoglycemia and mortality in hospitalized ... -
Hypokalemia, Its Contributing Factors and Renal Outcomes in Patients with Chronic Kidney Disease
(Public Library of Science, 2013)Background: In the chronic kidney disease (CKD) population, the impact of serum potassium (sK) on renal outcomes has been controversial. Moreover, the reasons for the potential prognostic value of hypokalemia have not been ... -
Hypomethylation of the IGF2 DMR in Colorectal Tumors, Detected by Bisulfite Pyrosequencing, is Associated with Poor Prognosis
(BMC, 2010)BACKGROUND and AIMS: The insulin-like growth factor 2 (IGF2) gene is normally imprinted. Constitutive loss of imprinting (LOI) of IGF2 has been associated with increased risks of colon cancer and adenoma, indicating its ... -
Hypothalamic kappa opioid receptor mediates both diet‐induced and melanin concentrating hormone–induced liver damage through inflammation and endoplasmic reticulum stress
(John Wiley and Sons Inc., 2016)The opioid system is widely known to modulate the brain reward system and thus affect the behavior of humans and other animals, including feeding. We hypothesized that the hypothalamic opioid system might also control ... -
Hypothalamus and amygdala response to acupuncture stimuli in carpal tunnel syndrome
(Ovid Technologies (Wolters Kluwer Health), 2007)Brain processing of acupuncture stimuli in chronic neuropathic pain patients may underlie its beneficial effects. We used fMRI to evaluate verum and sham acupuncture stimulation at acupoint LI-4 in Carpal Tunnel Syndrome ... -
Hypothermia in Bleeding Trauma: A Friend or a Foe?
(BioMed Central, 2009)The induction of hypothermia for cellular protection is well established in several clinical settings. Its role in trauma patients, however, is controversial. This review discusses the benefits and complications of induced ... -
Hypothesis Testing and Model Selection for Complex Data
(2017-05-15)In this dissertation, we propose methodology for hypothesis testing in statistical genetics and model selection in networks. In chapters 1 and 2, we introduce new methods to tackle difficulties in hypothesis testing for ... -
Hypothesis Testing for High-dimensional Sparse Binary Regression
(Institute of Mathematical Statistics, 2015)In this paper, we study the detection boundary for minimax hypothesis testing in the context of high-dimensional, sparse binary regression models. Motivated by genetic sequencing association studies for rare variant effects, ... -
Hypothesis Testing in GWAS and Statistical Issues with Compensation in Clinical Trials
(2013-09-27)We first show theoretically and in simulation how power varies as a function of SNP correlation structure with currently-implemented gene-based testing methods. We propose alternative testing methods whose power does not ... -
Hypothesis-Based Analysis of Gene-Gene Interactions and Risk of Myocardial Infarction
(Public Library of Science, 2012)The genetic loci that have been found by genome-wide association studies to modulate risk of coronary heart disease explain only a fraction of its total variance, and gene-gene interactions have been proposed as a potential ... -
Hypothesis: Induced Angiogenesis after Surgery in Premenopausal Node-Positive Breast Cancer Patients Is a Major Underlying Reason Why Adjuvant Chemotherapy Works Particularly Well for Those Patients
(BioMed Central, 2004)Background: We suggest that surgical extirpation of primary breast cancer among other effects accelerates relapse for some premenopausal node-positive patients. These accelerated relapses occur within 10 months of surgery ...