Browsing by Title

Now showing items 11013-11032 of 57070

    • Cynical Soundings: the Dappled World of the Dog's Bark 

      Battles, Matthew (2017)

    • Cynicism in Negotiation: When Communication Increases Buyers’ Skepticism 

      Ert, Eyal; Creary, Stephanie; Bazerman, Max (Cambridge University Press (CUP), 2014-05)
      The economic literature on negotiation shows that strategic concerns can be a barrier to agreement, even when the buyer values the good more than the seller. Yet behavioral research demonstrates that human interaction can ...

    • CYP17 Genetic Variation and Risk of Breast and Prostate Cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) 

      Setiawan, V. W.; Schumacher, F. R.; Haiman, C. A.; Stram, D. O.; Albanes, D.; Altshuler, D.; Berglund, G.; Buring, J.; Calle, E. E.; Clavel-Chapelon, F.; Cox, D. G.; Gaziano, J. M.; Hankinson, S. E.; Hayes, R. B.; Henderson, B. E.; Hirschhorn, J. N.; Hoover, R.; Hunter, D. J.; Kaaks, R.; Kolonel, L. N.; Kraft, P.; Ma, J.; Le Marchand, L.; Linseisen, J.; Lund, E.; Navarro, C.; Overvad, K.; Palli, D.; Peeters, P. H. M.; Pike, M. C.; Riboli, E.; Stampfer, Meir; Thun, M. J.; Travis, R. C.; Trichopoulos, D.; Yeager, M.; Ziegler, R. G.; Feigelson, H. S.; Chanock, S. J. (American Association for Cancer Research, 2007)
      CYP17 encodes cytochrome p450c17 alpha, which mediates activities essential for the production of sex steroids. Common germ line variation in the CYP17 gene has been related to inconsistent results in breast and prostate ...

    • CYP19A1 genetic variation in relation to prostate cancer risk and circulating sex hormone concentrations in men from the Breast and Prostate Cancer Cohort Consortium 

      Travis, Ruth C.; Schumacher, Fredrick; Hirschhorn, Joel N.; Kraft, Peter; Allen, Naomi E.; Albanes, Demetrius; Berglund, Goran; Berndt, Sonja I.; Boeing, Heiner; Bueno-de-Mesquita, H. Bas; Calle, Eugenia E.; Chanock, Stephen; Dunning, Alison M.; Hayes, Richard; Feigelson, Heather Spencer; Gaziano, J. Michael; Giovannucci, Edward; Haiman, Christopher A.; Henderson, Brian E.; Kaaks, Rudolf; Kolonel, Laurence N.; Ma, Jing; Rodriguez, Laudina; Riboli, Elio; Stampfer, Meir; Stram, Daniel O.; Thun, Michael J.; Tjønneland, Anne; Trichopoulos, Dimitrios; Vineis, Paolo; Virtamo, Jarmo; Marchand, Loïc Le; Hunter, David J. (American Association for Cancer Research, 2009)
      Sex hormones, particularly the androgens, are important for the growth of the prostate gland and have been implicated in prostate cancer carcinogenesis, yet the determinants of endogenous steroid hormone levels remain ...

    • CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk 

      Garcia-Albeniz, Xabier; Rudolph, Anja; Hutter, Carolyn; White, Emily; Lin, Yi; Rosse, Stephanie A; Figueiredo, Jane C; Harrison, Tabitha A; Jiao, Shuo; Brenner, Hermann; Casey, Graham; Hudson, Thomas J; Thornquist, Mark; Le Marchand, Loic; Potter, John; Slattery, Martha L; Zanke, Brent; Baron, John A; Caan, Bette J; Chanock, Stephen J; Berndt, Sonja I; Stelling, Deanna; Fuchs, Charles S; Hoffmeister, Michael; Butterbach, Katja; Du, Mengmeng; James Gauderman, W; Gunter, Marc J; Lemire, Mathieu; Ogino, Shuji; Lin, Jennifer; Hayes, Richard B; Haile, Robert W; Schoen, Robert E; Warnick, Greg S; Jenkins, Mark A; Thibodeau, Stephen N; Schumacher, Fredrick R; Lindor, Noralane M; Kolonel, Laurence N; Hopper, John L; Gong, Jian; Seminara, Daniela; Pflugeisen, Bethann M; Ulrich, Cornelia M; Qu, Conghui; Duggan, David; Cotterchio, Michelle; Campbell, Peter T; Carlson, Christopher S; Newcomb, Polly A; Giovannucci, Edward; Hsu, Li; Chan, Andrew T; Peters, Ulrike; Chang-Claude, Jenny (Nature Publishing Group, 2016)
      Background: Menopausal hormone therapy (MHT) use has been consistently associated with a decreased risk of colorectal cancer (CRC) in women. Our aim was to use a genome-wide gene–environment interaction analysis to identify ...

    • Cystathionine β-Synthase Inhibition Is a Potential Therapeutic Approach to Treatment of Ischemic Injury 

      Chan, Su Jing; Chai, Chou; Lim, Tze Wei; Yamamoto, Mie; Lo, Eng H; Lai, Mitchell Kim Peng; Wong, Peter Tsun Hon (SAGE Publications, 2015)
      Hydrogen sulfide (H2S) has been reported to exacerbate stroke outcome in experimental models. Cystathionine β-synthase (CBS) has been implicated as the predominant H2S-producing enzyme in central nervous system. When SH-SY5Y ...

    • Cystatin C and Creatinine in an HIV Cohort: the Nutrition for Healthy Living Study 

      Jones, Clara Y.; Jones, Camille A.; Wilson, Ira B.; Knox, Tamsin A.; Levey, Andrew S.; Spiegelman, Donna; Gorbach, Sherwood L.; Lente, Frederick Van; Stevens, Lesley A. (Elsevier, 2008)
      Background: Human immunodeficiency virus (HIV)-infected persons have an increased risk of chronic kidney disease (CKD). Serum creatinine level may underestimate the prevalence of CKD in subjects with decreased lean body ...

    • Cystatin C deficiency in human atherosclerosis and aortic aneurysms 

      Shi, Guo-Ping; Sukhova, Galina K.; Grubb, Anders; Ducharme, Anique; Rhode, Luis H.; Lee, Richard Theodore; Ridker, Paul M.; Libby, Peter; Chapman, Harold A. (American Society for Clinical Investigation, 1999)
      The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves breakdown of the elastic laminae. Elastolytic cysteine proteases, including cathepsins S and K, are overexpressed at sites of arterial elastin ...

    • Cystatin C Deficiency Promotes Epidermal Dysplasia in K14-HPV16 Transgenic Mice 

      Yu, Weifang; Liu, Jian; Shi, Michael A.; Wang, Jianan; Xiang, Meixiang; Kitamoto, Shiro; Wang, Bing; Sukhova, Galina K.; Murphy, George F.; Orasanu, Gabriela; Grubb, Anders; Shi, Guo-Ping; Câmara, Niels Olsen Saraiva (Public Library of Science, 2010)
      Background: Cysteine protease cathepsins are important in extracellular matrix protein degradation, cell apoptosis, and angiogenesis. Mice lacking cathepsins are protected from tumor progression in several animal models, ...

    • Cystatin C is Downregulated in Prostate Cancer and Modulates Invasion of Prostate Cancer Cells via MAPK/Erk and Androgen Receptor Pathways 

      Wegiel, Barbara; Jiborn, Thomas; Abrahamson, Magnus; Helczynski, Leszek; Otterbein, Leo E.; Persson, Jenny Liao; Bjartell, Anders (Public Library of Science, 2009)
      Cystatin C is believed to prevent tumor progression by inhibiting the activities of a family of lysosomal cysteine proteases. However, little is known about the precise mechanism of cystatin C function in prostate cancer. ...

    • Cystatin C-Based Renal Function Changes After Antiretroviral Initiation: A Substudy of a Randomized Trial 

      Gupta, Samir K.; Kitch, Douglas; Tierney, Camlin; Daar, Eric S.; Sax, Paul E.; Melbourne, Kathleen; Ha, Belinda; McComsey, Grace A. (Oxford University Press, 2014)
      Background. The effects of antiretrovirals on cystatin C-based renal function estimates are unknown. Methods. We analyzed changes in renal function using creatinine and cystatin C-based estimating equations in 269 patients ...

    • Cysteinyl Leukotriene Antagonism Inhibits Bronchoconstriction in Respose to Hypertonic Saline Inhalation in Asthma 

      Kazani, S; Sadeh, J; Bunga, S; Wechsler, ME; Israel, Elliot
      Background: In asthma, cysteinyl leukotrienes (CysLTs) play varying roles in the bronchomotor response to multiple provocative stimuli. The contribution of CysLTs on the airway's response to hypertonic saline (HS) inhalation ...

    • Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules 

      Neves, Josiane S.; Radke, Amy L.; Weller, Peter Fahey (Elsevier BV, 2010)
      Background—Cysteinyl leukotrienes are recognized to act via receptors (CysLTRs) expressed on cell surface plasma membranes. Agents that block CysLT1R, are therapeutics for allergic disorders. Eosinophils contain multiple ...

    • Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts 

      Kanaoka, Yoshihide; Boyce, Joshua A. (The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease, 2014)
      Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification ...

    • Cystic Fibrosis Related Bone Disease 

      Putman, Melissa (2015-05-20)
      Over the past several decades, life expectancy for patients with cystic fibrosis (CF) has increased significantly. As patients live longer, other nonpulmonary co-morbidities related to CF have become increasingly prevalent, ...

    • Cystic Papillary Pattern in Pancreatic Ductal Adenocarcinoma 

      Kelly, Paul J.; Shinagare, Shweta; Sainani, Nisha I.; Hong, Xiao; Ferrone, Cristina Rosa; Yilmaz, Omer Hidir; Fernandez-Del Castillo, Carlos F.; Lauwers, Gregory Y.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2012)
      INTRODUCTION: The prototypic pancreatic ductal adenocarcinoma shows small-caliber glands that are placed within an exuberant desmoplastic stromal reaction. A number of histologic patterns have been described, and the ...

    • Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection 

      Cserti-Gazdewich, Christine M; Dhabangi, Aggrey; Musoke, Charles; Ssewanyana, Isaac; Ddungu, Henry; Nakiboneka-Ssenabulya, Deborah; Nabukeera-Barungi, Nicolette; Mpimbaza, Arthur; Dzik, Walter Henry (Blackwell Publishing Ltd, 2012)
      As a leading cause of childhood mortality worldwide, selection pressure by Plasmodium falciparum continues to shape the human genome. Severe disturbances within the microcirculation result from the adhesion of infected ...

    • Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. 

      Shao, Zhuo; Fu, Zhong Jie; Stahl, A.; Joyal, Julie Anne; Hatton, Colin Paul; Juan, A.; Hurst, C.; Evans, L.; Cui, Z.; Pei, D.; Gong, Yan; Xu, D.; Tian, K.; Bogardus, H.; Edin, M. L.; Lih, F.; Sapieha, P.; Chen, Jing; Panigrahy, Dipak; Hellstrom, A.; Zeldin, D. C.; Smith, Lois Elaine Hodgson (Ovid Technologies (Wolters Kluwer Health), 2014)
      OBJECTIVE: Regulation of angiogenesis is critical for many diseases. Specifically, pathological retinal neovascularization, a major cause of blindness, is suppressed with dietary ω3-long-chain polyunsaturated fatty acids ...

    • Cytochrome P450-Derived Eicosanoids: The Neglected Pathway in Cancer 

      Panigrahy, Dipak; Kaipainen, Arja; Greene, Emily R.; Huang, Sui (Springer US, 2010)
      Endogenously produced lipid autacoids are locally acting small molecule mediators that play a central role in the regulation of inflammation and tissue homeostasis. A well-studied group of autacoids are the products of ...

    • Cytokine and Antioxidant Regulation in the Intestine of the Gray Mouse Lemur (Microcebus murinus) During Torpor 

      Tessier, Shannon N.; Katzenback, Barbara A.; Pifferi, Fabien; Perret, Martine; Storey, Kenneth B. (Elsevier, 2015)
      During food shortages, the gray mouse lemur (Microcebus murinus) of Madagascar experiences daily torpor thereby reducing energy expenditures. The present study aimed to understand the impacts of torpor on the immune system ...