Browsing by Title
Now showing items 53925-53944 of 56955
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U-manifolds
(Elsevier, 1997)We use non-perturbative U-duality symmetries of type II strings to construct new vacuum solutions. In some ways this generalizes the F-theory vacuum constructions. We find the possibilities of new vacuum constructions are ... -
U-Shaped Association between Plasma Manganese Levels and Type 2 Diabetes
(National Institute of Environmental Health Sciences, 2016)Background: Manganese is both an essential element and a known toxicant, and it plays important roles in many mechanisms in relation to type 2 diabetes (T2D). However, epidemiological studies of this relationship are rare. ... -
U-SPECT-BioFluo: an integrated radionuclide, bioluminescence, and fluorescence imaging platform
(Springer, 2014)Background: In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated ... -
U.S. county-level characteristics to inform equitable COVID-19 response
(Cold Spring Harbor Laboratory, 2020-04-11)Background: The spread of Coronavirus Disease 2019 (COVID-19) across the United States confirms that not all Americans are equally at risk of infection, severe disease, or mortality. A range of intersecting biological, ... -
The U.S. CURES Act would mandate OA
(Scholarly Publishing and Academic Resources Coalition, 2006) -
U.S. Daily Temperatures: The Meaning of Extremes in the Context of Nonnormality
(American Meteorological Society, 2014)Variations in extreme daily temperatures are explored in relation to changes in seasonal mean temperature using 1218 high-quality U.S. temperature stations spanning 1900–2012. Extreme temperatures are amplified (or damped) ... -
U.S. Drinking Water Challenges in the Twenty-First Century
(National Institute of Environmental Health Sciences, 2002)The access of almost all 270 million U.S. residents to reliable, safe drinking water distinguishes the United States in the twentieth century from that of the nineteenth century. The United States is a relatively water-abundant ... -
U.S. Drug Manufacturers Beware: Application of the PRC Antibribery Law to Drug Marketing and Promotional Practices in China
(2002)China’s ongoing economic growth and tremendous market potentials have presented many opportunities for American pharmaceutical manufacturers. According to a report issued by the Pharmaceutical Research ... -
U.S. Government Secrecy and the Current Crackdown on Leaks
(Shorenstein Center on Media, Politics and Public Policy, 2003)In the never-ending sparring match between the government and the news media, no subject produces more friction than the practice of leaking classified information. Government officials—at least those who don’t leak—denounce ... -
U.S. Governors and the Medicaid Expansion — No Quick Resolution in Sight
(New England Journal of Medicine (NEJM/MMS), 2013) -
U.S. High-Skilled Immigration, Innovation, and Entrepreneurship: Empirical Approaches and Evidence
(2014-01-13)High-skilled immigrants are a very important component of U.S. innovation and entrepreneurship. Immigrants account for roughly a quarter of U.S. workers in these fields, and they have a similar contribution in terms of ... -
U.S. Monetary Policy in an Integrating World: 1960 to 2000
(Federal Reserve Bank of Boston, 2001)This article examines the impact of global developments on the practice of U.S. monetary policy, broadly defined to include regulatory and lender-of-last-resort functions as well as open market, discount, and intervention ... -
The U.S. physician workforce: serious questions raised, answers needed
(American College of Physicians, 2004) -
U.S. Physicians’ Views on Financing Options to Expand Health Insurance Coverage: A National Survey
(Springer, 2009)Background: Physician opinion can influence the prospects for health care reform, yet there are few recent data on physician views on reform proposals or access to medical care in the United States. Objective: To assess ... -
The U.S.-Russia Joint Threat Assessment of Nuclear Terrorism
(Belfer Center for Science and International Affairs, Harvard Kennedy School, and Institute for U.S. and Canadian Studies., 2011)Nuclear terrorism is a real and urgent threat. Given the potentially catastrophic consequences, even a small probability of terrorists getting and detonating a nuclear bomb is enough to justify urgent action to reduce the ... -
U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish
(Oxford University Press, 2015)Mutations in FUS cause amyotrophic lateral sclerosis (ALS), but the molecular pathways leading to neurodegeneration remain obscure. We previously found that U1 snRNP is the most abundant FUS interactor. Here, we report ... -
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
(National Academy of Sciences, 2007)The Brca1 A complex contains Brca1/Bard1, Abraxas, Rap80, and Brcc36; however, with the exception of the Brca1-Abraxas interaction, how the A complex is assembled is not known. The A complex is localized to sites of DNA ... -
Ubi Cogito, Ibi Sum: Paranoid Epistemology in Russian Fiction 1833-1907
(2013-08-12)This dissertation addresses two questions fundamental to Russian nineteenth-century intellectual history: 1) Why does literature about paranoid psychosis figure so centrally in the nineteenth-century canon? and 2) How did ... -
UBIAD1 Mutation Alters a Mitochondrial Prenyltransferase to Cause Schnyder Corneal Dystrophy
(Public Library of Science, 2010)Background: Mutations in a novel gene, UBIAD1, were recently found to cause the autosomal dominant eye disease Schnyder corneal dystrophy (SCD). SCD is characterized by an abnormal deposition of cholesterol and phospholipids ... -
Ubiquitin Accumulation in Autophagy-Deficient Mice is Dependent on the Nrf2-Mediated Stress Response Pathway: A Potential Role for Protein Aggregation in Autophagic Substrate Selection
(Rockefeller University Press, 2010)Genetic ablation of autophagy in mice leads to liver and brain degeneration accompanied by the appearance of ubiquitin (Ub) inclusions, which has been considered to support the hypothesis that ubiquitination serves as a ...