Browsing by FAS Department "Biophysics"
Now showing items 21-25 of 25
-
Single-Molecule Studies of Bacterial Chromosome Organization and Segregation
(2017-01-04)The bacterial chromosome is dramatically compacted into a subcellular structure called nucleoid. Simultaneously, it must be organized to allow the protein machinery for essential cellular processes to gain access to the ... -
Targeted Measurement and Manipulation of Hydrogen Peroxide in the Cardiovascular System
(2017-08-24)Hydrogen peroxide (H2O2) is a reactive oxygen species (ROS) with a diverse range of reported roles in both normal physiology and disease. While H2O2 and other ROS have long been reported to be drivers of acute and chronic ... -
Three-Dimensional Chromosome Organization in Eukaryotes
(2015-05-20)The study of chromosome, and genome, organization is a both an ongoing challenge, and one with a long history. Following the advent of high-throughput sequencing and genomic technologies, much research has focused on the ... -
Towards a Systematic Approach for Characterizing Regulatory Variation
(2015-11-03)A growing body of evidence suggests that genetic variants that alter gene expression are responsible for many phenotypic differences across individuals, particularly for the risk of developing common diseases. However, the ... -
Understanding Cellular Specialization Through Functional Genomics
(2015-09-18)The human body is composed of hundreds of specialized cell types, each fulfilling distinct functions that are together essential for normal tissue homeostasis. This thesis is aimed at identifying genes that contribute to ...