Browsing by FAS Department "Biology, Molecular and Cellular"
Now showing items 21-40 of 66
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Flagellar Biosynthesis in E.coli Is Regulated by a Cascade of Stochastic Pulses
(2017-01-20)Genetically identical populations of bacteria can exhibit significant phenotypic heterogeneity even in the absence of environmental variations. In bacteria such as Bacillus and Salmonella, flagellar motility has been found ... -
Fluorescence Imaging of Virus-Host Cell Interaction and Super-Resolution Imaging of Neuronal Cytoskeleton
(2015-11-10)To study biological molecules, pathways and processes, fluorescence microscope has become an indispensable tool in modern biology. The major advantages of using fluorescence microscope include its ability to achieve ... -
Genetic Basis of Natural Variation in Cellular Decision Making in Wild Yeasts
(2018-05-15)In nature, microbes often need to decide which of many potential nutrients to consume. This decision-making process is complex, involving both intracellular constraints and the organism’s perception of the environment. ... -
Genetic Regulation of Germ Layer Formation in Vertebrate Development
(2017-09-08)Early embryogenesis is a profoundly important time during which morphological rearrangements pattern the growing embryo. Research throughout animals has demonstrated that both the morphological changes and the underlying ... -
Genetics and Regulation of Bacterial Biofilms
(2015-03-24)Bacterial biofilm formation, the construction of dense, protective, multicellular communities, is a widely conserved behavior. In some bacteria, such as the Gram-positive model organism Bacillus subtilis, the genetics ... -
Genomes of Small RNA Viruses: Amendments, Discoveries, and Characterizations
(2018-05-10)RNA viruses make up a disproportionate amount of emerging human diseases, largely contribute to agriculture, and are recognized for their important roles in shaping the evolution of life. Metagenomics datasets have emphasized ... -
Genomic Imprinting in the Brain: the persistent influences from Mom and Dad
(2015-05-20)Most mammalian genes are equally expressed from the two inherited parental alleles. However, a puzzling subgroup known as imprinted genes are preferentially expressed from either the maternally- or paternally-inherited ... -
Improving Stem Cell-Based Therapy and Developing a Novel Gene Therapy Approach for Treating Duchenne Muscular Dystrophy (DMD)
(2016-01-26)Genetic mutations in muscle structural genes can compromise myofiber integrity, causing repeated muscle damage that ultimately exhausts muscle regenerative capacity and results in devastating degenerative conditions such ... -
In Vivo Reprogramming of Neuronal Identity and Local Connectivity in the Neocortex
(2017-01-20)Neurons of the mammalian central nervous system are widely considered as canonical examples of terminally differentiated cells. Using excitatory projection neurons (PNs) of the mouse neocortex as a model, this dissertation ... -
Integrating Regulatory Information in Eukaryotic Transcription
(2018-08-17)Transcriptional regulation is a key determinant of cell differentiation during development. Changes in where and when a gene is expressed can lead to phenotypic variation among individuals, and ultimately to phenotypic ... -
Integrative Approaches to Synthetic Biology in Human Cells
(2017-01-26)Synthetic biology endeavors to develop systems and processes to aid in the rapid, predictable, and reproducible design of biological systems not only for use as research tools and also but to address unmet needs in industry ... -
Intergenerational Transmission of Non-Germline RNAs in Caenorhabditis Elegans
(2018-05-13)In the model organism Caenorhabditis elegans, double-stranded RNA (dsRNA) capable of silencing genes can be introduced anywhere in the animal and will subsequently travel throughout the body and enter most cells, including ... -
Investigating Extracellular DNA Release in Staphylococcus Aureus Biofilm Formation
(2017-01-25)Staphylococcus aureus is a leading cause of nosocomial infections in the United States, and isolates of this pathogen are capable of forming biofilms through different mechanisms. Biofilm formation reduces susceptibility ... -
Investigation of the Gene Expression Dynamics of Early Mammalian Germ Layer Differentiation
(2017-11-02)The mechanisms regulating the timing of developmental processes are poorly understood. To systematically investigate the timing of development and its underlying mechanisms, the dynamics of development must first be ... -
Investigation of the Mechanism That Powers DNA Translocation During Bacterial Natural Transformation
(2016-07-26)If deoxyribonucleic acids are the building blocks of life, perhaps the proteins that move, shape, and assemble nucleic acids should be called architects. These proteins come in every size and shape and have vastly different ... -
Mesendoderm Patterning by Vg1/Nodal Heterodimers
(2018-05-14)One of the key processes during development is the induction of the mesoderm and endoderm (mesendoderm), which generates the precursors of the heart, liver, gut, pancreas, kidney and other internal organs. Nodal, a member ... -
Metabolic Regulation of Hematopoietic Stem Cell Production and Maintenance
(2016-06-20)Metabolic disorders are a leading cause of morbidity and mortality, with gestational diabetes impacting embryogenesis. Intriguingly, children born to diabetic mothers have a higher risk of developing childhood leukemia, ... -
The Molecular Determinants of Cranial Skeletal Development and Evolution
(2015-10-01)The vertebrate head and face, one of the defining features of vertebrates, is an evolutionary novelty that enabled the major radiation of Vertebrata. The emergence of the multipotent neural crest cells, often mentioned as ... -
Morphological, Physiological and Molecular Classification of Mouse Retinal Ganglion Cells
(2016-01-15)Visual information is conveyed from the retina to the brain through axons of retinal ganglion cells (RGCs). There are >20 different subtypes of RGCs, each of which detects specific features. Classification of RGC subtypes ... -
Motion Processing in the Larval Zebrafish Tectum
(2015-05-14)Larval zebrafish are highly visual animals that display a diverse repertoire of visually guided behaviors. Five days after their birth, they start tracking and hunting moving prey, a behavior that likely requires underlying ...