Browsing by Title
Now showing items 28072-28091 of 57604
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Irregularity and Locking to the Seasonal Cycle in an ENSO Prediction Model as Explained by the Quasi-Periodicity Route to Chaos
(American Meteorological Society, 1995)The behavior of the Cane-Zebiak ENSO prediction model is analyzed as a function of model parameters measuring the strength of coupling between the model ocean and atmosphere and the amplitude of the back-ground seasonal ... -
The Irrelevance of the Broccoli Argument Against the Insurance Mandate
(Massachusetts Medical Society, 2011) -
Irreversibility
(Oxford University Press, 2010)The concept of "irreversibility" plays a large role in many domains, including public health, medical practice, and environmental protection. Indeed, the concept is explicit in some statements of the Precautionary Principle. ... -
Irreversible and Catastrophic
(Cornell Law Review, 2006)As many treaties and statutes emphasize, some risks are distinctive in the sense that they are potentially irreversible or catastrophic; for such risks, it is sensible to take extra precautions. When a harm is irreversible, ... -
Irreversible and Catastrophic: Global Warming, Terrorism, and Other Problems
(Pace University School of Law, 2006)As many treaties and statutes emphasize, some risks are distinctive in the sense that they are potentially irreversible or catastrophic; for such risks, it is sensible to take extra precautions. When a harm is irreversible, ... -
The Irreversible Loss of a Decomposition Pathway Marks the Single Origin of an Ectomycorrhizal Symbiosis
(Public Library of Science, 2012)Microbial symbioses have evolved repeatedly across the tree of life, but the genetic changes underlying transitions to symbiosis are largely unknown, especially for eukaryotic microbial symbionts. We used the genus Amanita, ... -
IRS-2 Deficiency Impairs NMDA Receptor-Dependent Long-term Potentiation
(Oxford University Press, 2011)The beneficial effects of insulin and insulin-like growth factor I on cognition have been documented in humans and animal models. Conversely, obesity, hyperinsulinemia, and diabetes increase the risk for neurodegenerative ... -
IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation
(Nature Publishing Group, 2016)Endoplasmic reticulum (ER) stress is among several pathological features that underlie β-cell failure in the development of type 1 and type 2 diabetes. Adaptor proteins in the insulin/insulin-like-growth factor-1 signaling ... -
IRS1 Genotype Modulates Metabolic Syndrome Reversion in Response to 2-Year Weight-Loss Diet Intervention: The POUNDS LOST trial
(American Diabetes Association, 2013)OBJECTIVE Genetic variants near IRS1 are associated with features of the metabolic syndrome (MetS). We examined whether genetic variants near IRS1 might modulate the effects of diets varying in fat content on the MetS ... -
Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis★
(Elsevier, 2013)Insulin receptor substrates (Irs1, 2, 3 and Irs4) mediate the actions of insulin/IGF1 signaling. They have similar structure, but distinctly regulate development, growth, and metabolic homeostasis. Irs2 contributes to ... -
IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer
(Blackwell Publishing Ltd, 2013)Copy number alterations are frequently found in colorectal cancer (CRC), and recurrent gains or losses are likely to correspond to regions harbouring genes that promote or impede carcinogenesis respectively. Gain of ... -
Is "Economic Power" a Useful and Operational Concept?
(Weatherhead Center for International Affairs, Harvard University, 2004)With the end of the Cold War, and until 9/11/01, many academic and journalistic pundits averred that military power was no longer of great importance, that the future lay with economic power. The claim was made that the ... -
Is (S)He Presidential? The Changing Scripts of Political Leadership, 1995-2020
(2021-09-09)This dissertation investigates how political strategists craft narratives of political leadership for presidential candidates in the digital age. Based on 110 in-depth interviews with high-profile political operatives in ... -
Is a New and General Theory of Molecular Systematics Emerging?
(Wiley-Blackwell, 2009)The advent and maturation of algorithms for estimating species trees-phylogenetic trees that allow gene tree heterogeneity and whose tips represent lineages, populations and species, as opposed to genes-represent an exciting ... -
Is a Nuclear Deal with Iran Possible? An Analytical Framework for the Iran Nuclear Negotiations
(2012)Varied diplomatic approaches by multiple negotiators over several years have failed to conclude a nuclear deal with Iran. Mutual hostility, misperception, and flawed diplomacy may be responsible. Yet, more fundamentally, ... -
Is a VC Partnership Greater Than the Sum of Its Partners?
(Wiley-Blackwell, 2015)This paper investigates whether individual venture capitalists have repeatable investment skill and to what extent their skill is impacted by the VC firm where they work. We examine a unique dataset that tracks the performance ... -
Is aggressive treatment of smoldering myeloma the path to curing myeloma?
(American Society of Hematology, 2023-07-27)Smoldering multiple myeloma (SMM) is an asymptomatic condition that precedes newly diagnosed multiple myeloma (ND MM) and is present in ~1 of 200 individuals (0.5%) aged >40 years.1 The optimal management of patients with ... -
Is America Becoming More Exceptional?: How Public Policy Corporatized Social Citizenship
(Palgrave/Macmillan, 2002) -
Is American health care uniquely inefficient?
(American Economic Association, 2008)The U.S. health system has been described as the most competitive, heterogeneous, inefficient, fragmented, and advanced system of care in the world. In this paper, we consider two questions: First, is the U.S. healthcare ... -
Is an Ounce of Prevention Worth an Ounce of Cure? Explaining the Decline in Cardiovascular Mortality, 1964-2010
(2011)Mortality from coronary heart disease in the United States has fallen 60% from its peak. Cardiologists and epidemiologists have debated whether this decline reflects risk factor control or the power of medical therapeutics. ...