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Now showing items 20630-20649 of 57604
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A Functional Genomics Approach to Viral-Host Interactions for HIV
(BioMed Central, 2010) -
Functional Genomics Approaches to Identify and Characterize Oncogenic Signaling
(2013-10-15)Oncogenes drive cancer by hijacking normal cellular functions involved in proliferation and survival. Suppression of the driving oncogene is highly effective for promoting tumor regression, a phenomenon termed "oncogenic ... -
Functional Genomics at the EHEC-Intestinal Interface: Mechanisms of Pathogenicity and the Host Response
(2021-01-20)Enterohemorrhagic Escherichia coli (EHEC) is a human foodborne pathogen that infects the colon, leading to hemorrhagic colitis and the potentially fatal hemolytic uremic syndrome. This dissertation aims to address the ... -
Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst
(Nature Pub. Group, 2015)The phagocyte oxidative burst, mediated by Nox2 NADPH oxidase-derived reactive oxygen species, confers host defense against a broad spectrum of bacterial and fungal pathogens. Loss-of-function mutations that impair function ... -
Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans
(2013)Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. Here, by integrating transcriptional analysis and functional ... -
Functional Genomics of the Rapidly Replicating Bacterium Vibrio Natriegens by CRISPRi
(Springer Science and Business Media LLC, 2019-04-08)The fast growing Gram-negative bacterium Vibrio natriegens is an attractive microbial system for molecular biology and biotechnology due to its remarkable short generation time1,2 and metabolic prowess3,4. However, efforts ... -
Functional Haplotypes of the hTERT Gene, Leukocyte Telomere Length Shortening, and the Risk of Peripheral Arterial Disease
(Public Library of Science, 2012)Background: The development of peripheral arterial disease (PAD) is heterogeneous even in the presence of similar risk factors. Our aim was to determine whether inter-individual differences in leukocyte telomere length ... -
Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
(MyJove Corporation, 2015)There is currently a severe shortage of liver grafts available for transplantation. Novel organ preservation techniques are needed to expand the pool of donor livers. Machine perfusion of donor liver grafts is an alternative ... -
Functional Identification of Api5 as a Suppressor of E2F-Dependent Apoptosis In Vivo
(Public Library of Science, 2006)Retinoblastoma protein and E2-promoter binding factor (E2F) family members are important regulators of G1-S phase progression. Deregulated E2F also sensitizes cells to apoptosis, but this aspect of E2F function is poorly ... -
Functional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene and Creates a Fusion Transcript
(Public Library of Science, 2015)Despite many years of study into inversions, very little is known about their functional consequences, especially in humans. A common hypothesis is that the selective value of inversions stems in part from their effects ... -
The functional impact of subsyndromal depressive symptoms in bipolar disorder: Data from STEP-BD
(Elsevier BV, 2009)Background This report describes baseline characteristics and functional outcomes of subjects who have prospectively observed subsyndromal symptoms after a major depressive episode (MDE). Methods All subjects were ... -
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons
(2014)Psychiatric disorders have clear heritable risk. Several large-scale genome-wide association studies have revealed a strong association between susceptibility for psychiatric disorders, including bipolar disease, schizophrenia, ... -
Functional Interactions in the Hematopoietic Stem Cell Niche: Stem Cells, Endothelial Cells, and Macrophages
(2018-05-15)The hematopoietic stem cell (HSC) niche is a specialized environment that supports the maintenance and regulation of hematopoietic stem and progenitor cells (HSPCs). The various cell types that comprise the niche and the ... -
Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells
(Impact Journals LLC, 2016)The xCT light chain of the cystine/glutamate transporter (system XC−) is of importance for the survival of triple-negative breast cancer (TNBC) cells. The MUC1-C transmembrane oncoprotein is aberrantly overexpressed in ... -
The functional interplay between TNPO3, CPSF6 and HIV-1 CA
(2014-10-21)Lentiviruses can infect postmitotic cells, indicative of a role for the nucleocytoplasmic transport machinery. Genome-wide RNA interference screens identified transportin 3 (TNPO3) that may regulate human immunodeficiency ... -
Functional kinomics establishes a critical node of volume-sensitive cation-Cl− cotransporter regulation in the mammalian brain
(Nature Publishing Group, 2016)Cell volume homeostasis requires the dynamically regulated transport of ions across the plasmalemma. While the ensemble of ion transport proteins involved in cell volume regulation is well established, the molecular ... -
Functional limitations and workdays lost associated with chronic rhinosinusitis and allergic rhinitis
(OceanSide Publications, Inc., 2012)Background: Chronic rhinosinusitis (CRS) and allergic rhinitis are associated with functional limitations, but these impacts are not known on a population basis. Our objective was to epidemiologically determine functional ... -
Functional Limitations, Medication Support, and Responses to Drug Costs among Medicare Beneficiaries
(Public Library of Science, 2015)Objective: Standard Medicare Part D prescription drug benefits include substantial and complex cost-sharing. Many beneficiaries also have functional limitations that could affect self-care capabilities, including managing ... -
A Functional Magnetic Resonance Imaging Study of Auditory Mismatch in Schizophrenia
(American Psychiatric Publishing, 2001)Objective: Previous research has noted functional and structural temporal lobe abnormalities in schizophrenia that relate to symptoms such as auditory hallucinations and thought disorder. The goal of the study was to ... -
Functional Materials Grown from Engineered Bacteria
(2021-07-12)Nature has produced living materials with wonderful properties, including the ability to self-regenerate, to sense and respond to a changing environment, and to harvest energy from the sun. Inspired by this, researchers ...