Browsing by Title

Now showing items 20610-20629 of 57568

    • 'Functional Follies' for an Urban Slum 

      Akakpo, Kofi (2021-01-20)
      “The challenge for Africa is no less than the restoration of its intellectual freedom and a capacity to create—without which no sovereignty is conceivable.”1 The general attitude toward architecture on the African ...

    • Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia 

      Lips, E S; Cornelisse, L N; Toonen, R F; Min, J.L.; Hultman, C M; Holmans, P A; O'Donovan, M C; Purcell, Shaun; Smit, A B; Verhage, M; Sullivan, P.F.; Visscher, P M; Posthuma, D (Nature Publishing Group, 2012)
      Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ∼1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated ...

    • Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome 

      Roosing, Susanne; Hofree, Matan; Kim, Sehyun; Scott, Eric; Copeland, Brett; Romani, Marta; Silhavy, Jennifer L; Rosti, Rasim O; Schroth, Jana; Mazza, Tommaso; Miccinilli, Elide; Zaki, Maha S; Swoboda, Kathryn J; Milisa-Drautz, Joanne; Dobyns, William B; Mikati, Mohamed A; İncecik, Faruk; Azam, Matloob; Borgatti, Renato; Romaniello, Romina; Boustany, Rose-Mary; Clericuzio, Carol L; D'Arrigo, Stefano; Strømme, Petter; Boltshauser, Eugen; Stanzial, Franco; Mirabelli-Badenier, Marisol; Moroni, Isabella; Bertini, Enrico; Emma, Francesco; Steinlin, Maja; Hildebrandt, Friedhelm; Johnson, Colin A; Freilinger, Michael; Vaux, Keith K; Gabriel, Stacey B; Aza-Blanc, Pedro; Heynen-Genel, Susanne; Ideker, Trey; Dynlacht, Brian D; Lee, Ji Eun; Valente, Enza Maria; Kim, Joon; Gleeson, Joseph G (eLife Sciences Publications, Ltd, 2015)
      Defective primary ciliogenesis or cilium stability forms the basis of human ciliopathies, including Joubert syndrome (JS), with defective cerebellar vermis development. We performed a high-content genome-wide small interfering ...

    • Functional Genomic Analysis of C. elegans Molting 

      Frand, Alison R; Russel, Sascha Elle; Ruvkun, Gary B. (Public Library of Science, 2005)
      Although the molting cycle is a hallmark of insects and nematodes, neither the endocrine control of molting via size, stage, and nutritional inputs nor the enzymatic mechanism for synthesis and release of the exoskeleton ...

    • A Functional Genomic Analysis of Cell Morphology Using RNA Interference 

      Kiger, AA; Baum, B; Jones, MR; Coulson, A; Echeverri, C; Perrimon, Norbert; Jones, S (BioMed Central, 2003)
      Background: The diversity of metazoan cell shapes is influenced by the dynamic cytoskeletal network. With the advent of RNA-interference (RNAi) technology, it is now possible to screen systematically for genes controlling ...

    • Functional genomic dissection of human brain development, degeneration, and dysfunction in pediatric neurogenetic disorders 

      Lai, Jenny (2023-09-13)
      Human disease genetics has implicated hundreds of genes in brain development, maintenance, and function. Experimentally tractable animal models and culture systems have contributed greatly to understanding the function of ...

    • Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma 

      Hettmer, Simone; Schinzel, Anna C; Tchessalova, Daria; Schneider, Michaela; Parker, Christina L; Bronson, Roderick T; Richards, Nigel GJ; Hahn, William C; Wagers, Amy J (eLife Sciences Publications, Ltd, 2015)
      Current therapies for sarcomas are often inadequate. This study sought to identify actionable gene targets by selective targeting of the molecular networks that support sarcoma cell proliferation. Silencing of asparagine ...

    • A Functional Genomic Yeast Screen to Identify Pathogenic Bacterial Proteins 

      Slagowski, Naomi L; Kramer, Roger W; Morrison, Monica F; LaBaer, Joshua; Lesser, Cammie (Public Library of Science, 2008)
      Many bacterial pathogens promote infection and cause disease by directly injecting into host cells proteins that manipulate eukaryotic cellular processes. Identification of these translocated proteins is essential to ...

    • A Functional Genomics Approach to Viral-Host Interactions for HIV 

      Elledge, Stephen J. (BioMed Central, 2010)

    • Functional Genomics Approaches to Identify and Characterize Oncogenic Signaling 

      Shao, Diane Donghui (2013-10-15)
      Oncogenes drive cancer by hijacking normal cellular functions involved in proliferation and survival. Suppression of the driving oncogene is highly effective for promoting tumor regression, a phenomenon termed "oncogenic ...

    • Functional Genomics at the EHEC-Intestinal Interface: Mechanisms of Pathogenicity and the Host Response 

      Warr, Alyson R (2021-01-20)
      Enterohemorrhagic Escherichia coli (EHEC) is a human foodborne pathogen that infects the colon, leading to hemorrhagic colitis and the potentially fatal hemolytic uremic syndrome. This dissertation aims to address the ...

    • Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst 

      Graham, Daniel B.; Becker, Christine E.; Doan, Aivi; Goel, Gautam; Villablanca, Eduardo J.; Knights, Dan; Mok, Amanda; Ng, Aylwin C.Y.; Doench, John G.; Root, David E.; Clish, Clary B.; Xavier, Ramnik J. (Nature Pub. Group, 2015)
      The phagocyte oxidative burst, mediated by Nox2 NADPH oxidase-derived reactive oxygen species, confers host defense against a broad spectrum of bacterial and fungal pathogens. Loss-of-function mutations that impair function ...

    • Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans 

      Smeekens, Sanne P.; Ng, Aylwin; Kumar, Vinod; Johnson, Melissa D.; Plantinga, Theo S.; van Diemen, Cleo; Arts, Peer; Verwiel, Eugéne T.P.; Gresnigt, Mark S.; Fransen, Karin; van Sommeren, Suzanne; Oosting, Marije; Cheng, Shih-Chin; Joosten, Leo A.B.; Hoischen, Alexander; Kullberg, Bart-Jan; Scott, William K.; Perfect, John R.; van der Meer, Jos W.M.; Wijmenga, Cisca; Netea, Mihai G.; Xavier, Ramnik J. (2013)
      Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. Here, by integrating transcriptional analysis and functional ...

    • Functional Genomics of the Rapidly Replicating Bacterium Vibrio Natriegens by CRISPRi 

      Ostrov, Nili; Lee, Henry; Wong, Brandon; Gold, Michaela; Khalil, Ahmad; Church, George (Springer Science and Business Media LLC, 2019-04-08)
      The fast growing Gram-negative bacterium Vibrio natriegens is an attractive microbial system for molecular biology and biotechnology due to its remarkable short generation time1,2 and metabolic prowess3,4. However, efforts ...

    • Functional Haplotypes of the hTERT Gene, Leukocyte Telomere Length Shortening, and the Risk of Peripheral Arterial Disease 

      Zhang, Weili; Yang, Xiaomin; Fan, Jingyao; Mi, Xuenan; Wang, Jizheng; Zhang, Channa; Hui, Rutai; Chen, Yu; Hu, Frank B. (Public Library of Science, 2012)
      Background: The development of peripheral arterial disease (PAD) is heterogeneous even in the presence of similar risk factors. Our aim was to determine whether inter-individual differences in leukocyte telomere length ...

    • Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion 

      Bruinsma, Bote G.; Avruch, James H.; Weeder, Pepijn D.; Sridharan, Gautham V.; Uygun, Basak E.; Karimian, Negin G.; Porte, Robert J.; Markmann, James F.; Yeh, Heidi; Uygun, Korkut (MyJove Corporation, 2015)
      There is currently a severe shortage of liver grafts available for transplantation. Novel organ preservation techniques are needed to expand the pool of donor livers. Machine perfusion of donor liver grafts is an alternative ...

    • Functional Identification of Api5 as a Suppressor of E2F-Dependent Apoptosis In Vivo 

      Morris, Erick J; Michaud, William A; Ji, Jun-Yuan; Moon, Nam-Sung; Rocco, James W; Dyson, Nicholas John (Public Library of Science, 2006)
      Retinoblastoma protein and E2-promoter binding factor (E2F) family members are important regulators of G1-S phase progression. Deregulated E2F also sensitizes cells to apoptosis, but this aspect of E2F function is poorly ...

    • Functional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene and Creates a Fusion Transcript 

      Puig, Marta; Castellano, David; Pantano, Lorena; Giner-Delgado, Carla; Izquierdo, David; Gayà-Vidal, Magdalena; Lucas-Lledó, José Ignacio; Esko, Tõnu; Terao, Chikashi; Matsuda, Fumihiko; Cáceres, Mario (Public Library of Science, 2015)
      Despite many years of study into inversions, very little is known about their functional consequences, especially in humans. A common hypothesis is that the selective value of inversions stems in part from their effects ...

    • The functional impact of subsyndromal depressive symptoms in bipolar disorder: Data from STEP-BD 

      Marangell, Lauren B.; Dennehy, Ellen B.; Miyahara, Sachiko; Wisniewski, Stephen R.; Bauer, Mark S; Rapaport, Mark Hyman; Allen, Michael H. (Elsevier BV, 2009)
      Background This report describes baseline characteristics and functional outcomes of subjects who have prospectively observed subsyndromal symptoms after a major depressive episode (MDE). Methods All subjects were ...

    • Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons 

      Yoshimizu, Takao; Pan, Jen Q.; Mungenast, Alison E.; Madison, Jon M.; Su, Susan; Ketterman, Josh; Ongur, Dost; McPhie, Donna; Cohen, Bruce; Perlis, Roy; Tsai, Li-Huei (2014)
      Psychiatric disorders have clear heritable risk. Several large-scale genome-wide association studies have revealed a strong association between susceptibility for psychiatric disorders, including bipolar disease, schizophrenia, ...