Browsing by Title
Now showing items 20610-20629 of 57604
-
Functional Development and Plasticity of Parvalbumin Cells in Visual Cortex: Role of Thalamocortical Input
(2013-03-15)Unlike principal excitatory neurons, cortical interneurons comprise a diverse group of distinct subtypes. They can be classified by their morphology, molecular content, developmental origins, electrophysiological properties ... -
Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
(Nature Publishing Group, 2016)Inner ear sensory epithelia contain mechanosensitive hair cells that transmit information to the brain through innervation with bipolar neurons. Mammalian hair cells do not regenerate and are limited in number. Here we ... -
Functional Differences in Engineered Myocardium from Embryonic Stem Cell-Derived versus Neonatal Cardiomyocytes
(Elsevier, 2013)Summary Stem cell-derived cardiomyocytes represent unique tools for cell- and tissue-based regenerative therapies, drug discovery and safety, and studies of fundamental heart-failure mechanisms. However, the degree to which ... -
A Functional Difficulty and Functional Pain Instrument for Hip and Knee Osteoarthritis
(BioMed Central, 2009)Introduction: The objectives of this study were to develop a functional outcome instrument for hip and knee osteoarthritis research (OA-FUNCTION-CAT) using item response theory (IRT) and computer adaptive test (CAT) methods ... -
Functional diversity among sensory receptors in a Drosophila olfactory circuit
(Proceedings of the National Academy of Sciences, 2013)The ability of an animal to detect, discriminate, and respond to odors depends on the function of its olfactory receptor neurons (ORNs), which in turn depends ultimately on odorant receptors. To understand the diverse ... -
Functional Effects of the TMEM43 Ser358Leu Mutation in the Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy
(BioMed Central, 2012)Background: The Ser358Leu mutation in TMEM43, encoding an inner nuclear membrane protein, has been implicated in arrhythmogenic right ventricular cardiomyopathy (ARVC). The pathogenetic mechanisms of this mutation are ... -
Functional Enhancers at the Gene-Poor 8q24 Cancer-Linked Locus
(Public Library of Science, 2009)Multiple discrete regions at 8q24 were recently shown to contain alleles that predispose to many cancers including prostate, breast, and colon. These regions are far from any annotated gene and their biological activities ... -
Functional ENTPD1 Polymorphisms in African Americans With Diabetes and End-Stage Renal Disease
(American Diabetes Association, 2008)Objective: The vascular ectonucleotidase ENTPD1 protects against renal injury and modulates glucose homeostasis in mouse models. We sought to determine whether human variation in ENTPD1 influences predisposition to diabetes ... -
Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation
(The Company of Biologists, 2013)Embryonic stem (ES) cells hold great promise with respect to their potential to be differentiated into desired cell types. Of interest are organs derived from the definitive endoderm, such as the pancreas and liver, and ... -
Functional Evolution of cis-Regulatory Modules at a Homeotic Gene in Drosophila
(Public Library of Science, 2009)It is a long-held belief in evolutionary biology that the rate of molecular evolution for a given DNA sequence is inversely related to the level of functional constraint. This belief holds true for the protein-coding ... -
Functional Evolution of the Trace Amine Associated Receptors in Mammals and the Loss of TAAR1 in Dogs
(BioMed Central, 2010)Background: The trace amine associated receptor family is a diverse array of GPCRs that arose before the first vertebrates walked on land. Trace amine associated receptor 1 (TAAR1) is a wide spectrum aminergic receptor ... -
Functional extracellular eosinophil granules: Novel implications in eosinophil immunobiology
(Elsevier BV, 2009)Human eosinophils contain within their cytoplasmic granules multiple preformed proteins, including over three dozen cytokines with nominal Th1, Th2 and immunoregulatory capabilities, and four distinctive cationic proteins. ... -
'Functional Follies' for an Urban Slum
(2021-01-20)“The challenge for Africa is no less than the restoration of its intellectual freedom and a capacity to create—without which no sovereignty is conceivable.”1 The general attitude toward architecture on the African ... -
Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia
(Nature Publishing Group, 2012)Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ∼1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated ... -
Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome
(eLife Sciences Publications, Ltd, 2015)Defective primary ciliogenesis or cilium stability forms the basis of human ciliopathies, including Joubert syndrome (JS), with defective cerebellar vermis development. We performed a high-content genome-wide small interfering ... -
Functional Genomic Analysis of C. elegans Molting
(Public Library of Science, 2005)Although the molting cycle is a hallmark of insects and nematodes, neither the endocrine control of molting via size, stage, and nutritional inputs nor the enzymatic mechanism for synthesis and release of the exoskeleton ... -
A Functional Genomic Analysis of Cell Morphology Using RNA Interference
(BioMed Central, 2003)Background: The diversity of metazoan cell shapes is influenced by the dynamic cytoskeletal network. With the advent of RNA-interference (RNAi) technology, it is now possible to screen systematically for genes controlling ... -
Functional genomic dissection of human brain development, degeneration, and dysfunction in pediatric neurogenetic disorders
(2023-09-13)Human disease genetics has implicated hundreds of genes in brain development, maintenance, and function. Experimentally tractable animal models and culture systems have contributed greatly to understanding the function of ... -
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma
(eLife Sciences Publications, Ltd, 2015)Current therapies for sarcomas are often inadequate. This study sought to identify actionable gene targets by selective targeting of the molecular networks that support sarcoma cell proliferation. Silencing of asparagine ... -
A Functional Genomic Yeast Screen to Identify Pathogenic Bacterial Proteins
(Public Library of Science, 2008)Many bacterial pathogens promote infection and cause disease by directly injecting into host cells proteins that manipulate eukaryotic cellular processes. Identification of these translocated proteins is essential to ...