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Now showing items 20590-20609 of 57604
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Functional Characterization of Netrin-1 and Its Role in CNS-PNS Boundary Maintenance in the Developing Vertebrate Brainstem
(2018-05-01)Netrin-1 (Ntn1) has represented the archetype of diffusible guidance cues since its discovery in the 1990s. It is often depicted in a gradient emanating from the floor plate of the embryonic neural tube, through which it ... -
Functional Characterization of Potential New Agents for Cancer Immunotherapy
(2018-05-16)PD-1/PD-L1 checkpoint blockade has demonstrated promise in a variety of malignancies. The blockade of T cell inhibitory molecules PD-1 and PD-L1 can rejuvenate T cells and improve tumor cell killing. However, the overall ... -
Functional Characterization of the Human Hippocampal Long Axis Using Within-Individual Precision Neuroimaging
(2023-08-22)This dissertation describes my efforts towards a precise network-informed functional characterization of the human hippocampal long axis, made possible by advances in within-individual precision human neuroimaging. In the ... -
Functional circuit architecture underlying parental behaviour
(Springer Science and Business Media LLC, 2018-04)Parenting is essential for the survival and wellbeing of mammalian offspring but we lack a circuit-level understanding of how distinct components of this behaviour are orchestrated. Here we investigate how Galanin-expressing ... -
Functional classification analysis of somatically mutated genes in human breast and colorectal cancers
(Elsevier BV, 2008)A recent study published by Sjoblom and colleagues performed comprehensive sequencing of 13,023 human genes and identified mutations in genes specific to breast and colorectal tumors, providing insight into organ-specific ... -
Functional Connectivity Density Mapping of Depressive Symptoms and Loneliness in Non-Demented Elderly Male
(Frontiers Media S.A., 2016)Background: Depression and loneliness are prevalent and highly correlated phenomena among the elderly and influence both physical and mental health. Brain functional connectivity changes associated with depressive symptoms ... -
Functional Connectivity in Multiple Cortical Networks Is Associated with Performance Across Cognitive Domains in Older Adults
(Mary Ann Liebert, Inc., 2015)Abstract Intrinsic functional connectivity MRI has become a widely used tool for measuring integrity in large-scale cortical networks. This study examined multiple cortical networks using Template-Based Rotation (TBR), a ... -
Functional Connectivity in the First Year of Life in Infants at Risk for Autism Spectrum Disorder: An EEG Study
(Public Library of Science, 2014)In the field of autism research, recent work has been devoted to studying both behavioral and neural markers that may aide in early identification of autism spectrum disorder (ASD). These studies have often tested infants ... -
Functional connectivity in the first year of life in infants at-risk for autism: a preliminary near-infrared spectroscopy study
(Frontiers Media S.A., 2013)Background: Autism spectrum disorder (ASD) has been called a “developmental disconnection syndrome,” however the majority of the research examining connectivity in ASD has been conducted exclusively with older children and ... -
Functional connectivity of visual cortex in the blind follows retinotopic organization principles
(Oxford University Press, 2015)Is visual input during critical periods of development crucial for the emergence of the fundamental topographical mapping of the visual cortex? And would this structure be retained throughout life-long blindness or would ... -
Functional connectivity of visual cortex in the blind follows retinotopic organization principles
(Oxford University Press, 2015)Is visual input during critical periods of development crucial for the emergence of the fundamental topographical mapping of the visual cortex? And would this structure be retained throughout life-long blindness or would ... -
Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients
(Frontiers Media S.A., 2016)Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious ... -
The Functional Consequences of Cortical Circuit Abnormalities on Gamma Oscillations in Schizophrenia: Insights from Computational Modeling
(Frontiers Research Foundation, 2009)Schizophrenia is characterized by cortical circuit abnormalities, which might be reflected in γ-frequency (30–100 Hz) oscillations in the electroencephalogram. Here we used a computational model of cortical circuitry to ... -
Functional Contribution of PDGFRbeta+ Cells in Angiogenesis and Metastatic Breast Cancer
(2013-10-18)Tumor stroma is known to affect tumor growth and metastasis. Inhibiting PDGF signaling, with the goal of depleting PDGFRβ+ stromal cells, is a putative therapeutic approach in this context. PDGFRβ is widely ... -
Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral Sclerosis
(Public Library of Science, 2013)Endoplasmic reticulum (ER) stress represents an early pathological event in amyotrophic lateral sclerosis (ALS). ATF4 is a key ER stress transcription factor that plays a role in both adaptation to stress and the activation ... -
Functional Contributions of Carbohydrate on AIDS Virus Glycoprotein
(YJBM, 2010)Envelope glycoprotein spikes on the surface of the human immunodeficiency virus (HIV) are used by the virus to bind to cellular receptors to gain entry into target cells. As such, the envelope spikes are the targets of ... -
Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear
(The Rockefeller University Press, 2013)The hyperpolarization-activated current, Ih, is carried by members of the Hcn channel family and contributes to resting potential and firing properties in excitable cells of various systems, including the auditory system. ... -
Functional Copy-Number Alterations in Cancer
(Public Library of Science, 2008)Understanding the molecular basis of cancer requires characterization of its genetic defects. DNA microarray technologies can provide detailed raw data about chromosomal aberrations in tumor samples. Computational analysis ... -
Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62
(eLife Sciences Publications, Ltd, 2016)SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening ...