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Now showing items 20570-20589 of 57604
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Functional and morphological analysis of the subretinal injection of human retinal progenitor cells under Cyclosporin A treatment
(Molecular Vision, 2014)Purpose The purpose of this study is to evaluate the functional and morphological changes in subretinal xenografts of human retinal progenitor cells (hRPCs) in B6 mice treated with Cyclosporin A (CsA; 210 mg/l in drinking ... -
Functional and structural brain correlates of risk for major depression in children with familial depression
(Elsevier, 2015)Despite growing evidence for atypical amygdala function and structure in major depression, it remains uncertain as to whether these brain differences reflect the clinical state of depression or neurobiological traits that ... -
Functional and Structural Deficits in Brain Regions Subserving Face Perception in Schizophrenia
(American Psychiatric Publishing, 2006)Objective: Schizophrenia impairs many cognitive functions, including face perception. Veridical face perception is critical for social interaction, including distinguishing friend from foe and familiar from unfamiliar ... -
Functional and structural differences in the hippocampus associated with memory deficits in adult survivors of acute lymphoblastic leukemia
(Wiley-Blackwell, 2013)Background Radiation and chemotherapy targeted to the central nervous system (CNS) can cause cognitive impairment, including impaired memory. These memory impairments may be referable to damage to hippocampal structures ... -
Functional and Structural Methods with Mixed Measurement Error and Misclassification in Covariates
(Taylor & Francis, 2015)Covariate measurement imprecision or errors arise frequently in many areas. It is well known that ignoring such errors can substantially degrade the quality of inference or even yield erroneous results. Although in practice ... -
Functional Antagonism between CCAAT/Enhancer Binding Protein-α and Peroxisome Proliferator-activated Receptor-γ on the Leptin Promoter
(American Society for Biochemistry and Molecular Biology, 1997)The ob gene product, leptin, is a major hormonal regulator of appetite and fat cell mass, Recent work has suggested that the antidiabetic agents, the thiazolidinediones (TZ), which are also high affinity ligands of peroxisome ... -
Functional Architecture of Low-Frequency Variants Highlights Strength of Negative Selection Across Coding and Non-Coding Annotations
(Springer Science and Business Media LLC, 2018-11)Common variant heritability has been widely reported to be concentrated in variants within cell-type-specific non-coding functional annotations, but little is known about low-frequency variant functional architectures. We ... -
Functional Assessment of Human Variants in Noncoding Regulatory Sequences
(2023-06-01)The advancement of next-generation sequencing technology has facilitated the identification of deleterious coding variants that underlie various human diseases. Now, emerging evidence indicates that noncoding variants also ... -
Functional assessment of the cell entry pathway of Lymphocytic choriomeningitis virus
(2022-03-17)Lymphocytic choriomeningitis virus (LCMV) is the prototypic member of the mammarenaviruses, the majority of which are rodent-borne, zoonotic viruses primarily associated with a particular rodent host. LCMV has been utilized ... -
Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
(Nature Publishing Group, 2012)Insulin-expressing cells that have been differentiated from human pluripotent stem cells in vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell maturation in mice was studied to find genetic ... -
Functional Brain Imaging of Young, Nondemented, and Demented Older Adults
(Massachusetts Institute of Technology Press, 2000)Brain imaging based on functional MRI (fMRI) provides a powerful tool for characterizing age-related changes in functional anatomy. However, between-population comparisons confront potential differences in measurement ... -
Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy
(Elsevier BV, 2015)Brown adipose tissue (BAT) has well recognized thermogenic properties mediated by uncoupling protein 1 (UCP1); more recently, BAT has been demonstrated to modulate cardiovascular risk factors. To investigate whether BAT ... -
Functional characterization of a bacteriophage-encoded inhibitor of Staphylococcus aureus transcription
(2013-10-18)Functional characterization of a bacteriophage-encoded inhibitor of Staphylococcus aureus transcription -
Functional characterization of Alzheimer’s disease genetic variants in microglia
(Springer Science and Business Media LLC, 2023-09-21) -
Functional Characterization of Bacteria Isolated from Ancient Arctic Soil Exposes Diverse Resistance Mechanisms to Modern Antibiotics
(Public Library of Science, 2013-07-02)Using functional metagenomics to study the resistomes of bacterial communities isolated from different layers of the Canadian high Arctic permafrost, we show that microbial communities harbored diverse resistance mechanisms ... -
Functional characterization of genetic alterations in cancer
(2016-05-18)The comprehensive identification of genetic alterations is critical to understanding the pathophysiology of cancer. Recent advances in sequencing technology have enabled the detailed description of cancer genomes. However, ... -
Functional characterization of genetic variation with in silico predictions of cell-type-specific regulatory elements
(2020-09-10)Genome-wide association studies (GWAS) have implicated thousands of complex trait-variant associations, an estimated 90% of which reside in the noncoding genome. While noncoding variants generally have poorly understood ... -
Functional Characterization of HLA-G+ Regulatory T Cells in HIV-1 Infection
(Public Library of Science, 2013)Regulatory T cells represent a specialized subpopulation of T lymphocytes that may modulate spontaneous HIV-1 disease progression by suppressing immune activation or inhibiting antiviral T cell immune responses. While the ... -
Functional Characterization of JMJD2A, a Histone Deacetylase- and Retinoblastoma-binding Protein
(American Society for Biochemistry and Molecular Biology, 2005) -
Functional Characterization of mSWI/SNF Complexes using Perturb-seq
(2021-07-12)Mammalian SWI/SNF (mSWI/SNF or BAF) complexes are multi-subunit chromatin remodeling machines that use the power derived from ATP hydrolysis to mobilize nucleosomes and facilitate chromatin accessibility. mSWI/SNF complexes ...