Browsing by Title
Now showing items 20570-20589 of 57568
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Functional characterization of a bacteriophage-encoded inhibitor of Staphylococcus aureus transcription
(2013-10-18)Functional characterization of a bacteriophage-encoded inhibitor of Staphylococcus aureus transcription -
Functional characterization of Alzheimer’s disease genetic variants in microglia
(Springer Science and Business Media LLC, 2023-09-21) -
Functional Characterization of Bacteria Isolated from Ancient Arctic Soil Exposes Diverse Resistance Mechanisms to Modern Antibiotics
(Public Library of Science, 2013-07-02)Using functional metagenomics to study the resistomes of bacterial communities isolated from different layers of the Canadian high Arctic permafrost, we show that microbial communities harbored diverse resistance mechanisms ... -
Functional characterization of genetic alterations in cancer
(2016-05-18)The comprehensive identification of genetic alterations is critical to understanding the pathophysiology of cancer. Recent advances in sequencing technology have enabled the detailed description of cancer genomes. However, ... -
Functional characterization of genetic variation with in silico predictions of cell-type-specific regulatory elements
(2020-09-10)Genome-wide association studies (GWAS) have implicated thousands of complex trait-variant associations, an estimated 90% of which reside in the noncoding genome. While noncoding variants generally have poorly understood ... -
Functional Characterization of HLA-G+ Regulatory T Cells in HIV-1 Infection
(Public Library of Science, 2013)Regulatory T cells represent a specialized subpopulation of T lymphocytes that may modulate spontaneous HIV-1 disease progression by suppressing immune activation or inhibiting antiviral T cell immune responses. While the ... -
Functional Characterization of JMJD2A, a Histone Deacetylase- and Retinoblastoma-binding Protein
(American Society for Biochemistry and Molecular Biology, 2005) -
Functional Characterization of mSWI/SNF Complexes using Perturb-seq
(2021-07-12)Mammalian SWI/SNF (mSWI/SNF or BAF) complexes are multi-subunit chromatin remodeling machines that use the power derived from ATP hydrolysis to mobilize nucleosomes and facilitate chromatin accessibility. mSWI/SNF complexes ... -
Functional Characterization of Netrin-1 and Its Role in CNS-PNS Boundary Maintenance in the Developing Vertebrate Brainstem
(2018-05-01)Netrin-1 (Ntn1) has represented the archetype of diffusible guidance cues since its discovery in the 1990s. It is often depicted in a gradient emanating from the floor plate of the embryonic neural tube, through which it ... -
Functional Characterization of Potential New Agents for Cancer Immunotherapy
(2018-05-16)PD-1/PD-L1 checkpoint blockade has demonstrated promise in a variety of malignancies. The blockade of T cell inhibitory molecules PD-1 and PD-L1 can rejuvenate T cells and improve tumor cell killing. However, the overall ... -
Functional Characterization of the Human Hippocampal Long Axis Using Within-Individual Precision Neuroimaging
(2023-08-22)This dissertation describes my efforts towards a precise network-informed functional characterization of the human hippocampal long axis, made possible by advances in within-individual precision human neuroimaging. In the ... -
Functional circuit architecture underlying parental behaviour
(Springer Science and Business Media LLC, 2018-04)Parenting is essential for the survival and wellbeing of mammalian offspring but we lack a circuit-level understanding of how distinct components of this behaviour are orchestrated. Here we investigate how Galanin-expressing ... -
Functional classification analysis of somatically mutated genes in human breast and colorectal cancers
(Elsevier BV, 2008)A recent study published by Sjoblom and colleagues performed comprehensive sequencing of 13,023 human genes and identified mutations in genes specific to breast and colorectal tumors, providing insight into organ-specific ... -
Functional Connectivity Density Mapping of Depressive Symptoms and Loneliness in Non-Demented Elderly Male
(Frontiers Media S.A., 2016)Background: Depression and loneliness are prevalent and highly correlated phenomena among the elderly and influence both physical and mental health. Brain functional connectivity changes associated with depressive symptoms ... -
Functional Connectivity in Multiple Cortical Networks Is Associated with Performance Across Cognitive Domains in Older Adults
(Mary Ann Liebert, Inc., 2015)Abstract Intrinsic functional connectivity MRI has become a widely used tool for measuring integrity in large-scale cortical networks. This study examined multiple cortical networks using Template-Based Rotation (TBR), a ... -
Functional Connectivity in the First Year of Life in Infants at Risk for Autism Spectrum Disorder: An EEG Study
(Public Library of Science, 2014)In the field of autism research, recent work has been devoted to studying both behavioral and neural markers that may aide in early identification of autism spectrum disorder (ASD). These studies have often tested infants ... -
Functional connectivity in the first year of life in infants at-risk for autism: a preliminary near-infrared spectroscopy study
(Frontiers Media S.A., 2013)Background: Autism spectrum disorder (ASD) has been called a “developmental disconnection syndrome,” however the majority of the research examining connectivity in ASD has been conducted exclusively with older children and ... -
Functional connectivity of visual cortex in the blind follows retinotopic organization principles
(Oxford University Press, 2015)Is visual input during critical periods of development crucial for the emergence of the fundamental topographical mapping of the visual cortex? And would this structure be retained throughout life-long blindness or would ... -
Functional connectivity of visual cortex in the blind follows retinotopic organization principles
(Oxford University Press, 2015)Is visual input during critical periods of development crucial for the emergence of the fundamental topographical mapping of the visual cortex? And would this structure be retained throughout life-long blindness or would ...