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Now showing items 20550-20569 of 57604
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The function of the Heg-CCM pathway in zebrafish heart development
(2013-10-08)The Heart of glass-Cerebral Cavernous Malformation (Heg-CCM) pathway is essential for heart development in zebrafish and mouse. In zebrafish, mutants for the Heg-CCM genes ccm1, ccm2, and heg exhibit an extreme dilation ... -
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains
(Rockefeller University Press, 2003)A member of the family of ATPases associated with diverse cellular activities, called p97 in mammals and Cdc48 in yeast, associates with the cofactor Ufd1-Np14 to move polyubiquitinated polypeptides from the endoplasmic ... -
Function-on-Function Regression with Public Health Applications
(2014-06-06)Medical research currently involves the collection of large and complex data. One such type of data is functional data where the unit of measurement is a curve measured over a grid. Functional data comes in a variety of ... -
Function-Specific Serotonergic Neurons in the Control of Breathing and Body Temperature
(2015-10-05)The control of respiration and body temperature involves neural circuits within the brainstem modulated by the neurotransmitter serotonin (5HT), though it is unclear precisely which serotonergic neurons are critical to ... -
Functional adaptive landscapes predict terrestrial capacity at the origin of limbs
(Springer Science and Business Media LLC, 2020-11-25)The acquisition of terrestrial, limb-based locomotion during tetrapod evolution has remained a subject of debate for more than a century1,2. Our current understanding of the locomotor transition from water-to-land is largely ... -
Functional Analysis of a Novel Potassium Channel (KCNA1) Mutation in Hereditary Mokymia
(Springer-Verlag, 2007)Myokymia is characterized by spontaneous, involuntary muscle fiber group contraction visible as vermiform movement of the overlying skin. Myokymia with episodic ataxia is a rare, autosomal dominant trait caused by mutations ... -
Functional analysis of Miro GTPase domains in the mitochondrial motor adaptor complex
(2020-12-18)Mitochondria are actively transported in all somatic cells where their motility is essential for proper cellular function. Mitochondrial transport relies on microtubules and a highly regulated motor/adaptor complex that ... -
Functional analysis of multiple activities associated with the herpes simplex virus-1 DNA polymerase
(2018-05-11)Of the DNA replication proteins required for herpes simplex virus-1 (HSV-1) viral replication, the catalytic subunit of the DNA polymerase (Pol) has been the most extensively studied, both as a model for Family B polymerases ... -
Functional Analysis of Notch Signaling during Vertebrate Retinal Development
(2013-02-25)The process of cell fate determination, which establishes the vastly diverse set of neural cell types found in the central nervous system, remains poorly understood. During retinal development, multipotent retinal progenitor ... -
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
(National Academy of Sciences, 2012)We assessed somatic alleles of six receptor tyrosine kinase genes mutated in lung adenocarcinoma for oncogenic activity. Five of these genes failed to score in transformation assays; however, novel recurring extracellular ... -
Functional Analysis of Sirtuin Genes in Multiple Plasmodium falciparum Strains
(Public Library of Science, 2015)Plasmodium falciparum, the causative agent of severe human malaria, employs antigenic variation to avoid host immunity. Antigenic variation is achieved by transcriptional switching amongst polymorphic var genes, enforced ... -
Functional Analysis of the Accessory Protein TapA in Bacillus subtilis Amyloid Fiber Assembly
(American Society for Microbiology, 2014)Bacillus subtilis biofilm formation relies on the assembly of a fibrous scaffold formed by the protein TasA. TasA polymerizes into highly stable fibers with biochemical and morphological features of functional amyloids. ... -
Functional Analysis of VopF Activity Required for Colonization in Vibrio cholerae
(American Society of Microbiology, 2010)Vibrio cholerae, a Gram-negative facultative pathogen, is the etiologic agent for the diarrheal disease cholera. We previously characterized a clinical isolate, AM-19226, that translocates a type III secretion system (T3SS) ... -
Functional Anatomy of Recognition of Chinese Multi-Character Words: Convergent Evidence from Effects of Transposable Nonwords, Lexicality, and Word Frequency
(Public Library of Science, 2016)This fMRI study aimed to identify the neural mechanisms underlying the recognition of Chinese multi-character words by partialling out the confounding effect of reaction time (RT). For this purpose, a special type of ... -
Functional Anatomy of the Vertebrates. An Evolutionary Perspective. (Book Review)
(University of Chicago Press, 1988) -
Functional and architectural complexity within and between muscles: regional variation and intermuscular force transmission
(The Royal Society, 2011)Over the past 30 years, studies of single muscles have revealed complex patterns of regional variation in muscle architecture, activation, strain and force. In addition, muscles are often functionally integrated with other ... -
Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist
(Company of Biologists, 1998)Wnts are highly conserved developmental regulators that mediate inductive signaling between neighboring cells and participate in the determination of embryonic axes. Frizzled proteins constitute a large family of putative ... -
Functional and diffusion tensor magnetic resonance imaging of the sheep brain
(BioMed Central, 2015)Background: An ovine model can cast great insight in translational neuroscientific research due to its large brain volume and distinct regional neuroanatomical structures. The present study examined the applicability of ... -
Functional and Genomic Analyses of Klebsiella Pneumoniae Population Dynamics in the Gastrointestinal Tract
(2015-12-17)The gastrointestinal tract is home to trillions of bacteria that interact with each other and with the host’s mucosal immune system. Obligate and facultative anaerobes thrive in the small and large intestine. While many ... -
Functional and genomic analysis of MEF2 transcription factors in neural development
(2014-10-21)Development of the central nervous system requires the precise coordination of intrinsic genetic programs to instruct cell fate, synaptic connectivity and function. The MEF2 family of transcription factors (TFs) plays many ...