Browsing by Author "Israel, Elliot"

Now showing items 1-20 of 46

    • Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma 

      Sheehan, William; Mauger, David T.; Paul, Ian M.; Moy, James N.; Boehmer, Susan J.; Szefler, Stanley J.; Fitzpatrick, Anne M.; Jackson, Daniel J.; Bacharier, Leonard B.; Cabana, Michael D.; Covar, Ronina; Holguin, Fernando; Lemanske, Robert F.; Martinez, Fernando D.; Pongracic, Jacqueline A.; Beigelman, Avraham; Baxi, Sachin; Benson, Mindy; Blake, Kathryn; Chmiel, James F.; Daines, Cori L.; Daines, Michael O.; Gaffin, Jonathan; Gentile, Deborah A.; Gower, W. Adam; Israel, Elliot; Kumar, Harsha V.; Lang, Jason E.; Lazarus, Stephen C.; Lima, John J.; Ly, Ngoc; Marbin, Jyothi; Morgan, Wayne J.; Myers, Ross E.; Olin, J. Tod; Peters, Stephen P.; Raissy, Hengameh H.; Robison, Rachel G.; Ross, Kristie; Sorkness, Christine A.; Thyne, Shannon M.; Wechsler, Michael E.; Phipatanakul, Wanda (Massachusetts Medical Society, 2016-08-18)
      BACKGROUND Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with ...

    • Active Albuterol or Placebo, Sham Acupuncture, or No Intervention in Asthma 

      Wechsler, Michael E.; Kelley, John; Boyd, Ingrid O.E.; Dutile, Stefanie; Marigowda, Gautham; Kirsch, Irving; Israel, Elliot; Kaptchuk, Ted (Massachusetts Medical Society, 2011-07-14)
      BACKGROUND In prospective experimental studies in patients with asthma, it is difficult to determine whether responses to placebo differ from the natural course of physiological changes that occur without any intervention. ...

    • Adam8 Limits the Development of Allergic Airway Inflammation in Mice 

      Knolle, M. D.; Nakajima, T.; Hergrueter, A.; Gupta, K.; Polverino, Francesca; Craig, V; Fyfe, S. E.; Zahid, M.; Permaul, Perdita; Cernadas, Manuela; Montano, Giancarlo Vengco; Tesfaigzi, Y.; Sholl, Lynette Marie; Kobzik, Lester; Israel, Elliot; Owen, Caroline Ann (The American Association of Immunologists, 2013)
      To determine whether a disintegrin and a metalloproteinase-8 (Adam8) regulates allergic airway inflammation (AAI) and airway hyper-responsiveness (AHR), we compared AAI and AHR in wild type (WT) versus Adam8−/− mice in ...

    • Add-on LABA in a separate inhaler as asthma step-up therapy versus increased dose of ICS or ICS/LABA combination inhaler 

      Price, David B.; Colice, Gene; Israel, Elliot; Roche, Nicolas; Postma, Dirkje S.; Guilbert, Theresa W.; van Aalderen, Willem M.C.; Grigg, Jonathan; Hillyer, Elizabeth V.; Thomas, Victoria; Martin, Richard J. (European Respiratory Society, 2016)
      Asthma management guidelines recommend adding a long-acting β2-agonist (LABA) or increasing the dose of inhaled corticosteroid (ICS) as step-up therapy for patients with uncontrolled asthma on ICS monotherapy. However, it ...

    • Airway Lipoxin A4 Generation and Lipoxin A4 Receptor Expression Are Decreased in Severe Asthma 

      Planaguma, Anna; Kazani, Shamsah; Marigowda, Gautham; Haworth, Oliver; Mariani, Thomas J.; Israel, Elliot; Bleecker, Eugene R.; Curran-Everett, Douglas; Erzurum, Serpil C.; Calhoun, William J.; Castro, Mario; Chung, Kian Fan; Gaston, Benjamin M.; Jarjour, Nizar N.; Busse, William W.; Wenzel, Sally E.; Levy, Bruce (American Thoracic Society, 2008-09-15)
      Rationale: Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A4 (LXA4) is an arachidonic acid–derived mediator that serves as an agonist for resolution of ...

    • Asthma Is More Severe in Older Adults 

      Zein, Joe G.; Dweik, Raed A.; Comhair, Suzy A.; Bleecker, Eugene R.; Moore, Wendy C.; Peters, Stephen P.; Busse, William W.; Jarjour, Nizar N.; Calhoun, William J.; Castro, Mario; Chung, K. Fan; Fitzpatrick, Anne; Israel, Elliot; Teague, W. Gerald; Wenzel, Sally E.; Love, Thomas E.; Gaston, Benjamin M.; Erzurum, Serpil C. (Public Library of Science, 2015)
      Background: Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration. Methods: This is a ...

    • Characterization of Factors Associated With Systemic Corticosteroid Use in Severe Asthma: Data From the Severe Asthma Research Program 

      Wysocki, Kenneth; Park, Seo Young; Bleecker, Eugene R.; Busse, William; Castro, Mario; Chung, Kian Fan; Gaston, Benjamin M.; Erzurum, Serpil C.; Israel, Elliot; Teague, W. Gerald; Moore, Charity G.; Wenzel, Sally E. (Elsevier BV, 2014-03)
      Background Exhaled nitric oxide (FeNO) associates with asthma and eosinophilic inflammation. However, relationships between nitric oxide synthases, arginase, FeNO, asthma severity and inflammation remain poorly ...

    • Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma 

      Riley, Craig M.; Wenzel, Sally E.; Castro, Mario; Erzurum, Serpil C.; Chung, Kian Fan; Fitzpatrick, Anne M.; Gaston, Benjamin; Israel, Elliot; Moore, Wendy C.; Bleecker, Eugene R.; Calhoun, William J.; Jarjour, Nizar N.; Busse, William W.; Peters, Stephen P.; Teague, W. Gerald; Sorkness, Ronald; Holguin, Fernando (Public Library of Science (PLoS), 2015-12-30)
      Introduction FEF25-75 is one of the standard results provided in spirometry reports; however, in adult asthmatics there is limited information on how this physiological measure relates to clinical or biological outcomes ...

    • Clinical Predictors of Health-Related Quality of Life Depend on Asthma Severity 

      Moy, ML; Juniper, EF; Dubé, L; Drazen, JM; Israel, Elliot; Weiss, Scott
      The National Asthma Education and Prevention Program guide-lines define asthma severity before treatment by lung functionand symptoms. It has been assumed, but not demonstrated, thatimprovement in these measures would ...

    • Comparing the effectiveness of small-particle versus large-particle inhaled corticosteroid in COPD 

      Postma, Dirkje S; Roche, Nicolas; Colice, Gene; Israel, Elliot; Martin, Richard J; van Aalderen, Willem MC; Grigg, Jonathan; Burden, Anne; Hillyer, Elizabeth V; von Ziegenweidt, Julie; Gopalan, Gokul; Price, David (Dove Medical Press, 2014)
      Purpose Small airway changes and dysfunction contribute importantly to airway obstruction in chronic obstructive pulmonary disease (COPD), which is currently treated with inhaled corticosteroids (ICS) and long-acting ...

    • Corticosteroid Suppression of Lipoxin A\(_4\) and Leukotriene B\(_4\) from Alveolar Macrophages in Severe Asthma 

      Bhavsar, Pankaj K; Levy, Bruce David; Hew, Mark J; Pfeffer, Michael A; Kazani, Shamsah; Israel, Elliot; Chung, Kian Fan (BioMed Central, 2010)
      Background: An imbalance in the generation of pro-inflammatory leukotrienes, and counter-regulatory lipoxins is present in severe asthma. We measured leukotriene B\(_4\) (LTB\(_4\)), and lipoxin A\(_4\) (LXA\(_4\)) production ...

    • Cost-effectiveness of initiating extrafine- or standard size-particle inhaled corticosteroid for asthma in two health-care systems: a retrospective matched cohort study 

      Martin, Richard J; Price, David; Roche, Nicolas; Israel, Elliot; van Aalderen, Willem MC; Grigg, Jonathan; Postma, Dirkje S; Guilbert, Theresa W; Hillyer, Elizabeth V; Burden, Anne; von Ziegenweidt, Julie; Colice, Gene (Nature Publishing Group, 2014)
      Background: Real-life studies are needed to determine the cost-effectiveness of asthma therapies in clinical practice. Aim: To compare the cost-effectiveness of extrafine-particle inhaled corticosteroid (ICS) with standard ...

    • Cysteinyl Leukotriene Antagonism Inhibits Bronchoconstriction in Respose to Hypertonic Saline Inhalation in Asthma 

      Kazani, S; Sadeh, J; Bunga, S; Wechsler, ME; Israel, Elliot
      Background: In asthma, cysteinyl leukotrienes (CysLTs) play varying roles in the bronchomotor response to multiple provocative stimuli. The contribution of CysLTs on the airway's response to hypertonic saline (HS) inhalation ...

    • Diminished Lipoxin Biosynthesis in Severe Asthma 

      Levy, BD; Bonnans, C; Silverman, ES; Palmer, LJ; Marigowda, G; Israel, Elliot
      Rationale and Objectives: Severe asthma is characterized by increased airway inflammation that persists despite therapy with corticosteroids. It is not, however, merely an exaggeration of the eosinophilic inflammation that ...

    • Effect of Rare Variants in ADRB2 on Risk of Severe Exacerbations and Symptom Control During Longacting β Agonist Treatment in a Multiethnic Asthma Population: A Genetic Study 

      Ortega, Victor E.; Hawkins, Gregory A.; Moore, Wendy C.; Hastie, Annette T.; Ampleford, Elizabeth J.; Busse, William W.; Castro, Mario; Chardon, Domingo; Erzurum, Serpil C.; Israel, Elliot; Montealegre, Federico; Wenzel, Sally E.; Peters, Stephen P.; Meyers, Deborah A.; Bleecker, Eugene R. (Elsevier BV, 2014-03)
      Background Severe adverse life-threatening events associated with long-acting beta agonists (LABA) use have caused the FDA to review LABA safety which has resulted in a boxed warning and a mandatory LABA safety study in ...

    • Effect of β2-Adrenergic Receptor Polymorphism on Response to Longacting β2 Agonist in Asthma (LARGE Trial): A Genotype-Stratified, Randomised, Placebo-Controlled, Crossover Trial 

      Wechsler, Michael; Kunselman, Susan J.; Chinchilli, Vernon M.; Bleecker, Eugene R.; Boushey, Homer A.; Calhoun, William J.; Ameredes, Bill T.; Castro, Mario; Craig, Timothy J.; Denlinger, Loren; Fahy, John V.; Jarjour, Nizar; Kazani, Shamsah; Kim, Sophia; Kraft, Monica; Lazarus, Stephen C.; Lemanske, Robert F.; Markezich, Amy; Martin, Richard J.; Permaul, Perdita; Peters, Stephen P.; Ramsdell, Joe; Sorkness, Christine A.; Sutherland, E. Rand; Szefler, Stanley J.; Walter, Michael J.; Wasserman, Stephen I.; Israel, Elliot (Elsevier BV, 2009-11-21)
      Background Combined long-acting β2-agonist and inhaled corticosteroid (LABA/ICS) therapy improves outcomes in many asthmatics. Some studies suggest that patients homozygous for arginine at the 16th amino-acid position of ...

    • Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands 

      van der Molen, Thys; Postma, Dirkje S.; Martin, Richard J.; Herings, Ron M. C.; Overbeek, Jetty A.; Thomas, Victoria; Miglio, Cristiana; Dekhuijzen, Richard; Roche, Nicolas; Guilbert, Theresa; Israel, Elliot; van Aalderen, Wim; Hillyer, Elizabeth V.; van Rysewyk, Simon; Price, David B. (BioMed Central, 2016)
      Background: Most randomised clinical trials typically exclude a significant proportion of asthma patients, including those at higher risk of adverse events, with comorbidities, obesity, poor inhaler technique and adherence, ...

    • Effects of Inhaled Glucocorticoids on Bone Density in Premenopausal Women 

      Israel, Elliot; Banerjee, Taruna; Fitzmaurice, Garrett; Kotlov, Tania; Lahive, Karen; Leboff, Meryl (Massachusetts Medical Society, 2001-09-27)
      Inhaled glucocorticoids are the most commonly used medications for the long-term treatment of patients with asthma. Whether long-term therapy with inhaled glucocorticoids reduces bone mass, as oral glucocorticoid therapy ...

    • Eotaxin Expression after Segmental Allergen Challenge in Subjects with Atopic Asthma 

      Lilly, Craig M.; Nakamura, Hidetoshi; Belostotsky, Olga I.; Haley, Kathleen; Garcia-Zepeda, Eduardo A.; Luster, Andrew; Israel, Elliot (American Thoracic Society, 2001-06)
      Expression of pulmonary eotaxin protein and mRNA was determined in six subjects with atopic asthma and five nonatopic normal subjects. Levels of eotaxin expression and eosinophil mobilization were compared before and after ...

    • Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells 

      Li, Chenggang; Lee, Po-Shun; Sun, Yang; Gu, Xiaoxiao; Zhang, Erik; Guo, Yanan; Wu, Chin-Lee; Auricchio, Neil; Priolo, Carmen; Li, Jing; Csibi, Alfredo; Parkhitko, Andrey; Morrison, Tasha; Planaguma, Anna; Kazani, Shamsah; Israel, Elliot; Xu, Kai-Feng; Henske, Elizabeth Petri; Blenis, John; Levy, Bruce D.; Kwiatkowski, David; Yu, Jane J. (The Rockefeller University Press, 2014)
      Lymphangioleiomyomatosis (LAM) is a progressive neoplastic disorder that leads to lung destruction and respiratory failure primarily in women. LAM is typically caused by tuberous sclerosis complex 2 (TSC2) mutations resulting ...