Browsing by Author "Leiman, Sara"
Now showing items 1-4 of 4
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D-Amino Acids Indirectly Inhibit Biofilm Formation in Bacillus subtilis by Interfering with Protein Synthesis
Leiman, Sara A; May, J. M.; Lebar, M. D.; Kahne, Daniel; Kolter, R.; Losick, Richard M. (American Society for Microbiology, 2013)The soil bacterium Bacillus subtilis forms biofilms on surfaces and at air-liquid interfaces. It was previously reported that these biofilms disassemble late in their life cycle and that conditioned medium from late-stage ... -
Genetics and Regulation of Bacterial Biofilms
Leiman, Sara (2015-03-24)Bacterial biofilm formation, the construction of dense, protective, multicellular communities, is a widely conserved behavior. In some bacteria, such as the Gram-positive model organism Bacillus subtilis, the genetics ... -
Reconstitution of Peptidoglycan Cross-Linking Leads to Improved Fluorescent Probes of Cell Wall Synthesis
Lebar, Matthew D.; May, Janine M.; Meeske, Alexander J.; Leiman, Sara A.; Lupoli, Tania J.; Tsukamoto, Hirokazu; Losick, Richard; Rudner, David Z.; Walker, Suzanne; Kahne, Daniel (American Chemical Society, 2014)The peptidoglycan precursor, Lipid II, produced in the model Gram-positive bacterium Bacillus subtilis differs from Lipid II found in Gram-negative bacteria such as Escherichia coli by a single amidation on the peptide ... -
SinR is a mutational target for fine-tuning biofilm formation in laboratory-evolved strains of Bacillus subtilis
Leiman, Sara A; Arboleda, Laura C; Spina, Joseph S; McLoon, Anna L (BioMed Central, 2014)Background: Bacteria often form multicellular, organized communities known as biofilms, which protect cells from a variety of environmental stresses. During biofilm formation, bacteria secrete a species-specific matrix; ...