Browsing by Author "Desrosiers, Ronald"

Now showing items 1-9 of 9

    • AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges 

      Gardner, Matthew R.; Kattenhorn, Lisa M.; Kondur, Hema R.; von Schaewen, Markus; Dorfman, Tatyana; Chiang, Jessica J.; Haworth, Kevin G.; Decker, Julie M.; Alpert, Michael D.; Bailey, Charles C.; Neale, Ernest S.; Fellinger, Christoph H.; Joshi, Vinita R.; Fuchs, Sebastian P.; Martinez-Navio, Jose M.; Quinlan, Brian D.; Yao, Annie Y.; Mouquet, Hugo; Gorman, Jason; Zhang, Baoshan; Poignard, Pascal; Nussenzweig, Michel C.; Burton, Dennis R.; Kwong, Peter D.; Piatak, Michael; Lifson, Jeffrey D.; Gao, Guangping; Desrosiers, Ronald C.; Evans, David T.; Hahn, Beatrice H.; Ploss, Alexander; Cannon, Paula M.; Seaman, Michael S.; Farzan, Michael (2015)
      Long-term in vivo expression of a broad and potent entry inhibitor could circumvent the need for a conventional vaccine for HIV-1. Adeno-associated virus (AAV) vectors can stably express HIV-1 broadly neutralizing antibodies ...

    • ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against \(SIV_{mac}251\) Challenge 

      Alpert, Michael D.; Harvey, Jackson D.; Piatak, Michael; Carville, Angela; Lifson, Jeffrey D.; Li, Wenjun; Lauer, William A.; Reeves, Roger Keith; Mansfield, Keith G.; Desrosiers, Ronald C.; Johnson, R. Paul; Evans, David T. (Public Library of Science, 2012)
      Live-attenuated strains of simian immunodeficiency virus (SIV) routinely confer apparent sterilizing immunity against pathogenic SIV challenge in rhesus macaques. Understanding the mechanisms of protection by live-attenuated ...

    • Epstein–Barr Virus MicroRNAs Are Evolutionarily Conserved and Differentially Expressed 

      Cai, Xuezhong; Schäfer, Alexandra; Lu, Shihua; Bilello, John P; Desrosiers, Ronald C.; Edwards, Rachel; Raab-Traub, Nancy; Cullen, Bryan R (Public Library of Science, 2006)
      The pathogenic lymphocryptovirus Epstein–Barr virus (EBV) is shown to express at least 17 distinct microRNAs (miRNAs) in latently infected cells. These are arranged in two clusters: 14 miRNAs are located in the introns of ...

    • Functional Contributions of Carbohydrate on AIDS Virus Glycoprotein 

      Stansell, Elizabeth; Desrosiers, Ronald C. (YJBM, 2010)
      Envelope glycoprotein spikes on the surface of the human immunodeficiency virus (HIV) are used by the virus to bind to cellular receptors to gain entry into target cells. As such, the envelope spikes are the targets of ...

    • Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate 

      Stansell, Elizabeth; Panico, Maria; Canis, Kevin; Pang, Poh-Choo; Bouché, Laura; Binet, Daniel; O'Connor, Michael-John; Chertova, Elena; Bess, Julian; Lifson, Jeffrey D.; Haslam, Stuart M.; Morris, Howard R.; Desrosiers, Ronald C.; Dell, Anne (Public Library of Science, 2015)
      As HIV-1-encoded envelope protein traverses the secretory pathway, it may be modified with N- and O-linked carbohydrate. When the gp120s of HIV-1 NL4-3, HIV-1 YU2, HIV-1 Bal, HIV-1 JRFL, and HIV-1 JRCSF were expressed as ...

    • OA06-02. Monospecific Expansion of SIVmac251 During Acute Infection Masks Multiple Transmitted Virus Variants Revealed During the Chronic Phase 

      Felber, BK; Kim, E; Pal, R; Desrosiers, Ronald C.; Wolinsky, SM; Pavlakis, GN (BioMed Central, 2009)

    • Rhesus Monkey Rhadinovirus Uses Eph Family Receptors for Entry into B Cells and Endothelial Cells but Not Fibroblasts 

      Hahn, Alexander Steven; Desrosiers, Ronald C. (Public Library of Science, 2013)
      Cellular Ephrin receptor tyrosine kinases (Ephrin receptors, Ephs) were found to interact efficiently with the gH/gL glycoprotein complex of the rhesus monkey rhadinovirus (RRV). Since EphA2 was recently identified as a ...

    • SIV Vpx Is Essential for Macrophage Infection but Not for Development of AIDS 

      Westmoreland, Susan V.; Converse, A. Peter; Hrecka, Kasia; Hurley, Mollie; Knight, Heather; Piatak, Michael; Lifson, Jeffrey; Mansfield, Keith G.; Skowronski, Jacek; Desrosiers, Ronald C. (Public Library of Science, 2014)
      Analysis of rhesus macaques infected with a vpx deletion mutant virus of simian immunodeficiency virus mac239 (SIVΔvpx) demonstrates that Vpx is essential for efficient monocyte/macrophage infection in vivo but is not ...

    • Systematic Analysis of Intracellular Trafficking Motifs Located within the Cytoplasmic Domain of Simian Immunodeficiency Virus Glycoprotein gp41 

      Postler, Thomas S.; Bixby, Jacqueline G.; Desrosiers, Ronald C.; Yuste, Eloísa (Public Library of Science, 2014)
      Previous studies have shown that truncation of the cytoplasmic-domain sequences of the simian immunodeficiency virus (SIV) envelope glycoprotein (Env) just prior to a potential intracellular-trafficking signal of the ...