Browsing by Author "Inouye, Sharon"
Now showing items 1-20 of 108
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Achieving Goals in Geriatric Assessment: Role of Caregiver Agreement and Adherence to Recommendations
Inouye, Sharon; Bogardus, Sidney; Bradley, Elizabeth; Williams, Christianna; Maciejewski, Paul; Gallo, William (Wiley-Blackwell, 2004)Objectives: To determine predictors of recommendation adherence and goal attainment of family caregivers of patients at a geriatric assessment center. Design: One‐year prospective cohort study. Setting: Outpatient geriatric ... -
Adverse Outcomes After Hospitalization and Delirium in Persons With Alzheimer Disease
Fong, Tamara G.; Jones, Richard N.; Marcantonio, Edward R.; Tommet, Douglas; Gross, Alden L.; Habtemariam, Daniel; Schmitt, Eva; Yap, Liang; Inouye, Sharon (American College of Physicians, 2012)BACKGROUND: Hospitalization, frequently complicated by delirium, can be a life-changing event for patients with Alzheimer disease (AD). OBJECTIVE: To determine risks for institutionalization, cognitive decline, or death ... -
After Adoption: Sustaining the Innovation A Case Study of Disseminating the Hospital Elder Life Program
Inouye, Sharon; Bradley, Elizabeth; Webster, Tashonna; Baker, Dorothy; Schlesinger, Mark (Wiley-Blackwell, 2005)OBJECTIVES: To examine key factors that influence sustainability in the diffusion of the Hospital Elder Life Program (HELP) as an example of an evidence-based, multifaceted, innovative program to improve care for hospitalized ... -
Aging, brain disease, and reserve: Implications for delirium
Jones, Richard Norman; Fong, Tamara G; Metzger, Eran Daniel; Tulebaev, Samir Raisovich; Yang, Frances Margaret; Alsop, David C.; Marcantonio, Edward Ralph; Cupples, L; Gottlieb, Gary L.; Inouye, Sharon (2010)Cognitive and brain reserve are well studied in the context of age-associated cognitive impairment and dementia. However, there is a paucity of research that examines the role of cognitive or brain reserve in delirium. ... -
Aging, Brain Disease, and Reserve: Implications for Delirium
Jones, Richard; Fong, Tamara; Metzger, Eran; Tulebaev, Samir; Yang, Frances; Alsop, David; Marcantonio, Edward; Cupples, L Adrienne; Gottlieb, Gary; Inouye, Sharon (Elsevier BV, 2010-02)Cognitive and brain reserve are well studied in the context of age-associated cognitive impairment and dementia. However, there is a paucity of research that examines the role of cognitive or brain reserve in delirium. ... -
An Algorithm for Prospective Individual Matching in a Non-Randomized Clinical Trial
Inouye, Sharon; Charpentier, Peter; Bogardus, Sidney (Elsevier BV, 2001)A method is described to achieve balance across prognostic factors in intervention trials for which randomized allocation to treatment group is not possible. The method involves prospective individual matching of patients ... -
Alzheimer's-Related Cortical Atrophy Is Associated With Postoperative Delirium Severity in Persons Without Dementia
Racine, Annie M.; Fong, Tamara; Travison, Thomas; Jones, Richard N.; Gou, Yun; Vasunilashorn, Sarinnapha; Marcantonio, Edward; Alsop, David; Inouye, Sharon; Dickerson, Bradford (Elsevier BV, 2017-11)Patients with dementia due to Alzheimer’s disease (AD) have increased risk of developing delirium. This study investigated the relationship between a magnetic resonance imaging (MRI)-derived biomarker associated with ... -
Association between Acute Geriatric Syndromes and Medication-Related Hospital Admissions
Wierenga, Peter C.; Buurman, Bianca M.; Parlevliet, Juliette L.; van Munster, Barbara C.; Smorenburg, Susanne M.; Inouye, Sharon; de Rooij, Sophia E.J.A (Springer Nature, 2012)Background: Elderly patients are at a 4-fold higher risk of adverse drug events (ADEs) and drug-related hospitalization. Hospitalization of an elderly patient is often preceded by geriatric syndromes, like falls or delirium. ... -
Association Between Hospital Readmission and Acute and Sustained Delays in Functional Recovery During 18 Months After Elective Surgery: The Successful Aging after Elective Surgery Study
Pisani, Margaret A.; Albuquerque, Asha; Marcantonio, Edward; Jones, Richard N.; Gou, Ray Yun; Fong, Tamara; Schmitt, Eva M.; Tommet, Douglas; Isaza Aizpurua, Ilean I.; Alsop, David; Inouye, Sharon; Travison, Thomas (Wiley, 2017-01)Objectives: To examine the effect of hospital readmission on functional recovery after elective surgery in older adults. Design: Prospective cohort of individuals aged 70 and older undergoing elective surgery, enrolled ... -
Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction?
Fong, Tamara G; Inouye, Sharon; Dai, Weiying; Press, Daniel; Alsop, David C. (Springer Science + Business Media, 2010)Dementia with Lewy bodies (DLB) is often associated with occipital hypometabolism or hypoperfusion, as well as deficits in cholinergic neurotransmission. In this study, 11 mild DLB, 16 mild AD and 16 age-matched controls ... -
Associations between Caregiver-Perceived Delirium in Patients with Cancer and Generalized Anxiety in their Caregivers
Buss, Mary Kathleen; Vanderwerker, Lauren C.; Inouye, Sharon; Zhang, Baohui; Block, Susan Dale; Prigerson, Holly G. (Mary Ann Liebert Inc, 2007)Background: Delirium, a common complication of advanced cancer, may put caregivers at risk for poor mental health outcomes. We looked for a relationship between caregiver-perceived delirium in a patient with advanced cancer ... -
Barriers and Facilitators to Implementing Delirium Rounds in a Clinical Trial Across Three Diverse Hospital Settings
Yevchak, A. M.; Fick, D. M.; McDowell, J.; Monroe, T.; May, K.; Grove, L.; Kolanowski, A. M.; Waller, J. L.; Inouye, Sharon (SAGE Publications, 2013)Delirium occurs in more than half of hospitalized older adults with dementia, substantially worsening outcomes. The use of multiple strategies and a local opinion leader, unit champion, has cumulative and lasting effects ... -
Benzodiazepine and Opioid Use and the Duration of Intensive Care Unit Delirium in an Older Population*
Inouye, Sharon; Pisani, Margaret; Murphy, Terrence; Araujo, Katy; Slattum, Patricia; Van Ness, Peter (Ovid Technologies (Wolters Kluwer Health), 2009)Objective: There is a high prevalence of delirium in older medical intensive care unit (ICU) patients and delirium is associated with adverse outcomes. We need to identify modifiable risk factors for delirium, such as ... -
Burden of illness score for elderly persons (BISEP): Risk adjustment incorporating the cumulative impact of diseases, physiologic abnormalities and functional impairments.
Inouye, Sharon; Bogardus, Sidney T.; Vitagliano, Gail; Desai, Mayur; Williams, Christianna; Grady, Jacqueline; Scinto, Jeanne (Lippincott Williams & Wilkins, Inc., 2003)Background/Objectives. To develop and validate a new risk adjustment index-the Burden of Illness Score for Elderly Persons (BISEP)-which integrates multiple domains, including diseases, physiologic abnormalities, and ... -
Calibration and Validation of an Innovative Approach for Estimating General Cognitive Performance
Gross, Alden L.; Jones, Richard Norman; Fong, Tamara G; Tommet, Douglas; Inouye, Sharon (S. Karger AG, 2014)Objective: To evaluate a new approach for creating a composite measure of cognitive function, we calibrated a measure of general cognitive performance from existing neuropsychological batteries. Methods: We applied our ... -
The CAM-S: Development and Validation of a New Scoring System for Delirium Severity in 2 Cohorts
Inouye, Sharon; Kosar, Cyrus M.; Tommet, Douglas; Schmitt, Eva M.; Puelle, Margaret R.; Saczynski, Jane S.; Marcantonio, Edward Ralph; Jones, Richard Norman (American College of Physicians, 2014) -
Characteristics Associated With Delirium in Older Patients in a Medical Intensive Care Unit
Pisani, Margaret A.; Murphy, Terrence; Van Ness, Peter; Araujo, Katy; Inouye, Sharon (American Medical Association (AMA), 2007)Background Delirium is a highly prevalent disorder among older patients in the intensive care unit. Methods We performed a prospective cohort study of 304 patients 60 years or older admitted from September 5, 2002, ... -
CHERISH (collaboration for hospitalised elders reducing the impact of stays in hospital): protocol for a multi-site improvement program to reduce geriatric syndromes in older inpatients
Mudge, Alison M.; Banks, Merrilyn D.; Barnett, Adrian G.; Blackberry, Irene; Graves, Nicholas; Green, Theresa; Harvey, Gillian; Hubbard, Ruth E.; Inouye, Sharon K.; Kurrle, Sue; Lim, Kwang; McRae, Prue; Peel, Nancye M.; Suna, Jessica; Young, Adrienne M. (BioMed Central, 2017)Background: Older inpatients are at risk of hospital-associated geriatric syndromes including delirium, functional decline, incontinence, falls and pressure injuries. These contribute to longer hospital stays, loss of ... -
Cholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence
Hshieh, Tammy Ting; Fong, Tamara G; Marcantonio, Edward Ralph; Inouye, Sharon (Oxford University Press (OUP), 2008)Deficits in cholinergic function have been postulated to cause delirium and cognitive decline. This review examines current understanding of the cholinergic deficiency hypothesis in delirium by synthesizing evidence on ... -
Cognitive and Brain Reserve and the Risk of Postoperative Delirium in Older Patients: Analysis of Data From a Prospective Observational Study
Saczynski, Jane; Inouye, Sharon; Kosar, Cyrus; Tommet, Doug; Marcantonio, Edward; Fong, Tamara; Hshieh, Tammy; Vasunilashorn, Sarinnapha; Metzger, Eran; Schmitt, Eva; Alsop, David; Jones, Richard N (Elsevier BV, 2014-11-01)Background Cognitive and brain reserve theories suggest that aspects of neural architecture or cognitive processes modify the impact of neuropathological processes on cognitive outcomes. While frequently studied in the ...