Browsing by Author "Eyal, Nir"
Now showing items 1-7 of 7
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Ethical Comparators in Coronavirus Vaccine Trials
Eyal, Nir; Lipsitch, Marc (2020-03-31) -
HIV Treatment-as-Prevention Research at a Crossroads
Bärnighausen, Till; Eyal, Nir; Wikler, Daniel (Public Library of Science, 2014)In light of changing WHO guidelines for HIV treatment, Till Bärnighausen and colleagues consider how large-scale HIV treatment-as-prevention trials can be adapted so that they can remain viable. Please see later in the ... -
HIV Treatment-As-Prevention Research: Authors’ Reply
Bärnighausen, Till; Eyal, Nir; Wikler, Dan (Public Library of Science, 2015)Till Bärnighausen and colleagues respond to comments by the HPTN 071 (PopART) Study Team, noting the distinction between the different HIV prevention questions the trial will attempt to answer. -
Human Challenge Studies to Accelerate Coronavirus Vaccine Licensure
Eyal, Nir; Lipsitch, Marc; Smith, Peter G. (2020-03)Controlled human challenge trials of SARS-CoV-2 vaccine candidates could accelerate the testing and potential rollout of efficacious vaccines. By replacing conventional Phase 3 testing of vaccine candidates, such trials ... -
Medical students’ characteristics as predictors of career practice location: retrospective cohort study tracking graduates of Nepal’s first medical college
Zimmerman, Mark; Shakya, Rabina; Pokhrel, Bharat M; Eyal, Nir; Rijal, Basista P; Shrestha, Ratindra N; Sayami, Arun (BMJ Publishing Group Ltd., 2012)Objective: To determine, in one low income country (Nepal), which characteristics of medical students are associated with graduate doctors staying to practise in the country or in its rural areas. Design: Observational ... -
Testing SARS-CoV-2 vaccine efficacy through deliberate natural viral exposure
Eyal, Nir; Lipsitch, Marc (2020)A vaccine trial with a standard challenge design can be faster than standard phase III once it starts, but it requires a long prior process, in part, to grow and standardize challenge virus in the laboratory. This detracts ... -
Vaccine testing for emerging infections: the case for individual randomisation
Eyal, Nir; Lipsitch, Marc (BMJ, 2017)During the 2014-2015 Ebola outbreak in Guinea, Liberia and Sierra Leone, many opposed the use of individually randomised controlled trials to test candidate Ebola vaccines. For a raging fatal disease, they explained, it ...