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Advances in Phage-Assisted Continuous Evolution and Application to Overcoming Bioinsecticide Resistance
Badran, Ahmed (2016-05-20)The Bacillus thuringiensis δ-endotoxins (Bt toxins) are widely used insecticidal proteins in engineered crops that provide agricultural, economic, and environmental benefits, constituting a substantial and increasingly ... -
Directed Evolution and Engineering of CRISPR-Associated Nucleases
Davis, Kevin Michael (2016-09-12)CRISPR-Cas systems provide prokaryotes with a remarkable mechanism for adaptive immunity, and recent efforts to understand these systems have provided tremendous insight into the complex nature of these systems. Despite ... -
Therapeutic potential and physiological roles of Insulin-Degrading Enzyme illuminated by a DNA-templated macrocyclic inhibitor
Maianti, Juan Pablo (2015-05-19)Insulin-Degrading Enzyme (IDE) is a zinc-metalloprotease responsible for the clearance of insulin in peripheral tissues. Despite decades of speculation that inhibiting endogenous insulin degradation might treat Type-2 ...