Browsing by Author "Avorn, Jerome"
Now showing items 1-20 of 34
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Association of Medical Students' Reports of Interactions with the Pharmaceutical and Medical Device Industries and Medical School Policies and Characteristics: A Cross-Sectional Study
Yeh, James S.; Austad, Kirsten E.; Franklin, Jessica M.; Chimonas, Susan; Campbell, Eric G.; Avorn, Jerry; Kesselheim, Aaron S. (Public Library of Science, 2014)Background: Professional societies use metrics to evaluate medical schools' policies regarding interactions of students and faculty with the pharmaceutical and medical device industries. We compared these metrics and ... -
Burden of Changes in Pill Appearance for Patients Receiving Generic Cardiovascular Medications After Myocardial Infarction
Kesselheim, Aaron Seth; Bykov, Katsiaryna; Avorn, Jerry Lewis; Tong, Angela; Doherty, Michael Joseph; Choudhry, Niteesh Kumar (American College of Physicians, 2014)Background: Generic prescription drugs made by different manufacturers may vary in color or shape, and switching among these drug products may interrupt medication use. Objective: To determine whether nonpersistent use of ... -
Changing Surgical Antimicrobial Prophylaxis Practices through Education Targeted at Senior Department Leaders
Everitt, Daniel E.; Soumerai, Stephen Bertram; Avorn, Jerry Lewis; Klapholz, Henry; Wessels, Michael Robert (Cambridge University Press (CUP), 1990)Prescribing antibiotics for perioperative prophylaxis in common surgical procedures presents an ideal target for educational intervention. In this situation, antibiotics are often used inappropriately, with consequent ... -
Clinicians’ Contributions to the Development of Coronary Artery Stents: A Qualitative Study of Transformative Device Innovation
Kesselheim, Aaron S.; Xu, Shuai; Avorn, Jerry (Public Library of Science, 2014)Background: Medical device innovation remains poorly understood, and policymakers disagree over how to incentivize early development. We sought to elucidate the components of transformative health care innovation by ... -
Comparative Effectiveness of Generic and Brand-Name Statins on Patient Outcomes
Gagne, Joshua J; Choudhry, Niteesh Kumar; Kesselheim, Aaron Seth; Polinski, Jennifer Milan; Hutchins, David; Matlin, Olga S.; Brennan, Troyen Anthony; Avorn, Jerry Lewis; Shrank, William (American College of Physicians, 2014)Background: Statins are effective in preventing cardiovascular events, but patients do not fully adhere to them. Objective: To determine whether patients are more adherent to generic statins versus brand-name statins ... -
Comparative effectiveness of generic versus brand-name antiepileptic medications
Gagne, Joshua J; Kesselheim, Aaron Seth; Choudhry, Niteesh Kumar; Polinski, Jennifer Milan; Hutchins, David; Matlin, Olga S.; Brennan, Troyen Anthony; Avorn, Jerry Lewis; Shrank, William (Elsevier BV, 2015)OBJECTIVE: The objective of this study was to compare treatment persistence and rates of seizure-related events in patients who initiate antiepileptic drug (AED) therapy with a generic versus a brand-name product. METHODS: ... -
Conflict of Interest Reporting by Authors Involved in Promotion of Off-Label Drug Use: An Analysis of Journal Disclosures
Kesselheim, Aaron Seth; Wang, Bo; Studdert, David Michael; Avorn, Jerry Lewis (Public Library of Science, 2012)Background: Litigation documents reveal that pharmaceutical companies have paid physicians to promote off-label uses of their products through a number of different avenues. It is unknown whether physicians and scientists ... -
A Controlled Trial of Educational Outreach to Improve Blood Transfusion Practice
Soumerai, Stephen Bertram; Salem-Schatz, Susanne; Avorn, Jerry Lewis (American Medical Association (AMA), 1993)Objective. —To determine whether brief, face-to-face educational outreach visits can improve the appropriateness of blood product utilization. Design. —Randomized, controlled multicenter trial with 6-month ... -
Development of a Health Care Utilisation Data-Based Index for Rheumatoid Arthritis Severity: A Preliminary Study
Ting, Gladys; Schneeweiss, Sebastian; Scranton, Richard E.; Katz, Jeffrey; Weinblatt, Michael; Young, Melissa; Avorn, Jerome; Solomon, Daniel (Springer Science and Business Media LLC, 2008-08-21)Introduction Health care utilisation ('claims') databases contain information about millions of patients and are an important source of information for a variety of study types. However, they typically do not contain ... -
Differential Risk of Death in Older Residents in Nursing Homes Prescribed Specific Antipsychotic Drugs: Population Based Cohort Study
Huybrechts, Krista F.g.; Gerhard, T; Crystal, S; Olfson, M; Avorn, Jerry Lewis; Levin, Robert Marc; Lucas, J. A.; Schneeweiss, Sebastian (BMJ Publishing Group Ltd., 2012)Objective: To assess risks of mortality associated with use of individual antipsychotic drugs in elderly residents in nursing homes. Design Population based cohort study with linked data from Medicaid, Medicare, the Minimum ... -
Effect of smoking on comparative efficacy of antiplatelet agents: systematic review, meta-analysis, and indirect comparison
Gagne, Joshua J; Bykov, Katsiaryana; Choudhry, Niteesh K; Toomey, Timothy J; Connolly, John G; Avorn, Jerry (BMJ Publishing Group Ltd., 2013)Objective: To evaluate whether smoking status is associated with the efficacy of antiplatelet treatment in the prevention of cardiovascular events. Design: Systematic review, meta-analysis, and indirect comparisons. Data ... -
Effects of Medicaid Drug-Payment Limits on Admission to Hospitals and Nursing Homes
Soumerai, Stephen Bertram; Ross-Degnan, Dennis; Avorn, Jerry Lewis; McLaughlin, Thomas J.; Choodnovskiy, Igor (New England Journal of Medicine (NEJM/MMS), 1991)BACKGROUND. Many state Medicaid programs limit the number of reimbursable medications that a patient can receive. We hypothesized that such limitations may lead to exacerbations of illness or to admissions to institutions ... -
Equity in the Receipt of Oseltamivir in the United States During the H1N1 Pandemic
Franklin, Jessica Myers; Choudhry, Niteesh Kumar; Uscher-Pines, Lori; Brill, Gregory; Matlin, Olga S.; Fischer, Michael Adam; Schneeweiss, Sebastian; Avorn, Jerry Lewis; Brennan, Troyen Anthony; Shrank, William (American Public Health Association, 2014)Objectives. We assessed the relationship between individual characteristics and receipt of oseltamivir (Tamiflu) in the United States during the H1N1 pandemic and other flu seasons. Methods. In a cohort of individuals ... -
Five Features Of Value-Based Insurance Design Plans Were Associated With Higher Rates Of Medication Adherence
Choudhry, Niteesh Kumar; Fischer, Michael Adam; Smith, B. F.; Brill, G.; Girdish, C.; Matlin, O. S.; Brennan, Troyen Anthony; Avorn, Jerry Lewis; Shrank, W (Health Affairs (Project Hope), 2014)Value-based insurance design (VBID) plans selectively lower cost sharing to increase medication adherence. Existing plans have been structured in a variety of ways, and these variations could influence the effectiveness ... -
Improving Drug-Therapy Decisions through Educational Outreach
Avorn, Jerry Lewis; Soumerai, Stephen Bertram (New England Journal of Medicine (NEJM/MMS), 1983)Improving precision and economy in the prescribing of drugs is a goal whose importance has increased with the proliferation of new and potent agents and with growing economic pressures to contain healthcare costs. We ... -
Influence of Clinical Knowledge, Organizational Context, and Practice Style on Transfusion Decision Making
Salem-Schatz, Susanne R.; Avorn, Jerry Lewis; Soumerai, Stephen Bertram (American Medical Association (AMA), 1990)Evidence shows that blood products, like other health care resources, are often used inappropriately, but the reasons for this have not been well studied. We conducted a face-to-face survey of 122 general surgeons, orthopedic ... -
Interventions to Improve Adherence and Persistence With Osteoporosis Medications: A Systematic Literature Review
Gleeson, T.; Iversen, Maura Daly; Avorn, Jerry Lewis; Brookhart, A. M.; Katz, Jeffrey Neil; Losina, Elena; May, F.; Patrick, A. R.; Shrank, W; Solomon, Daniel Hal; Solomon, Daniel Hal (Springer Science + Business Media, 2009-06-05)Summary: Adherence and persistence with osteoporosis medications are poor. We conducted a systematic literature review of interventions to improve adherence and persistence with osteoporosis medications. Seven studies met ... -
Medicaid prescription limits: policy trends and comparative impact on utilization
Lieberman, Daniel A.; Polinski, Jennifer M.; Choudhry, Niteesh K.; Avorn, Jerry; Fischer, Michael A. (BioMed Central, 2016)Background: Medicaid programs face growing pressure to control spending. Despite evidence of clinical harms, states continue to impose policies limiting the number of reimbursable prescriptions (caps). We examined the ... -
Medication Adherence and Healthcare Disparities: Impact of Statin Co-Payment Reduction
Lewey, Jennifer; Shrank, William; Avorn, Jerry Lewis; Liu, Jun; Choudhry, Niteesh Kumar (Managed Care & Healthcare Communications, 2015)Objectives: Minority patients have lower rates of cardiovascularmedication adherence, which may be amenable to co-payment reductions.Our objective was to evaluate the effect of race on adherencechanges following a statin ... -
Patient, Physician, and Payment Predictors of Statin Adherence
Chan, David Chimin; Shrank, William H.; Cutler, David M.; Jan, Saira; Fischer, Michael Adam; Liu, Jun; Avorn, Jerry Lewis; Solomon, Daniel Hal; Brookhart, Alan; Choudhry, Niteesh K (American Public Health Association, 2010)BACKGROUND: Although many patient, physician, and payment predictors of adherence have been described, knowledge of their relative strength and overall ability to explain adherence is limited. OBJECTIVES: To measure the ...