Browsing by Author "Taatjes, Dylan J."
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Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics
Poss, Zachary C.; Ebmeier, Christopher C.; Odell, Aaron T.; Tangpeerachaikul, Anupong; Lee, Thomas; Pelish, Henry Efrem; Shair, Matthew David; Dowell, Robin D.; Old, William M.; Taatjes, Dylan J. (Elsevier BV, 2016)Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we now report a large-scale identification of Mediator kinase substrates in human cells (HCT116). We identified over ...