Browsing by Author "Ra, Young Shin"

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    • TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma 

      Remke, Marc; Ramaswamy, Vijay; Peacock, John; Shih, David J. H.; Koelsche, Christian; Northcott, Paul A.; Hill, Nadia; Cavalli, Florence M. G.; Kool, Marcel; Wang, Xin; Mack, Stephen C.; Barszczyk, Mark; Morrissy, A. Sorana; Wu, Xiaochong; Agnihotri, Sameer; Luu, Betty; Jones, David T. W.; Garzia, Livia; Dubuc, Adrian M.; Zhukova, Nataliya; Vanner, Robert; Kros, Johan M.; French, Pim J.; Van Meir, Erwin G.; Vibhakar, Rajeev; Zitterbart, Karel; Chan, Jennifer A.; Bognár, László; Klekner, Almos; Lach, Boleslaw; Jung, Shin; Saad, Ali G.; Liau, Linda M.; Albrecht, Steffen; Zollo, Massimo; Cooper, Michael K.; Thompson, Reid C.; Delattre, Oliver O.; Bourdeaut, Franck; Doz, François F.; Garami, Miklós; Hauser, Peter; Carlotti, Carlos G.; Van Meter, Timothy E.; Massimi, Luca; Fults, Daniel; Pomeroy, Scott L.; Kumabe, Toshiro; Ra, Young Shin; Leonard, Jeffrey R.; Elbabaa, Samer K.; Mora, Jaume; Rubin, Joshua B.; Cho, Yoon-Jae; McLendon, Roger E.; Bigner, Darell D.; Eberhart, Charles G.; Fouladi, Maryam; Wechsler-Reya, Robert J.; Faria, Claudia C.; Croul, Sidney E.; Huang, Annie; Bouffet, Eric; Hawkins, Cynthia E.; Dirks, Peter B.; Weiss, William A.; Schüller, Ulrich; Pollack, Ian F.; Rutkowski, Stefan; Meyronet, David; Jouvet, Anne; Fèvre-Montange, Michelle; Jabado, Nada; Perek-Polnik, Marta; Grajkowska, Wieslawa A.; Kim, Seung-Ki; Rutka, James T.; Malkin, David; Tabori, Uri; Pfister, Stefan M.; Korshunov, Andrey; von Deimling, Andreas; Taylor, Michael D. (Springer Berlin Heidelberg, 2013)
      Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT ...

    • WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma 

      Zhukova, Nataliya; Ramaswamy, Vijay; Remke, Marc; Martin, Dianna C; Castelo-Branco, Pedro; Zhang, Cindy H; Fraser, Michael; Tse, Ken; Poon, Raymond; Shih, David JH; Baskin, Berivan; Ray, Peter N; Bouffet, Eric; Dirks, Peter; von Bueren, Andre O; Pfaff, Elke; Korshunov, Andrey; Jones, David TW; Northcott, Paul A; Kool, Marcel; Pugh, Trevor J; Pomeroy, Scott L; Cho, Yoon-Jae; Pietsch, Torsten; Gessi, Marco; Rutkowski, Stefan; Bognár, Laszlo; Cho, Byung-Kyu; Eberhart, Charles G; Conter, Cecile Faure; Fouladi, Maryam; French, Pim J; Grajkowska, Wieslawa A; Gupta, Nalin; Hauser, Peter; Jabado, Nada; Vasiljevic, Alexandre; Jung, Shin; Kim, Seung-Ki; Klekner, Almos; Kumabe, Toshihiro; Lach, Boleslaw; Leonard, Jeffrey R; Liau, Linda M; Massimi, Luca; Pollack, Ian F; Ra, Young Shin; Rubin, Joshua B; Van Meir, Erwin G; Wang, Kyu-Chang; Weiss, William A; Zitterbart, Karel; Bristow, Robert G; Alman, Benjamin; Hawkins, Cynthia E; Malkin, David; Clifford, Steven C; Pfister, Stefan M; Taylor, Michael D; Tabori, Uri (BioMed Central, 2014)
      TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance ...