Browsing by Author "Gabuzda, Dana"
Now showing items 1-20 of 20
-
Applications and Limitations of Inflammatory Biomarkers for Studies on Neurocognitive Impairment in HIV Infection
Cassol, Edana; Misra, Vikas; Morgello, Susan; Gabuzda, Dana (Springer US, 2013)Despite reduced prevalence of severe forms of HIV-associated neurocognitive disorders (HAND) on current antiretroviral therapy (ART) regimens, milder forms of neurocognitive impairment (NCI) remain prevalent in HIV-infected ... -
Asn 362 in gp120 Contributes to Enhanced Fusogenicity by CCR5-restricted HIV-1 Envelope Glycoprotein Variants from Patients with AIDS
Sterjovski, Jasminka; Churchill, Melissa J; Ellett, Anne; Gray, Lachlan R; Roche, Michael J; Dunfee, Rebecca L; Purcell, Damian FJ; Saksena, Nitin; Sonza, Secondo; Wesselingh, Steven L; Karlsson, Ingrid; Fenyo, Eva-Maria; Cunningham, Anthony L; Gorry, Paul R; Wang, Bin; Gabuzda, Dana Helga (BioMed Central, 2007)Background: CCR5-restricted (R5) human immunodeficiency virus type 1 (HIV-1) variants cause CD4+ T-cell loss in the majority of individuals who progress to AIDS, but mechanisms underlying the pathogenicity of R5 strains ... -
Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment
Cassol, Edana; Misra, Vikas; Dutta, Anupriya; Morgello, Susan; Gabuzda, Dana (Lippincott Williams & Wilkins, 2014)Objective(s): HIV-associated neurocognitive disorders (HAND) remain prevalent in HIV-infected patients on antiretroviral therapy (ART), but the underlying mechanisms are unclear. Some features of HAND resemble those of ... -
Elicitation from Virus-Naive Individuals of Cytotoxic T Lymphocytes Directed Against Conserved HIV-1 Epitopes
Reche, Pedro A.; Keskin, Derin Benerci; Hussey, Rebecca E.; Ancuta, Petronela; Gabuzda, Dana Helga; Reinherz, Ellis Leonard (BioMed Central, 2006)Cytotoxic T lymphocytes (CTL) protect against viruses including HIV-1. To avoid viral escape mutants that thwart immunity, we chose 25 CTL epitopes defined in the context of natural infection with functional and/or structural ... -
Enhanced Macrophage Tropism of HIV in Brain and Lymphoid Tissues is Associated with Sensitivity to the Broadly Neutralizing CD4 Binding Site Antibody b12
Dunfee, Rebecca L; Thomas, Elaine R; Gabuzda, Dana Helga (BioMed Central, 2009)Macrophages in the central nervous system (CNS) and other tissues are an important cellular reservoir for human immunodeficiency virus type 1 (HIV) infection, particularly in the later stages of disease. Macrophage-tropic ... -
HIVBrainSeqDB: A Database of Annotated HIV Envelope Sequences from Brain and Other Anatomical Sites
Holman, Alexander G; Mefford, Megan E.; O'Connor, Niall; Gabuzda, Dana Helga (BioMed Central, 2010)Background: The population of HIV replicating within a host consists of independently evolving and interacting sub-populations that can be genetically distinct within anatomical compartments. HIV replicating within the ... -
Integrative analysis of gene and miRNA expression profiles with transcription factor–miRNA feed-forward loops identifies regulators in human cancers
Yan, Zhenyu; Shah, Parantu K.; Amin, Samir B.; Samur, Mehmet K.; Huang, Norman; Wang, Xujun; Misra, Vikas; Ji, Hongbin; Gabuzda, Dana Helga; Li, Cheng (Oxford University Press, 2012)We describe here a novel method for integrating gene and miRNA expression profiles in cancer using feed-forward loops (FFLs) consisting of transcription factors (TFs), miRNAs and their common target genes. The dChip-GemiNI ... -
A Machine Learning Approach for Identifying Amino Acid Signatures in the HIV Env Gene Predictive of Dementia
Holman, Alexander G.; Gabuzda, Dana Helga (Public Library of Science, 2012)The identification of nucleotide sequence variations in viral pathogens linked to disease and clinical outcomes is important for developing vaccines and therapies. However, identifying these genetic variations in rapidly ... -
Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients
Ancuta, Petronela; Kunstman, Kevin J.; Kim, Eun-Young; Autissier, Patrick; Zaman, Tauheed; Stone, David; Morgello, Susan; Singer, Elyse J.; Wolinsky, Steven M.; Kamat, Anupa U; Wurcel, Alysse Gail; Mefford, Megan; Gabuzda, Dana Helga (Public Library of Science, 2008)Elevated plasma lipopolysaccharide (LPS), an indicator of microbial translocation from the gut, is a likely cause of systemic immune activation in chronic HIV infection. LPS induces monocyte activation and trafficking into ... -
Molecular and Bioinformatic Analysis of Neurotropic HIV Envelope Glycoproteins
Mefford, Megan (2012-08-15)Human immunodeficiency virus (HIV) infection of macrophages in brain and other tissues plays an important role in development of HIV-associated neurological disorders and other aspects of disease pathogenesis. Macrophages ... -
Monocyte Activation Markers in Cerebrospinal Fluid Associated With Impaired Neurocognitive Testing in Advanced HIV Infection
Kamat, Anupa; Lyons, Jennifer; Misra, Vikas; Uno, Hajime; Morgello, Susan; Singer, Elyse J.; Gabuzda, Dana (Ovid Technologies (Wolters Kluwer Health), 2012-07-01)Background Activated monocytes/macrophages play a role in severe forms of HIV-associated neurocognitive disorders (HAND), but little is known about mechanisms driving milder forms that are prevalent despite combination ... -
A Novel Exocyst-Based Mechanism for HIV Nef-Mediated Enhancement of Intercellular Nanotube Formation
Mukerji, Joya (2013-02-13)HIV-1 Nef protein contributes to pathogenesis via multiple functions that include enhancement of viral replication and infectivity, alteration of intracellular trafficking, and modulation of cellular signaling pathways. ... -
Pathogenicity and Immunogenicity of Attenuated, nef-deleted HIV-1 Strains In Vivo
Gorry, Paul R; McPhee, Dale A; Verity, Erin; Dyer, Wayne B; Wesselingh, Steven L; Learmont, Jennifer; Roche, Michael; Zaunders, John J; Crowe, Suzanne M; Lewin, Sharon R; Brew, Bruce J; Cunningham, Anthony L; Churchill, Melissa J; Sullivan, John S.; Gabuzda, Dana Helga; Mills, John (BioMed Central, 2007)In efforts to develop an effective vaccine, sterilizing immunity to primate lentiviruses has only been achieved by the use of live attenuated viruses carrying major deletions in nef and other accessory genes. Although live ... -
Phenotype and Envelope Gene Diversity of Nef-Deleted HIV-1 Isolated from Long-Term Survivors Infected from a Single Source
Gray, Lachlan; Churchill, Melissa J; Sterjovski, Jasminka; Witlox, Kristie; Learmont, Jennifer C; Wesselingh, Steven L; Cunningham, Anthony L; McPhee, Dale A; Gorry, Paul R; Sullivan, John S.; Gabuzda, Dana Helga (BioMed Central, 2007)Background: The Sydney blood bank cohort (SBBC) of long-term survivors consists of multiple individuals infected with attenuated, nef-deleted variants of human immunodeficiency virus type 1 (HIV-1) acquired from a single ... -
A Plasma Biomarker Signature of Immune Activation in HIV Patients on Antiretroviral Therapy
Kamat, Anupa U; Misra, Vikas; Cassol, Edana; Ancuta, Petronela; Yan, Zhenyu; Li, Cheng; Morgello, Susan; Gabuzda, Dana Helga (Public Library of Science, 2012)Background: Immune activation is a strong predictor of disease progression in HIV infection. Combinatorial plasma biomarker signatures that represent surrogate markers of immune activation in both viremic and aviremic HIV ... -
Plasma metabolomics identifies lipid abnormalities linked to markers of inflammation, microbial translocation, and hepatic function in HIV patients receiving protease inhibitors
Cassol, Edana; Misra, Vikas; Holman, Alexander; Kamat, Anupa U; Morgello, Susan; Gabuzda, Dana Helga (BioMed Central, 2013)Background: Metabolic abnormalities are common in HIV-infected individuals on antiretroviral therapy (ART), but the biochemical details and underlying mechanisms of these disorders have not been defined. Methods: Untargeted ... -
Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation
Mukerji, Joya; Olivieri, Kevin Charles; Misra, Vikas; Agopian, Kristin A; Gabuzda, Dana Helga (BioMed Central, 2012)Background: HIV-1 Nef protein contributes to pathogenesis via multiple functions that include enhancement of viral replication and infectivity, alteration of intracellular trafficking, and modulation of cellular signaling ... -
Serological Markers for Inflammatory Bowel Disease in AIDS Patients with Evidence of Microbial Translocation
Kamat, Anupa U; Ancuta, Petronela; Blumberg, Richard Steven; Gabuzda, Dana Helga (Public Library of Science, 2010)Background: Breakdown of the gut mucosal barrier during chronic HIV infection allows translocation of bacterial products such as lipopolysaccharides (LPS) from the gut into the circulation. Microbial translocation also ... -
SIV envelope glycoprotein determinants of macrophage tropism and their relationship to neutralization sensitivity and CD4-independent cell-to-cell transmission
Yen, Po-Jen (2013-10-15)Macrophages are target cells for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection that serve as viral reservoirs in brain, lung, gut, and other tissues, and play important roles in disease ... -
Transcriptional Profiling Reveals Developmental Relationship and Distinct Biological Functions of CD16+ and CD16- Monocyte Subsets
Ancuta, Petronela; Liu, Kuang-Yu; Misra, Vikas; Wacleche, Vanessa Sue; Gosselin, Annie; Zhou, Xiaobo; Gabuzda, Dana Helga (BioMed Central, 2009)Background: Human peripheral blood monocytes (Mo) consist of subsets distinguished by expression of CD16 (FCγRIII) and chemokine receptors. Classical CD16- Mo express CCR2 and migrate in response to CCL2, while a minor ...