Browsing by Author "Kazani, S"

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    • Corticosteroid Suppression of Lipoxin A\(_4\) and Leukotriene B\(_4\) from Alveolar Macrophages in Severe Asthma 

      Bhavsar, Pankaj K; Levy, Bruce David; Hew, Mark J; Pfeffer, Michael A; Kazani, Shamsah; Israel, Elliot; Chung, Kian Fan (BioMed Central, 2010)
      Background: An imbalance in the generation of pro-inflammatory leukotrienes, and counter-regulatory lipoxins is present in severe asthma. We measured leukotriene B\(_4\) (LTB\(_4\)), and lipoxin A\(_4\) (LXA\(_4\)) production ...

    • Cysteinyl Leukotriene Antagonism Inhibits Bronchoconstriction in Respose to Hypertonic Saline Inhalation in Asthma 

      Kazani, S; Sadeh, J; Bunga, S; Wechsler, ME; Israel, Elliot
      Background: In asthma, cysteinyl leukotrienes (CysLTs) play varying roles in the bronchomotor response to multiple provocative stimuli. The contribution of CysLTs on the airway's response to hypertonic saline (HS) inhalation ...

    • Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells 

      Li, Chenggang; Lee, Po-Shun; Sun, Yang; Gu, Xiaoxiao; Zhang, Erik; Guo, Yanan; Wu, Chin-Lee; Auricchio, Neil; Priolo, Carmen; Li, Jing; Csibi, Alfredo; Parkhitko, Andrey; Morrison, Tasha; Planaguma, Anna; Kazani, Shamsah; Israel, Elliot; Xu, Kai-Feng; Henske, Elizabeth Petri; Blenis, John; Levy, Bruce D.; Kwiatkowski, David; Yu, Jane J. (The Rockefeller University Press, 2014)
      Lymphangioleiomyomatosis (LAM) is a progressive neoplastic disorder that leads to lung destruction and respiratory failure primarily in women. LAM is typically caused by tuberous sclerosis complex 2 (TSC2) mutations resulting ...

    • LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma 

      Kazani, Shamsah; Arm, Jonathan P; Boyce, Joshua; Chhay, Heng; Dutile, Stefanie; Wechsler, Michael E; Govindarajulu, Usha; Ivester, Priscilla; Ainsworth, Hannah C; Sergeant, Susan; Chilton, Floyd H; Israel, Elliot (Springer International Publishing, 2014)
      Botanical seed oils reduce the generation of leukotrienes in patients with asthma. Our objective was to determine the efficacy of a botanical seed oil combination against airflow obstruction in asthma, and to determine the ...