Browsing by Author "Choudhry, Niteesh"

Now showing items 1-20 of 28

    • Association Between Trajectories of Statin Adherence and Subsequent Cardiovascular Events 

      Franklin, Jessica Myers; Krumme, Alexis Ann; Tong, Angela Y.; Shrank, William; Matlin, Olga S.; Brennan, Troyen Anthony; Choudhry, Niteesh (Wiley-Blackwell, 2015)
      PURPOSE: Trajectory models have been shown to (1) identify groups of patients with similar patterns of medication filling behavior and (2) summarize the trajectory, the average adherence in each group over time. However, ...

    • Attitudes to Mesalamine Questionnaire: A Novel Tool to Predict Mesalamine Nonadherence in Patients with IBD 

      Moss, Alan C; Lillis, Yvonne; Edwards George, Jessica B.; Choudhry, Niteesh Kumar; Berg, Anders Hayden; Cheifetz, Adam S.; Horowitz, Gary Leigh; Leffler, Daniel Alexander (Springer Nature, 2014)
      OBJECTIVES: Poor adherence to mesalamine is common and driven by a combination of lifestyle and behavioral factors, as well as health beliefs. We sought to develop a valid tool to identify barriers to patient adherence and ...

    • Availability and utilization of cardiovascular fixed-dose combination drugs in the United States 

      Wang, Bo; Choudhry, Niteesh Kumar; Gagne, Joshua J; Landon, Joan; Kesselheim, Aaron Seth (Elsevier BV, 2015)
      BACKGROUND: Solid clinical evidence supports the effectiveness and safety of multiple drugs in treating diabetes, dyslipidemia, and hypertension, and numerous fixed-dose combination products (FDCs) containing such drugs ...

    • Burden of Changes in Pill Appearance for Patients Receiving Generic Cardiovascular Medications After Myocardial Infarction 

      Kesselheim, Aaron Seth; Bykov, Katsiaryna; Avorn, Jerry Lewis; Tong, Angela; Doherty, Michael Joseph; Choudhry, Niteesh Kumar (American College of Physicians, 2014)
      Background: Generic prescription drugs made by different manufacturers may vary in color or shape, and switching among these drug products may interrupt medication use. Objective: To determine whether nonpersistent use of ...

    • Can purchasing information be used to predict adherence to cardiovascular medications? An analysis of linked retail pharmacy and insurance claims data 

      Krumme, Alexis A; Sanfélix-Gimeno, Gabriel; Franklin, Jessica M; Isaman, Danielle L; Mahesri, Mufaddal; Matlin, Olga S; Shrank, William H; Brennan, Troyen A; Brill, Gregory; Choudhry, Niteesh K (BMJ Publishing Group, 2016)
      Objective: The use of retail purchasing data may improve adherence prediction over approaches using healthcare insurance claims alone. Design: Retrospective. Setting and participants A cohort of patients who received ...

    • Comparative Effectiveness of Generic and Brand-Name Statins on Patient Outcomes 

      Gagne, Joshua J; Choudhry, Niteesh Kumar; Kesselheim, Aaron Seth; Polinski, Jennifer Milan; Hutchins, David; Matlin, Olga S.; Brennan, Troyen Anthony; Avorn, Jerry Lewis; Shrank, William (American College of Physicians, 2014)
      Background: Statins are effective in preventing cardiovascular events, but patients do not fully adhere to them. Objective: To determine whether patients are more adherent to generic statins versus brand-name statins ...

    • Comparative effectiveness of generic versus brand-name antiepileptic medications 

      Gagne, Joshua J; Kesselheim, Aaron Seth; Choudhry, Niteesh Kumar; Polinski, Jennifer Milan; Hutchins, David; Matlin, Olga S.; Brennan, Troyen Anthony; Avorn, Jerry Lewis; Shrank, William (Elsevier BV, 2015)
      OBJECTIVE: The objective of this study was to compare treatment persistence and rates of seizure-related events in patients who initiate antiepileptic drug (AED) therapy with a generic versus a brand-name product. METHODS: ...

    • Despite increased use and sales of statins in India, per capita prescription rates remain far below high-income countries 

      Choudhry, Niteesh K; Dugani, Sagar; Shrank, William; Polinski, Jennifer Milan; Stark, Christina E.; Gupta, Rajeev; Prabhakaran, Dorairaj; Brill, Gregory; Jha, Prabhat (Project HOPE, 2014)
      Statin use has increased substantially in North America and Europe, with resultant reductions in cardiovascular mortality. However, little is known about statin use in lower-income countries. India is of interest because ...

    • Effect of smoking on comparative efficacy of antiplatelet agents: systematic review, meta-analysis, and indirect comparison 

      Gagne, Joshua J; Bykov, Katsiaryana; Choudhry, Niteesh K; Toomey, Timothy J; Connolly, John G; Avorn, Jerry (BMJ Publishing Group Ltd., 2013)
      Objective: To evaluate whether smoking status is associated with the efficacy of antiplatelet treatment in the prevention of cardiovascular events. Design: Systematic review, meta-analysis, and indirect comparisons. Data ...

    • Effects of Xanthine Oxidase Inhibitors on Cardiovascular Disease in Patients with Gout: A Cohort Study 

      Kim, Seoyoung Catherine; Schneeweiss, Sebastian; Choudhry, Niteesh Kumar; Liu, Jun; Glynn, Robert James; Solomon, Daniel Hal (Elsevier BV, 2015)
      BACKGROUND: Hyperuricemia and gout are associated with an increased risk of cardiovascular disease (CVD). It is unknown whether treating hyperuricemia with xanthine oxidase inhibitors (XOIs), including allopurinol and ...

    • Equity in the Receipt of Oseltamivir in the United States During the H1N1 Pandemic 

      Franklin, Jessica Myers; Choudhry, Niteesh Kumar; Uscher-Pines, Lori; Brill, Gregory; Matlin, Olga S.; Fischer, Michael Adam; Schneeweiss, Sebastian; Avorn, Jerry Lewis; Brennan, Troyen Anthony; Shrank, William (American Public Health Association, 2014)
      Objectives. We assessed the relationship between individual characteristics and receipt of oseltamivir (Tamiflu) in the United States during the H1N1 pandemic and other flu seasons. Methods. In a cohort of individuals ...

    • Five Features Of Value-Based Insurance Design Plans Were Associated With Higher Rates Of Medication Adherence 

      Choudhry, Niteesh Kumar; Fischer, Michael Adam; Smith, B. F.; Brill, G.; Girdish, C.; Matlin, O. S.; Brennan, Troyen Anthony; Avorn, Jerry Lewis; Shrank, W (Health Affairs (Project Hope), 2014)
      Value-based insurance design (VBID) plans selectively lower cost sharing to increase medication adherence. Existing plans have been structured in a variety of ways, and these variations could influence the effectiveness ...

    • Group-based Trajectory Models: A New Approach to Classifying and Predicting Long-Term Medication Adherence 

      Franklin, Jessica Myers; Shrank, William; Pakes, Juliana; Sanfélix-Gimeno, Gabriel; Matlin, Olga S.; Brennan, Troyen Anthony; Choudhry, Niteesh Kumar (Ovid Technologies (Wolters Kluwer Health), 2013)
      BACKGROUND: Classifying medication adherence is important for efficiently targeting adherence improvement interventions. The purpose of this study was to evaluate the use of a novel method, group-based trajectory models, ...

    • Impact of adverse events on prescribing warfarin in patients with atrial fibrillation: matched pair analysis 

      Choudhry, Niteesh Kumar; Anderson, Geoffrey M.; Laupacis, Andreas; Ross-Degnan, Dennis; Normand, Sharon-Lise Teresa; Soumerai, Stephen Bertram (BMJ, 2006)
      Objectives To quantify the influence of physicians' experiences of adverse events in patients with atrial fibrillation who were taking warfarin. Design Population based, matched pair before and after analysis. Setting ...

    • Medicaid prescription limits: policy trends and comparative impact on utilization 

      Lieberman, Daniel A.; Polinski, Jennifer M.; Choudhry, Niteesh K.; Avorn, Jerry; Fischer, Michael A. (BioMed Central, 2016)
      Background: Medicaid programs face growing pressure to control spending. Despite evidence of clinical harms, states continue to impose policies limiting the number of reimbursable prescriptions (caps). We examined the ...

    • Medication Adherence and Healthcare Disparities: Impact of Statin Co-Payment Reduction 

      Lewey, Jennifer; Shrank, William; Avorn, Jerry Lewis; Liu, Jun; Choudhry, Niteesh Kumar (Managed Care & Healthcare Communications, 2015)
      Objectives: Minority patients have lower rates of cardiovascularmedication adherence, which may be amenable to co-payment reductions.Our objective was to evaluate the effect of race on adherencechanges following a statin ...

    • Near-Real-Time Monitoring of New Drugs: An Application Comparing Prasugrel Versus Clopidogrel 

      Gagne, Joshua J; Rassen, Jeremy Alfred; Choudhry, Niteesh K; Bohn, R. L.; Patrick, Amanda; Sridhar, G; Daniel, G W; Liu, Jun; Schneeweiss, Sebastian (Springer Science + Business Media, 2014)
      BACKGROUND: Methods for near-real-time monitoring of new drugs in electronic healthcare data are needed. OBJECTIVE: In a novel application, we prospectively monitored ischemic, bleeding, and mortality outcomes among patients ...

    • Patient, Physician, and Payment Predictors of Statin Adherence 

      Chan, David Chimin; Shrank, William H.; Cutler, David M.; Jan, Saira; Fischer, Michael Adam; Liu, Jun; Avorn, Jerry Lewis; Solomon, Daniel Hal; Brookhart, Alan; Choudhry, Niteesh K (American Public Health Association, 2010)
      BACKGROUND: Although many patient, physician, and payment predictors of adherence have been described, knowledge of their relative strength and overall ability to explain adherence is limited. OBJECTIVES: To measure the ...

    • Patterns of Initiation of Oral Anticoagulants in Patients with Atrial Fibrillation— Quality and Cost Implications 

      Desai, Nihar R.; Krumme, Alexis A.; Schneeweiss, Sebastian; Shrank, William; Brill, Gregory; Pezalla, Edmund J.; Spettell, Claire M.; Brennan, Troyen Anthony; Matlin, Olga S.; Avorn, Jerry Lewis; Choudhry, Niteesh Kumar (Elsevier BV, 2014)
      Background. Dabigatran, rivaroxaban, and apixaban have been approved for use in patients with atrial fibrillation based upon randomized trials demonstrating their comparable or superior efficacy and safety relative to ...

    • Paying Physicians to Prescribe Generic Drugs and Follow-On Biologics in the United States 

      Sarpatwari, Ameet; Choudhry, Niteesh K.; Avorn, Jerry; Kesselheim, Aaron S. (Public Library of Science, 2015)
      Aaron Kesselheim and colleagues examine potential strategies to promote greater prescribing of generic drugs and follow-on biologics