Browsing by Author "Ingber, Donald"

Now showing items 1-20 of 38

    • Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy 

      Adapala, Ravi K.; Thoppil, Roslin J.; Ghosh, Kaustabh; Cappelli, Holly; Dudley, Andrew C.; Paruchuri, Sailaja; Keshamouni, Venkateshwar; Klagsbrun, Michael; Meszaros, J. Gary; Chilian, William M.; Ingber, Donald E.; Thodeti, Charles K. (2016)
      Tumor vessels are characterized by abnormal morphology and hyper-permeability that together cause inefficient delivery of chemotherapeutic agents. Although VEGF has been established as a critical regulator of tumor ...

    • An Antifouling Coating That Enables Affinity-Based Electrochemical Biosensing in Complex Biological Fluids 

      Sabaté del Río, Jonathan; Henry, Olivier; Jolly, Pawan; Ingber, Donald (Springer Science and Business Media LLC, 2019-11-11)
      Affinity-based electrochemical detection in complex biological fluids could enable multiplexed point-of-care (POC) diagnostics for home healthcare; however, commercialisation of POC devices has been limited by rapid loss ...

    • Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium 

      Jain, Abhishek; van der Meer, Andries D.; Papa, Anne-Laure; Barrile, Riccardo; Lai, Angela; Schlechter, Benjamin L.; Otieno, Monicah A.; Louden, Calvert S.; Hamilton, Geraldine A.; Michelson, Alan D.; Frelinger, Andrew L.; Ingber, Donald E. (Springer US, 2016)
      The vascular endothelium and shear stress are critical determinants of physiological hemostasis and platelet function in vivo, yet current diagnostic and monitoring devices do not fully incorporate endothelial function ...

    • A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling 

      Leslie, Daniel; Waterhouse, Anna; Berthet, Julia B; Valentin, Thomas M; Watters, Alexander; Jain, Abhishek; Kim, Philseok; Hatton, Benjamin D; Nedder, Arthur; Donovan, Kathryn; Super, Elana H; Howell, Caitlin; Johnson, Christopher P; Vu, Thy L; Bolgen, Dana; Rifai, Sami; Hansen, Anne Rosenfeld; Aizenberg, Michael; Super, Michael; Aizenberg, Joanna; Ingber, Donald Elliot (Nature Publishing Group, 2014)
      Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We describe a bioinspired coating that repels blood from virtually any material by ...

    • Biomechanical forces promote blood development through prostaglandin E2 and the cAMP–PKA signaling axis 

      Diaz, Miguel F.; Li, Nan; Lee, Hyun Jung; Adamo, Luigi; Evans, Siobahn M.; Willey, Hannah E.; Arora, Natasha; Torisawa, Yu-suke; Vickers, Dwayne A.; Morris, Samantha A.; Naveiras, Olaia; Murthy, Shashi K.; Ingber, Donald E.; Daley, George Q.; García-Cardeña, Guillermo; Wenzel, Pamela L. (The Rockefeller University Press, 2015)
      Blood flow promotes emergence of definitive hematopoietic stem cells (HSCs) in the developing embryo, yet the signals generated by hemodynamic forces that influence hematopoietic potential remain poorly defined. Here we ...

    • Biophysical and Molecular Determinants in Cell Tension-Mediated Fibronectin Unfolding that Drive Fibrillogenesis 

      Gee, Elaine Pei-San (2013-02-20)
      Assembly of the extracellular matrix (ECM) protein fibronectin (FN) is a mechanical process that involves cell binding to FN through cell surface integrin receptors and application of tensional forces generated in the ...

    • Bone Marrow–on–a–Chip Replicates Hematopoietic Niche Physiology in Vitro 

      Torisawa, Yu-suke; Spina, Catherine; Mammoto, Tadanori; Mammoto, Akiko; Weaver, James C.; Tat, Tracy; Collins, James J.; Ingber, Donald Elliot (Nature Publishing Group, 2014)
      Current in vitro hematopoiesis models fail to demonstrate the cellular diversity and complex functions of living bone marrow; hence, most translational studies relevant to the hematologic system are conducted in live ...

    • A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood 

      Cartwright, Mark; Rottman, Martin; Shapiro, Nathan I.; Seiler, Benjamin; Lombardo, Patrick; Gamini, Nazita; Tomolonis, Julie; Watters, Alexander L.; Waterhouse, Anna; Leslie, Dan; Bolgen, Dana; Graveline, Amanda; Kang, Joo H.; Didar, Tohid; Dimitrakakis, Nikolaos; Cartwright, David; Super, Michael; Ingber, Donald E. (Elsevier, 2016)
      Background: Blood cultures, and molecular diagnostic tests that directly detect pathogen DNA in blood, fail to detect bloodstream infections in most infected patients. Thus, there is a need for a rapid test that can diagnose ...

    • Cellular nanoscale stiffness patterns governed by intracellular forces 

      Friedsam, Claudia; Sahin, Ozgur; Mandriota, Nicola; Jones-Molina, John; Tatem, Kathleen; Ingber, Donald (Springer Science and Business Media LLC, 2019-06-17)
      Cell stiffness measurements have led to insights into various physiological and pathological processes. Although many cellular behaviours are influenced by intracellular mechanical forces that also alter the material ...

    • A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells 

      Dolatshahi-Pirouz, Alireza; Nikkhah, Mehdi; Gaharwar, Akhilesh K.; Hashmi, Basma; Guermani, Enrico; Aliabadi, Hamed; Camci-Unal, Gulden; Ferrante, Thomas; Foss, Morten; Ingber, Donald E.; Khademhosseini, Ali (Nature Publishing Group, 2014)
      Development of three dimensional (3D) microenvironments that direct stem cell differentiation into functional cell types remains a major challenge in the field of regenerative medicine. Here, we describe a new platform to ...

    • A Complex Human-Gut Microbiome Cultured in an Anaerobic Intestine-on-a-Chip 

      Jalili-Firoozinezhad, Sasan; Gazzaniga, Francesca; Calamari, Elizabeth; Camacho, Diogo; Fadel, Cicely; Bein, Amir; Swenor, Ben; Nestor, Bret; Cronce, Michael; Levy, Oren; Gregory, Katherine; Breault, David; Cabral, Joaquim; Novak, Richard; Kasper, Dennis; Tovaglieri, Alessio; Ingber, Donald (‎Nature Research, 2019-07)
      The diverse bacterial populations that comprise the commensal microbiome of the human intestine play a central role in health and disease. A method that sustains complex microbial communities in direct contact with living ...

    • Developmentally-Inspired Engineering Of An Inductive Biomaterial for Odontogenesis 

      Hashmi, Basma (2014-06-06)
      Increasing demands for organ transplants and the depleting supply of available organs has heightened the need for alternatives to this growing problem. Tissue engineers strive to regenerate organs in the future; however ...

    • Developmentally-Inspired Shrink-Wrap Polymers for Mechanical Induction of Tissue Differentiation 

      Hashmi, Basma; Zarzar, Lauren D.; Mammoto, Tadanori; Mammoto, Akiko; Jiang, Amanda; Aizenberg, Joanna; Ingber, Donald Elliot (Wiley, 2014)
      A biologically inspired thermoresponsive polymer has been developed that mechanically induces tooth differentiation in vitro and in vivo by promoting mesenchymal cell compaction as seen in each pore of the scaffold. This ...

    • Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip 

      Herland, Anna; van der Meer, Andries D.; FitzGerald, Edward A.; Park, Tae-Eun; Sleeboom, Jelle J. F.; Ingber, Donald E. (Public Library of Science, 2016)
      Neurovascular inflammation is a major contributor to many neurological disorders, but modeling these processes in vitro has proven to be difficult. Here, we microengineered a three-dimensional (3D) model of the human ...

    • Epoxyeicosanoids Promote Organ and Tissue Regeneration 

      Panigrahy, Dipak; Kalish, Brian T.; Huang, Sui; Bielenberg, Diane; Le, Hau D.; Yang, Jun; Edin, Matthew L.; Lee, Craig R.; Benny, Ofra; Mudge, Dayna K.; Butterfield, Catherine E.; Mammoto, Akiko; Mammoto, Tadanori; Inceoglu, Bora; Jenkins, Roger L.; Simpson, Mary A.; Akino, Tomoshige; Lih, Fred B.; Tomer, Kenneth B.; Ingber, Donald; Hammock, Bruce D.; Falck, John R.; Manthati, Vijaya L.; Kaipainen, Arja; D'Amore, Patricia; Puder, Mark; Zeldin, Darryl C.; Kieran, Mark W. (National Academy of Sciences, 2013-07-29)
      Epoxyeicosatrienoic acids (EETs), lipid mediators produced by cytochrome P450 epoxygenases, regulate inflammation, angiogenesis, and vascular tone. Despite pleiotropic effects on cells, the role of these epoxyeicosanoids ...

    • Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice 

      Panigrahy, Dipak; Edin, Matthew L.; Lee, Craig R.; Huang, Sui; Bielenberg, Diane; Butterfield, Catherine E.; Barnés, Carmen M.; Mammoto, Akiko; Mammoto, Tadanori; Luria, Ayala; Benny, Ofra; Chaponis, Deviney M.; Dudley, Andrew C.; Greene, Emily R.; Vergilio, Jo-Anne; Pietramaggiori, Giorgio; Scherer-Pietramaggiori, Sandra S.; Short, Sarah M.; Seth, Meetu; Lih, Fred B.; Tomer, Kenneth B.; Yang, Jun; Schwendener, Reto A.; Hammock, Bruce D.; Falck, John R.; Manthati, Vijaya L.; Ingber, Donald Elliot; Kaipainen, Arja; D'Amore, Patricia Ann; Kieran, Mark W.; Zeldin, Darryl C. (American Society for Clinical Investigation, 2012)
      Epoxyeicosatrienoic acids (EETs) are small molecules produced by cytochrome P450 epoxygenases. They are lipid mediators that act as autocrine or paracrine factors to regulate inflammation and vascular tone. As a result, ...

    • Extracellular Matrix as a Key Mediator of Mammary Tumor Cell Normalization 

      Bischof, Ashley Gibbs (2013-10-08)
      Some epithelial cancers can be induced to revert to quiescent differentiated tissues when combined with embryonic mesenchyme; however, the mechanism of this induction is unknown. This dissertation is based on the hypothesis ...

    • Fibronectin Unfolding Revisited: Modeling Cell Traction-Mediated Unfolding of the Tenth Type-III Repeat 

      Gee, Elaine Pei-San; Ingber, Donald Elliott; Stultz, Collin Melveton (Public Library of Science, 2008)
      Fibronectin polymerization is essential for the development and repair of the extracellular matrix. Consequently, deciphering the mechanism of fibronectin fibril formation is of immense interest. Fibronectin fibrillogenesis ...

    • High-Betweenness Proteins in the Yeast Protein Interaction Network 

      Joy, Maliackal Poulo; Brock, Amy Monique Lepre; Ingber, Donald Elliott; Huang, Sui (Hindawi Publishing Corporation, 2005)
      Structural features found in biomolecular networks that are absent in random networks produced by simple algorithms can provide insight into the function and evolution of cell regulatory networks. Here we analyze “betweenness” ...

    • How Changes in Extracellular Matrix Mechanics and Gene Expression Variability Might Combine to Drive Cancer Progression 

      Werfel, Justin; Krause, Silva; Bischof, Ashley G.; Mannix, Robert J.; Tobin, Heather; Bar-Yam, Yaneer; Bellin, Robert M.; Ingber, Donald E. (Public Library of Science, 2013)
      Changes in extracellular matrix (ECM) structure or mechanics can actively drive cancer progression; however, the underlying mechanism remains unknown. Here we explore whether this process could be mediated by changes in ...