Browsing by Author "Mammoto, Akiko"

Now showing items 1-9 of 9

    • Bone Marrow–on–a–Chip Replicates Hematopoietic Niche Physiology in Vitro 

      Torisawa, Yu-suke; Spina, Catherine; Mammoto, Tadanori; Mammoto, Akiko; Weaver, James C.; Tat, Tracy; Collins, James J.; Ingber, Donald Elliot (Nature Publishing Group, 2014)
      Current in vitro hematopoiesis models fail to demonstrate the cellular diversity and complex functions of living bone marrow; hence, most translational studies relevant to the hematologic system are conducted in live ...

    • LRP5 Regulates Development of Lung Microvessels and Alveoli through the Angiopoietin-Tie2 Pathway 

      Mammoto, Tadanori; Jiang, Amanda Rose; Jiang, Elizabeth Qingyu; Mammoto, Akiko; Chen, Jing; Smith, Lois Elaine Hodgson; Ingber, Donald Elliott (Public Library of Science, 2012)
      Angiogenesis is crucial for lung development. Although there has been considerable exploration, the mechanism by which lung vascular and alveolar formation is controlled is still not completely understood. Here we show ...

    • Matrix Elasticity of Void-Forming Hydrogels Controls Transplanted Stem Cell-Mediated Bone Formation 

      Huebsch, Nathaniel; Lippens, Evi; Lee, Kangwon; Mehta, Manav; Koshy, Sandeep T; Darnell, Max C; Desai, Rajiv; Madl, Christopher M.; Xu, Maria; Zhao, Xuanhe; Chaudhuri, Ovijit; Verbeke, Catia; Kim, Woo Seob; Alim, Karen; Mammoto, Akiko; Ingber, Donald E.; Duda, Georg N; Mooney, David J. (2015)
      The effectiveness of stem-cell therapies has been hampered by cell death and limited control over fate1. These problems can be partially circumvented by using macroporous biomaterials that improve the survival of transplanted ...

    • A Mechanosensitive Transcriptional Mechanism That Controls Angiogenesis 

      Mammoto, Akiko; Connor, Kip; Mammoto, Tadanori; Yung, Chong W.; Huh, Dongeun; Aderman, Christopher Michael; Mostoslavsky, Gustavo; Smith, Lois Elaine Hodgson; Ingber, Donald Elliott (Nature Publishing Group, 2009)
      Angiogenesis is controlled by physical interactions between cells and extracellular matrix as well as soluble angiogenic factors, such as VEGF. However, the mechanism by which mechanical signals integrate with other ...

    • Multizone Paper Platform for 3D Cell Cultures 

      Derda, Ratmir; Tang, Sindy K. Y.; Laromaine, Anna; Mosadegh, Bobak; Hong, Estrella; Mwangi, Martin; Mammoto, Akiko; Ingber, Donald Elliot; Whitesides, George McClelland (Public Library of Science (PLoS), 2011)
      In vitro 3D culture is an important model for tissues in vivo. Cells in different locations of 3D tissues are physiologically different, because they are exposed to different concentrations of oxygen, nutrients, and signaling ...

    • Twist1 Controls Lung Vascular Permeability and Endotoxin-Induced Pulmonary Edema by Altering Tie2 Expression 

      Mammoto, Tadanori; Jiang, Elisabeth; Jiang, Amanda; Lu, Yongbo; Juan, Aimee M.; Chen, Jing; Mammoto, Akiko (Public Library of Science, 2013)
      Tight regulation of vascular permeability is necessary for normal development and deregulated vascular barrier function contributes to the pathogenesis of various diseases, including acute respiratory distress syndrome, ...

    • TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis 

      Mahmoud, Marwa M.; Kim, Hyejeong Rosemary; Xing, Rouyu; Hsiao, Sarah; Mammoto, Akiko; Chen, Jing; Serbanovic-Canic, Jovana; Feng, Shuang; Bowden, Neil P.; Maguire, Richard; Ariaans, Markus; Francis, Sheila E.; Weinberg, Peter D.; van der Heiden, Kim; Jones, Elizabeth A.; Chico, Timothy J.A.; Ridger, Victoria; Evans, Paul C. (Lippincott Williams & Wilkins, 2016)
      Rationale: Blood flow–induced shear stress controls endothelial cell (EC) physiology during atherosclerosis via transcriptional mechanisms that are incompletely understood. The mechanosensitive transcription factor TWIST ...

    • VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells 

      Yoshida, Ayumi; Shimizu, Akio; Asano, Hirotsugu; Kadonosono, Tetsuya; Kondoh, Shinae Kizaka; Geretti, Elena; Mammoto, Akiko; Klagsbrun, Michael; Seo, Misuzu Kurokawa (The Company of Biologists, 2015)
      ABSTRACT Neuropilin-1 (NRP1) has been identified as a VEGF-A receptor. DJM-1, a human skin cancer cell line, expresses endogenous VEGF-A and NRP1. In the present study, the RNA interference of VEGF-A or NRP1 suppressed ...

    • Wnt Signaling Mediates Pathological Vascular Growth in Proliferative Retinopathy Clinical Perspective 

      Chen, Jing; Stahl, Andreas; Krah, Nathan M.; Seaward, Molly R.; Dennison, Roberta; Sapieha, Przemyslaw; Hua, Jing; Hatton, Colman J.; Juan, Aimee M.; Aderman, Christopher; Willett, Keirnan L.; Guerin, Karen I.; Mammoto, Akiko; Campbell, Matthew; Smith, Lois Elaine Hodgson (Ovid Technologies (Wolters Kluwer Health), 2011)
      BACKGROUND: Ischemic proliferative retinopathy, characterized by pathological retinal neovascularization, is a major cause of blindness in working-age adults and children. Defining the molecular pathways distinguishing ...