Browsing by Author "Nibert, Max"
Now showing items 1-9 of 9
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A +1 ribosomal frameshifting motif prevalent among plant amalgaviruses
Nibert, Max L.; Pyle, Jesse D.; Firth, Andrew E. (Academic Press, 2016)Sequence accessions attributable to novel plant amalgaviruses have been found in the Transcriptome Shotgun Assembly database. Sixteen accessions, derived from 12 different plant species, appear to encompass the complete ... -
Bioinformatics of Recent Aqua- and Orthoreovirus Isolates from Fish: Evolutionary Gain or Loss of FAST and Fiber Proteins and Taxonomic Implications
Nibert, Max L.; Duncan, Roy (Public Library of Science, 2013)Family Reoviridae, subfamily Spinareovirinae, includes nine current genera. Two of these genera, Aquareovirus and Orthoreovirus, comprise members that are closely related and consistently share nine homologous proteins. ... -
Comparisons of the M1 Genome Segments and Encoded μ2 Proteins of Different Reovirus Isolates
Yin, Peng; Keirstead, Natalie D; Broering, Teresa J; Arnold, Michelle M; Parker, John SL; Nibert, Max Lee; Coombs, Kevin M (BioMed Central, 2004)Background: The reovirus M1 genome segment encodes the μ2 protein, a structurally minor component of the viral core, which has been identified as a transcriptase cofactor, nucleoside and RNA triphosphatase, and microtubule-binding ... -
Endobiont Viruses Sensed by the Human Host – Beyond Conventional Antiparasitic Therapy
Fichorova, Raina N.; Lee, Yujin; Yamamoto, Hidemi; Takagi, Yuko; Hayes, Gary R.; Goodman, Russell P.; Chepa-Lotrea, Xenia; Buck, Olivia R.; Murray, Ryan; Kula, Tomasz; Beach, David H.; Singh, Bibhuti N.; Nibert, Max L. (Public Library of Science, 2012)Wide-spread protozoan parasites carry endosymbiotic dsRNA viruses with uncharted implications to the human host. Among them, Trichomonas vaginalis, a parasite adapted to the human genitourinary tract, infects globally ∼250 ... -
Investigating Host Protein Function and Developing Assays for Influenza Virus Infection
Sun, Eileen (2015-04-08)With eight genomic segments encoding at least thirteen proteins, influenza virus can subvert a cell into a virus-producing factory. To study influenza infection, I utilize versatile fluorescent-based technologies to ... -
Mechanism for Coordinated RNA Packaging and Genome Replication by Rotavirus Polymerase VP1
Lu, Xiaohui; McDonald, Sarah M.; Tortorici, M. Alejandra; Tao, Yizhi Jane; Carpio, Rodrigo Vasquez-Del; Nibert, Max; Patton, John T.; Harrison, Stephen (Elsevier (Cell Press), 2008)Rotavirus RNA-dependent RNA polymerase, VP1, catalyzes RNA synthesis within a subviral particle. This activity depends on core shell protein VP2. A conserved sequence at the 3′ end of plusstrand RNA templates is important ... -
Structure of a Protozoan Virus from the Human Genitourinary Parasite Trichomonas vaginalis
Parent, Kristin N.; Takagi, Yuko; Cardone, Giovanni; Olson, Norman H.; Ericsson, Maria; Yang, May; Lee, Yujin; Asara, John M; Fichorova, Raina Nakova; Baker, Timothy S.; Nibert, Max Lee (American Society of Microbiology, 2013)The flagellated protozoan Trichomonas vaginalis is an obligate human genitourinary parasite and the most frequent cause of sexually transmitted disease worldwide. Most clinical isolates of T. vaginalis are persistently ... -
Three-dimensional Structure of Victorivirus HvV190S Suggests Coat Proteins in Most Totiviruses Share a Conserved Core
Dunn, Sarah E.; Li, Hua; Cardone, Giovanni; Nibert, Max Lee; Ghabrial, Said A.; Baker, Timothy S. (Public Library of Science, 2013)Double-stranded (ds)RNA fungal viruses are currently assigned to six different families. Those from the family Totiviridae are characterized by nonsegmented genomes and single-layer capsids, 300–450 Å in diameter. ... -
The Villain Team-Up or how Trichomonas vaginalis and bacterial vaginosis alter innate immunity in concert
Fichorova, Raina N; Buck, Olivia R; Yamamoto, Hidemi S; Fashemi, Titilayo; Dawood, Hassan Y; Fashemi, Bisiayo; Hayes, Gary R; Beach, David H; Takagi, Yuko; Delaney, Mary L; Nibert, Max L; Singh, Bibhuti N; Onderdonk, Andrew B (BMJ Publishing Group, 2013)Objectives: Complex interactions of vaginal microorganisms with the genital tract epithelium shape mucosal innate immunity, which holds the key to sexual and reproductive health. Bacterial vaginosis (BV), a microbiome-disturbance ...