Browsing by Author "Iacob, Roxana E."

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    • Novel Mutant-Selective EGFR Kinase Inhibitors Against EGFR T790M 

      Zhou, Wenjun; Ercan, Dalia; Chen, Liang; Yun, Cai-Hong; Li, Danan; Capelletti, Marzia; Cortot, Alexis; Chirieac, Lucian; Iacob, Roxana E.; Padera, Robert; Engen, John R.; Wong, Kwok-Kin; Eck, Michael; Gray, Nathanael S.; Janne, Pasi (Springer Science and Business Media LLC, 2009-12-24)
      The clinical efficacy of epidermal growth factor receptor (EGFR) kinase inhibitors in EGFR-mutant non-small-cell lung cancer (NSCLC) is limited by the development of drug-resistance mutations, including the gatekeeper T790M ...