Browsing by Author "Ba, Zhaoqing"

Now showing items 1-4 of 4

    • CTCF Orchestrates Long-Range Cohesin-Driven V(D)J Recombinational Scanning 

      Ba, Zhaoqing; Lou, Jiangman; Ye, Adam Yongxin; Dring, Edward; Lin, Sherry G.; Jain, Suvi; Kyritsis, Nia; Kieffer-Kwon, Kyong-Rim; Casellas, Rafael; Alt, Frederick (Springer Nature Publishing Group, 2020-07-27)
      RAG endonuclease initiates V(D)J recombination in progenitor (pro)-B cells1. Upon binding a recombination center (RC)-based JH, RAG scans upstream chromatin via loop extrusion, potentially mediated by cohesin, to locate ...

    • The Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination 

      Zhang, Yu; Zhang, Xuefei; Ba, Zhaoqing; Liang, Zhuoyi; Hu, Hongli; Lou, Jiangman; Kyritsis, Nia; Zurita, Jeffrey; Shamim, Muhammad S.; Presser Aiden, Aviva; Lieberman Aiden, Erez; Alt, Frederick W.; Dring, Edward (Springer Science and Business Media LLC, 2019-09)
      RAG endonuclease initiates IgH locus (Igh) V(D)J assembly in progenitor (pro)-B cells by joining Ds to JHs, before joining upstream VHs to DJH intermediates1. In mouse pro-B cells, the CTCF-binding element (CBE)-anchored ...

    • Fundamental Roles of Chromatin Loop Extrusion in Antibody Class Switching 

      Zhang, Xuefei; Zhang, Yu; Ba, Zhaoqing; Kyritsis, Nia; Alt, Frederick; Casellas, Rafael (Springer Science and Business Media LLC, 2019-10-30)
      Antibody class switch recombination (CSR) in B lymphocytes replaces immunoglobulin heavy chain locus (Igh) Cμ constant region exons (CHs) with one of six CHs lying 100–200 kb downstream1. Each CH is flanked upstream by an ...

    • Loop Extrusion Mediates Physiological IgH Locus Contraction For RAG Scanning 

      Dai, Hai-Qiang; Hu, Hongli; Lou, Jiangman; Ye, Adam Yongxin; Zhang, Xuefei; Zhang, Yiwen; Zhao, Lijuan; Yoon, Hye; Ba, Zhaoqing; Chapdelaine-Williams, Aimee M.; Kyritsis, Nia; Chen, Huan; Johnson, Kerstin; Lin, Sherry; Conte, Andrea; Casellas, Rafael; Lee, Cheng-Sheng; Alt, Frederick (Springer Science and Business Media LLC, 2021-01-13)
      RAG endonuclease initiates IgH V(D)J recombination in pro-B cells by binding a JH-recombination signal sequence (RSS) within a recombination center (RC) and then linearly scanning upstream chromatin, presented by ...