Browsing by Author "Shrank, William"

Now showing items 1-12 of 12

    • Association Between Trajectories of Statin Adherence and Subsequent Cardiovascular Events 

      Franklin, Jessica Myers; Krumme, Alexis Ann; Tong, Angela Y.; Shrank, William; Matlin, Olga S.; Brennan, Troyen Anthony; Choudhry, Niteesh (Wiley-Blackwell, 2015)
      PURPOSE: Trajectory models have been shown to (1) identify groups of patients with similar patterns of medication filling behavior and (2) summarize the trajectory, the average adherence in each group over time. However, ...

    • Comparative Effectiveness of Generic and Brand-Name Statins on Patient Outcomes 

      Gagne, Joshua J; Choudhry, Niteesh Kumar; Kesselheim, Aaron Seth; Polinski, Jennifer Milan; Hutchins, David; Matlin, Olga S.; Brennan, Troyen Anthony; Avorn, Jerry Lewis; Shrank, William (American College of Physicians, 2014)
      Background: Statins are effective in preventing cardiovascular events, but patients do not fully adhere to them. Objective: To determine whether patients are more adherent to generic statins versus brand-name statins ...

    • Comparative effectiveness of generic versus brand-name antiepileptic medications 

      Gagne, Joshua J; Kesselheim, Aaron Seth; Choudhry, Niteesh Kumar; Polinski, Jennifer Milan; Hutchins, David; Matlin, Olga S.; Brennan, Troyen Anthony; Avorn, Jerry Lewis; Shrank, William (Elsevier BV, 2015)
      OBJECTIVE: The objective of this study was to compare treatment persistence and rates of seizure-related events in patients who initiate antiepileptic drug (AED) therapy with a generic versus a brand-name product. METHODS: ...

    • Despite increased use and sales of statins in India, per capita prescription rates remain far below high-income countries 

      Choudhry, Niteesh K; Dugani, Sagar; Shrank, William; Polinski, Jennifer Milan; Stark, Christina E.; Gupta, Rajeev; Prabhakaran, Dorairaj; Brill, Gregory; Jha, Prabhat (Project HOPE, 2014)
      Statin use has increased substantially in North America and Europe, with resultant reductions in cardiovascular mortality. However, little is known about statin use in lower-income countries. India is of interest because ...

    • Equity in the Receipt of Oseltamivir in the United States During the H1N1 Pandemic 

      Franklin, Jessica Myers; Choudhry, Niteesh Kumar; Uscher-Pines, Lori; Brill, Gregory; Matlin, Olga S.; Fischer, Michael Adam; Schneeweiss, Sebastian; Avorn, Jerry Lewis; Brennan, Troyen Anthony; Shrank, William (American Public Health Association, 2014)
      Objectives. We assessed the relationship between individual characteristics and receipt of oseltamivir (Tamiflu) in the United States during the H1N1 pandemic and other flu seasons. Methods. In a cohort of individuals ...

    • Group-based Trajectory Models: A New Approach to Classifying and Predicting Long-Term Medication Adherence 

      Franklin, Jessica Myers; Shrank, William; Pakes, Juliana; Sanfélix-Gimeno, Gabriel; Matlin, Olga S.; Brennan, Troyen Anthony; Choudhry, Niteesh Kumar (Ovid Technologies (Wolters Kluwer Health), 2013)
      BACKGROUND: Classifying medication adherence is important for efficiently targeting adherence improvement interventions. The purpose of this study was to evaluate the use of a novel method, group-based trajectory models, ...

    • Interventions to Improve Adherence and Persistence With Osteoporosis Medications: A Systematic Literature Review 

      Gleeson, T.; Iversen, Maura Daly; Avorn, Jerry Lewis; Brookhart, A. M.; Katz, Jeffrey Neil; Losina, Elena; May, F.; Patrick, A. R.; Shrank, W; Solomon, Daniel Hal; Solomon, Daniel Hal (Springer Science + Business Media, 2009-06-05)
      Summary: Adherence and persistence with osteoporosis medications are poor. We conducted a systematic literature review of interventions to improve adherence and persistence with osteoporosis medications. Seven studies met ...

    • Medication Adherence and Healthcare Disparities: Impact of Statin Co-Payment Reduction 

      Lewey, Jennifer; Shrank, William; Avorn, Jerry Lewis; Liu, Jun; Choudhry, Niteesh Kumar (Managed Care & Healthcare Communications, 2015)
      Objectives: Minority patients have lower rates of cardiovascularmedication adherence, which may be amenable to co-payment reductions.Our objective was to evaluate the effect of race on adherencechanges following a statin ...

    • Patient, Physician, and Payment Predictors of Statin Adherence 

      Chan, David Chimin; Shrank, William H.; Cutler, David M.; Jan, Saira; Fischer, Michael Adam; Liu, Jun; Avorn, Jerry Lewis; Solomon, Daniel Hal; Brookhart, Alan; Choudhry, Niteesh K (American Public Health Association, 2010)
      BACKGROUND: Although many patient, physician, and payment predictors of adherence have been described, knowledge of their relative strength and overall ability to explain adherence is limited. OBJECTIVES: To measure the ...

    • Patterns of Initiation of Oral Anticoagulants in Patients with Atrial Fibrillation— Quality and Cost Implications 

      Desai, Nihar R.; Krumme, Alexis A.; Schneeweiss, Sebastian; Shrank, William; Brill, Gregory; Pezalla, Edmund J.; Spettell, Claire M.; Brennan, Troyen Anthony; Matlin, Olga S.; Avorn, Jerry Lewis; Choudhry, Niteesh Kumar (Elsevier BV, 2014)
      Background. Dabigatran, rivaroxaban, and apixaban have been approved for use in patients with atrial fibrillation based upon randomized trials demonstrating their comparable or superior efficacy and safety relative to ...

    • Time series analyses of the effect of FDA communications on use of prescription weight loss medications 

      Block, Jason Perry; Choudhry, Niteesh Kumar; Carpenter, Daniel Paul; Fischer, Michael Adam; Brennan, Troyen Anthony; Tong, A. Y.; Matlin, O. S.; Shrank, W (Wiley-Blackwell, 2014)
      OBJECTIVE: To determine the impact of FDA safety communications regarding the weight loss medications sibutramine and orlistat. METHODS: The 2008 to 2011 pharmacy claims data from CVS Caremark were used to determine the ...

    • Trends in Insulin Initiation and Treatment Intensification Among Patients with Type 2 Diabetes 

      Patrick, Amanda; Fischer, Michael Adam; Choudhry, Niteesh Kumar; Shrank, W; Seeger, John; Liu, Jun; Avorn, Jerry Lewis; Polinski, Jennifer Milan (Springer Science + Business Media, 2014)
      BACKGROUND: Many patients with type 2 diabetes eventually require insulin, yet little is known about the patterns and quality of pharmacologic care received following insulin initiation. Guidelines from the American Diabetes ...