Browsing by Author "Leffler, Daniel"

Now showing items 1-10 of 10

    • Acid Suppression Therapy Does Not Predispose to Clostridium difficile Infection: The Case of the Potential Bias 

      Novack, Lena; Kogan, Slava; Gimpelevich, Larisa; Howell, Michael; Borer, Abraham; Kelly, Ciarán P.; Leffler, Daniel A.; Novack, Victor (Public Library of Science, 2014)
      Objective: An adverse effect of acid-suppression medications on the occurrence of Clostridium difficile infection (CDI) has been a common finding of many, but not all studies. We hypothesized that association between ...

    • Attitudes to Mesalamine Questionnaire: A Novel Tool to Predict Mesalamine Nonadherence in Patients with IBD 

      Moss, Alan C; Lillis, Yvonne; Edwards George, Jessica B.; Choudhry, Niteesh Kumar; Berg, Anders Hayden; Cheifetz, Adam S.; Horowitz, Gary Leigh; Leffler, Daniel Alexander (Springer Nature, 2014)
      OBJECTIVES: Poor adherence to mesalamine is common and driven by a combination of lifestyle and behavioral factors, as well as health beliefs. We sought to develop a valid tool to identify barriers to patient adherence and ...

    • Cancer in first-degree relatives of people with celiac disease 

      Emilsson, Louise; Murray, Joseph A.; Leffler, Daniel A.; Ludvigsson, Jonas F. (Wolters Kluwer Health, 2016)
      Abstract Background: Celiac disease (CD) has been linked to cancer, especially lymphoproliferative malignancy (LPM). Earlier research has shown that first-degree relatives (FDRs) to individuals with CD are at increased ...

    • Clostridium difficile outbreaks: Prevention and treatment strategies 

      Martinez, Fernando J; Leffler, Daniel Alexander; Kelly, Ciaran Patrick (Dove Medical Press, 2012)
      The incidence and severity of Clostridium difficile infection (CDI) have increased dramatically over the past decade. Its treatment, however, has largely remained the same with the exception of oral vancomycin use as a ...

    • Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology 

      Ludvigsson, Jonas F; Bai, Julio C; Biagi, Federico; Card, Timothy R; Ciacci, Carolina; Ciclitira, Paul J; Green, Peter H R; Hadjivassiliou, Marios; Holdoway, Anne; van Heel, David A; Kaukinen, Katri; Leffler, Daniel A; Leonard, Jonathan N; Lundin, Knut E A; McGough, Norma; Davidson, Mike; Murray, Joseph A; Swift, Gillian L; Walker, Marjorie M; Zingone, Fabiana; Sanders, David S (BMJ Publishing Group, 2014)
      A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac ...

    • Exposure sources, amounts and time course of gluten ingestion and excretion in patients with coeliac disease on a gluten‐free diet 

      Silvester, Jocelyn; Comino, Isabel; Rigaux, Lisa N.; Segura, Veronica; Green, Kathy H.; Cebolla, Angel; Weiten, Dayna; Dominguez, Remedios; Leffler, Daniel; Leon, Francisco; Bernstein, Charles N.; Graff, Lesley A.; Kelly, Ciaran; Sousa, Carolina; Duerksen, Donald R. (Wiley, 2020-11)
      Background A major deficit in understanding and improving treatment in coeliac disease (CD) is the lack of empiric data on real world gluten exposure. Aims To estimate gluten exposure on a gluten‐free diet (GFD) using ...

    • A Multi-Center Prospective Derivation and Validation of a Clinical Prediction Tool for Severe Clostridium difficile Infection 

      Na, Xi; Martin, Alan J.; Sethi, Saurabh; Kyne, Lorraine; Garey, Kevin W.; Flores, Sarah W.; Hu, Mary; Shah, Dhara N.; Shields, Kelsey; Leffler, Daniel A.; Kelly, Ciarán P. (Public Library of Science, 2015)
      Background and Aims Prediction of severe clinical outcomes in Clostridium difficile infection (CDI) is important to inform management decisions for optimum patient care. Currently, treatment recommendations for CDI vary ...

    • An open-access endoscopy screen correctly and safely identifies patients for conscious sedation 

      Kothari, Darshan; Feuerstein, Joseph D.; Moss, Laureen; D’Souza, Julie; Montanaro, Kerri; Leffler, Daniel A.; Sheth, Sunil G. (Oxford University Press, 2016)
      Background and aims: Open-access scheduling is highly utilized for facilitating generally low-risk endoscopies. Preprocedural screening addresses sedation requirements; however, procedural safety may be compromised if ...

    • A Randomized, Double-Blind Study of Larazotide Acetate to Prevent the Activation of Celiac Disease During Gluten Challenge 

      Leffler, Daniel Alexander; Kelly, Ciaran Patrick; Abdallah, H Z; Colatrella, A M; Harris, L A; Leon, F; Arterburn, L A; Paterson, B M; Lan, Z H; Murray, J A (Nature Publishing Group, 2012)
      OBJECTIVES: In patients with celiac disease, enteropathy is caused by the entry of gluten peptides into the lamina propria of the intestine, in which their immunogenicity is potentiated by tissue transglutaminase (tTG) and ...

    • Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4 

      Junker, Yvonne; Zeissig, Sebastian; Kim, Seong-Jun; Barisani, Donatella; Wieser, Herbert; Leffler, Daniel A.; Zevallos, Victor; Libermann, Towia A.; Dillon, Simon; Freitag, Tobias L.; Kelly, Ciaran P.; Schuppan, Detlef (The Rockefeller University Press, 2012)
      Ingestion of wheat, barley, or rye triggers small intestinal inflammation in patients with celiac disease. Specifically, the storage proteins of these cereals (gluten) elicit an adaptive Th1-mediated immune response in ...