Browsing by Author "Mammoto, Tadanori"

Now showing items 1-5 of 5

    • Bone Marrow–on–a–Chip Replicates Hematopoietic Niche Physiology in Vitro 

      Torisawa, Yu-suke; Spina, Catherine; Mammoto, Tadanori; Mammoto, Akiko; Weaver, James C.; Tat, Tracy; Collins, James J.; Ingber, Donald Elliot (Nature Publishing Group, 2014)
      Current in vitro hematopoiesis models fail to demonstrate the cellular diversity and complex functions of living bone marrow; hence, most translational studies relevant to the hematologic system are conducted in live ...

    • Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans 

      Parikh, Samir Mukund; Mammoto, Tadanori; Schultz, Aylit; Yuan, Hai-Tao; Christiani, David C.; Karumanchi, Subbian Ananth; Sukhatme, Vikas Pandurang (Public Library of Science, 2006)
      Background: Acute respiratory distress syndrome (ARDS) is a devastating complication of numerous underlying conditions, most notably sepsis. Although pathologic vascular leak has been implicated in the pathogenesis of ARDS ...

    • LRP5 Regulates Development of Lung Microvessels and Alveoli through the Angiopoietin-Tie2 Pathway 

      Mammoto, Tadanori; Jiang, Amanda Rose; Jiang, Elizabeth Qingyu; Mammoto, Akiko; Chen, Jing; Smith, Lois Elaine Hodgson; Ingber, Donald Elliott (Public Library of Science, 2012)
      Angiogenesis is crucial for lung development. Although there has been considerable exploration, the mechanism by which lung vascular and alveolar formation is controlled is still not completely understood. Here we show ...

    • A Mechanosensitive Transcriptional Mechanism That Controls Angiogenesis 

      Mammoto, Akiko; Connor, Kip; Mammoto, Tadanori; Yung, Chong W.; Huh, Dongeun; Aderman, Christopher Michael; Mostoslavsky, Gustavo; Smith, Lois Elaine Hodgson; Ingber, Donald Elliott (Nature Publishing Group, 2009)
      Angiogenesis is controlled by physical interactions between cells and extracellular matrix as well as soluble angiogenic factors, such as VEGF. However, the mechanism by which mechanical signals integrate with other ...

    • Twist1 Controls Lung Vascular Permeability and Endotoxin-Induced Pulmonary Edema by Altering Tie2 Expression 

      Mammoto, Tadanori; Jiang, Elisabeth; Jiang, Amanda; Lu, Yongbo; Juan, Aimee M.; Chen, Jing; Mammoto, Akiko (Public Library of Science, 2013)
      Tight regulation of vascular permeability is necessary for normal development and deregulated vascular barrier function contributes to the pathogenesis of various diseases, including acute respiratory distress syndrome, ...