Browsing by Author "Cohen, Bruce"

Now showing items 1-10 of 10

    • Cognitive remediation versus active computer control in bipolar disorder with psychosis: study protocol for a randomized controlled trial 

      Lewandowski, Kathryn Eve; Sperry, Sarah H.; Ongur, Dost; Cohen, Bruce M.; Norris, Lesley A.; Keshavan, Matcheri S. (BioMed Central, 2016)
      Background: Cognitive dysfunction is a major feature of bipolar disorder with psychosis and is strongly associated with functional outcomes. Computer-based cognitive remediation has shown promise in improving cognition in ...

    • Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons 

      Yoshimizu, Takao; Pan, Jen Q.; Mungenast, Alison E.; Madison, Jon M.; Su, Susan; Ketterman, Josh; Ongur, Dost; McPhie, Donna; Cohen, Bruce; Perlis, Roy; Tsai, Li-Huei (2014)
      Psychiatric disorders have clear heritable risk. Several large-scale genome-wide association studies have revealed a strong association between susceptibility for psychiatric disorders, including bipolar disease, schizophrenia, ...

    • A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug Target 

      Saur, Taixiang; DeMarco, Sarah E.; Ortiz, Angelica; Sliwoski, Gregory R.; Hao, Limin; Wang, Xin; Cohen, Bruce Michael; Buttner, Edgar (Ned) A. (Public Library of Science, 2013)
      We report a genome-wide RNA interference (RNAi) screen for Suppressors of Clozapine-induced Larval Arrest (scla genes) in Caenorhabditis elegans, the first genetic suppressor screen for antipsychotic drug (APD) targets in ...

    • Kappa‐opioid receptors differentially regulate low and high levels of ethanol intake in female mice 

      Van't Veer, Ashlee; Smith, Karen L.; Cohen, Bruce M.; Carlezon, William A.; Bechtholt, Anita J. (John Wiley and Sons Inc., 2016)
      Abstract Introduction: Studies in laboratory animals and humans indicate that endogenous opioids play an important role in regulating the rewarding value of various drugs, including ethanol (EtOH). Indeed, opioid antagonists ...

    • Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity 

      Munro, Thomas A; Berry, Loren M; Carroll, F Ivy; Zhao, Zhiyang; Carlezon, William A.; Cohen, Bruce Michael; Van't Veer, Ashlee Victoria; Beguin, Cecile Andree (BioMed Central, 2012)
      Background: Nor-BNI, GNTI and JDTic induce κ opioid antagonism that is delayed by hours and can persist for months. Other effects are transient. It has been proposed that these drugs may be slowly absorbed or distributed, ...

    • A Longitudinal Pilot Proton MRS Investigation of the Manic and Euthymic States of Bipolar Disorder 

      Brady, Roscoe Owen; Cooper, Anne; Jensen, John Eric; Tandon, Neeraj; Cohen, Bruce Michael; Renshaw, Perry Franklin; Keshavan, Matcheri S; Öngür, Dost (Nature Publishing Group, 2012)
      Several lines of evidence implicate dysfunction in brain energy production as a key component of bipolar disorder. In particular, elevated brain lactate levels observed in this condition suggest a shift from aerobic to ...

    • Pathway Analyses Implicate Glial Cells in Schizophrenia 

      Duncan, Laramie E.; Holmans, Peter A.; Lee, Phil H.; O'Dushlaine, Colm T.; Kirby, Andrew W.; Smoller, Jordan W.; Öngür, Dost; Cohen, Bruce M. (Public Library of Science, 2014)
      Background: The quest to understand the neurobiology of schizophrenia and bipolar disorder is ongoing with multiple lines of evidence indicating abnormalities of glia, mitochondria, and glutamate in both disorders. Despite ...

    • Salvinorin B Meth­oxy­methyl Ether 

      Munro, Thomas A.; Ho, Douglas M.; Cohen, Bruce Michael (International Union of Crystallography, 2012)
      The title compound [MOM-SalB; systematic name: methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-fur­yl)-9-meth­oxy­meth­oxy-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octa­hydro-1H-benzo[f]isochromene-7-carboxyl­ate], ...

    • Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters 

      Munro, Thomas A.; Huang, Xi-Ping; Inglese, Carmela; Perrone, Maria Grazia; Van't Veer, Ashlee; Carroll, F. Ivy; Béguin, Cécile; Carlezon, William A.; Colabufo, Nicola A.; Cohen, Bruce M.; Roth, Bryan L. (Public Library of Science, 2013)
      Background: Nor-BNI, GNTI and JDTic induce selective κ opioid antagonism that is delayed and extremely prolonged, but some other effects are of rapid onset and brief duration. The transient effects of these compounds differ, ...

    • Sprouty2 in the Dorsal Hippocampus Regulates Neurogenesis and Stress Responsiveness in Rats 

      Dow, Antonia L.; Lin, Tiffany V.; Chartoff, Elena H.; Potter, David; McPhie, Donna L.; Van’t Veer, Ashlee V.; Knoll, Allison T.; Lee, Kristen N.; Neve, Rachael L.; Patel, Tarun B.; Ongur, Dost; Cohen, Bruce M.; Carlezon, William A. (Public Library of Science, 2015)
      Both the development and relief of stress-related psychiatric conditions such as major depression (MD) and post-traumatic stress disorder (PTSD) have been linked to neuroplastic changes in the brain. One such change involves ...